healthgevity

Prime Strength is a powerful, all-in-one formula expertly crafted to amplify muscle growth, accelerate recovery, and support healthy aging—fueling your body for peak performance. This cutting-edge blend features Dileucine and PeptiStrong® peptides, renowned for boosting muscle protein synthesis, minimizing breakdown, and supporting exercise-induced inflammation while lowering myostatin to unlock greater muscle potential,  energy and recovery.   Prime Strength delivers a superior anabolic signal to help you rebuild faster and stronger. It also includes creatine to supercharge strength and endurance, glutamine for optimal recovery and gut health, and taurine to support hydration and peak muscle function. Whether you're aiming to increase strength, improve stamina, or speed up post-workout recovery, Prime Strength delivers the essential nutrients your body needs to reach its full potential and maintain peak health. Crafted with pure, premium ingredients and free from fillers, flavors, and sweeteners, Prime Strength offers maximum versatility—effortlessly mixing into your favorite beverage without compromising taste or quality. Dileucine (DL185™) Dileucine is a next-generation dipeptide made from two bonded leucine molecules—supercharging the well-known anabolic power of leucine by enhancing its delivery and biological impact. While leucine alone is a potent trigger of the mTOR pathway that drives muscle protein synthesis, dileucine is absorbed through a more efficient route: the PEPT1 peptide transporter system, bypassing the limitations of standard amino acid absorption. This allows for faster, more efficient uptake and a quicker anabolic response, especially post-exercise when timing is critical. Research shows that dileucine may activate mTOR even more effectively than leucine, translating to greater muscle growth, improved recovery, and enhanced lean mass retention, particularly during high-stress conditions like intense training, calorie restriction, or fasting. Unlike whole proteins, achieving clinically relevant doses of dileucine from diet alone is nearly impossible, making DL185™ a practical and potent tool for anyone looking to preserve and build muscle. Its versatility makes it ideal for intra-workout, post-workout, between meals, or even pre-sleep in demanding phases like contest prep or aggressive fat loss. With its superior absorption and more powerful anabolic signaling, dileucine is not just an enhancement of leucine—it's a leap forward in muscle optimization. PeptiStrong® (Peptides from hydrolyzed fava bean protein)  Through cutting edge Al-precision technology, Nuritas is creating a brand-new category of precision peptide ingredients from nature. Their cell-signaling power helps the body function at its best. Prime Strength is the third product resulting from Healthgevity's collaboration with Nuritas and contains PeptiStrong®: precision peptides that have been clinically proven to support muscle health. PeptiStrong® can increase muscle synthesis by supporting mTOR, reduce muscle loss by downregulating muscle atrophy related genes and improve muscle health by reducing inflammation properties. Backed by two peer-reviewed clinical studies, this plant-based intelligent ingredient has outperformed animal protein. It has a multi-dimensional effect on muscle health: promoting muscle strength, improving recovery after intense exercise, boosting energy,and supporting the synthesis of protein that assists in maintaining and building muscle. A 'peptide-specific’ effect to address the muscle homeostasis between muscle protein synthesis, muscle atrophy and inflammation, offers an alternative to a purely uncharacterized nutritional intervention.  In the most recent double blind placebo clinical study, PeptiStrong®  alone provided:   Featured PeptiStrong® research benefits:  Regenerates muscles by increasing the expression of new muscle fibers. Type I “Slow Twitch” Muscle Fibers are responsible for endurance and strength endurance. They contain a higher number of mitochondria and utilize fat for energy. Type II “Fast Twitch” Muscle fibers are responsible for strength and forceproduction. Loss of Type II fibers is most associated with aging. Reduces muscle loss and fat accumulation Reduces Tumor Necrosis Factor-alpha (TNF-α) Improves cellular metabolism through the activation of AMPK which in turn increases the levels of NAD+ and sirtuins Maintains autophagy in skeletal muscle similar to fasting Induces mitochondrial biogenesis in the muscle cell Creatine Creatine is a naturally occurring amino acid predominantly stored in muscle tissue and the brain. Synthesized endogenously from other amino acids, creatine is also found in dietary sources such as meat, eggs, and fish. It plays a crucial role in cellular energy production by contributing to the formation of adenosine triphosphate (ATP), the energy currency essential for high-intensity physical activity, cardiac function, and cognitive processes. It works by replenishing ATP (adenosine triphosphate), the primary energy source for muscle contractions during high-intensity exercise. By enhancing ATP production, creatine increases strength, endurance, and overall muscle performance, helping you push through workouts with greater intensity and recover faster. GlutamineGlutamine is an important amino acid that promotes optimal recovery and supports gut health. During intense physical activity, glutamine levels can become depleted, leading to slower recovery times. Supplementing with glutamine helps replenish these levels, speeding up recovery and reducing muscle fatigue. Additionally, glutamine plays a vital role in maintaining a healthy gut lining, supporting digestion, and improving overall nutrient absorption. TaurineTaurine is a versatile amino acid that plays a key role in hydration and muscle function. It helps regulate electrolyte balance, supporting proper muscle contraction and preventing cramping. By promoting fluid balance, taurine ensures that muscles stay hydrated, which is essential for endurance and overall stamina. It also contributes to cardiovascular health and helps reduce oxidative stress, further supporting performance during physical exertion. *This item may take longer to ship out*

Prime Time+ is a cutting-edge formula designed to support healthy aging by optimizing the body’s natural renewal processes. Powered by an industry-leading 10mg's of spermidine per serving, Prime Time+ helps activate autophagy, the body’s mechanism for clearing out old, damaged cells, while promoting the rejuvenation of stem cells. By mimicking the effects of fasting, this comprehensive blend encourages cellular regeneration and the efficient removal of aged cells, enhancing overall healthspan. In addition to its role in autophagy, Prime Time+ supports stem cell release and migration, crucial for tissue repair and cellular renewal. These stem cells play a vital role in maintaining organ and tissue health, promoting recovery, and enhancing vitality. Backed by emerging research, Prime Time+ is an essential part of any longevity protocol, empowering you to optimize vitality, cellular health, and the body’s natural healing processes. Prime Time+ was formulated to support:   Stem cell release and migration* Boosting autophagy and promote cellular renewal*  Fasting* Helps to preserve, protect, and regenerate the endothelial glycocalyx* The body’s innate repair system* Strengthens and enhance the body’s natural immune response* Epigenetic aging support*  Modulates natural inflammatory responses* Skin and eye health* SpermidineSpermidine, a natural polyamine, plays a critical role in molecular and cellular interactions involved in various physiological and functional processes. Spermidine has been shown to modulate aging, suppress the occurrence and severity of age-related diseases, and prolong lifespan.  The concentration of spermidine declines with age, and exogenous spermidine supplementation reverses age- associated adverse changes and supports health span. Given that it interacts with various molecules, spermidine influences aging through diverse mechanisms.  Autophagy is the body's way of cleaning out damaged cells, to regenerate newer, healthier cells and is the main mechanism of spermidine. In addition, spermidine exerts its effects through other mechanisms, including anti-inflammation, histone acetylation reduction, lipid metabolism and regulation of cell growth and signaling pathways. CyanthOx™ Sea Buckthorn Extract CyanthOx™ is a potent extract derived from the ancient Sea Buckthorn plant, native to the Tibetan Plateau, which has evolved over a billion years to develop a unique blend of polyphenols, proanthocyanidins, and flavonoids. This powerful combination of antioxidants gives CyanthOx™ exceptional free radical-scavenging properties, contributing to a wide array of health benefits. Recent clinical research published in Clinical Interventions in Aging highlights its ability to stimulate three distinct types of stem cells, supporting anti-aging, reducing inflammation, and promoting skin vitality, vascular health, and improved blood circulation. CyanthOx™ harnesses the power of nature’s evolutionary defense mechanisms to deliver unparalleled support for overall health and longevity. StemEnhance® (Aphanizomenon flos-aquae concentrate(AFA) Aphanizomenon flos-aquae (AFA) concentrate is a rare, nutrient-rich blue-green algae harvested from the pristine waters of Upper Klamath Lake in Oregon, enhanced with a concentrated dose of AFA polysaccharides. What sets AFA apart is its exceptional nutrient profile, providing bioavailable essential amino acids, vitamins, minerals, and powerful antioxidants. Notably, it boasts a high concentration of phycocyanin, a potent antioxidant with strong anti-inflammatory and immune-enhancing effects. Phycocyanin is also known for stimulating the production and release of adult stem cells, which play a key role in cellular repair and regeneration. Additionally, AFA contains phenylethylamine (PEA), often referred to as the "molecule of love," which helps elevate mood, enhance mental clarity, and improve cognitive function. This unique blend of nutrients positions AFA as a true brain and body health booster, supporting energy levels, immune function, cellular renewal, and overall vitality. AFA’s primary mechanism of action involves inhibiting the production of the inflammatory eicosanoid leukotriene B4, further promoting a balanced immune response. StemEnhance® supports the increase of immune function by stimulating the release of stem cells from the bone marrow.  CyaninPlus® Blue Spirulina Extract (Phycocyanin >30%) CyaninPlus® Blue Spirulina Extract, standardized to contain more than 30% phycocyanin, offers a powerful array of health benefits thanks to its rich antioxidant and anti-inflammatory properties. Phycocyanin, the active compound in Blue Spirulina, helps neutralize harmful free radicals, protecting cells from oxidative stress and reducing inflammation throughout the body mainly due to it being one of the strongest natural COX-2 inhibitors. This potent extract supports a healthy immune system, promotes detoxification, and has been shown to enhance liver function and overall energy levels. Additionally, CyaninPlus® is a nutrient-dense source of essential amino acids, vitamins, and minerals, contributing to improved vitality, cellular health, and longevity.  Fucoidan from Mekabu (Undaria pinnatifida) (sporophyll) Mekabu Extract, derived from the sporophyll of Undaria pinnatifida (a type of brown seaweed), is rich in fucoidan, a bioactive compound with extensive health benefits. Standardized to contain 85% fucoidan, Mekabu Extract is renowned for its immune-boosting, anti-inflammatory, and antioxidant properties. Fucoidan has been shown to support healthy cell regeneration, promote immune function, and enhance the body’s natural ability to fend off pathogens. Additionally, it aids in protecting against oxidative stress, helping to maintain cellular integrity and overall vitality. Research also suggests that fucoidan can be a autophagy regulator and is a known stem cell mobilizer.  Astaxanthin (Haematococcus pluvialis microalgae extract) (as AstaReal®) AstaReal® Astaxanthin is the most studied brand of astaxanthin in the world for applications such as skin health, anti-aging, muscle endurance and recovery, and eye health. Astaxanthin is a powerful carotenoid and antioxidant that plays a crucial role in promoting autophagy, supporting stem cell health, and enhancing healthspan. As a potent antioxidant, astaxanthin helps protect cells from oxidative stress, which can hinder cellular function and accelerate aging. By reducing oxidative damage, astaxanthin encourages the body’s natural autophagy processes, allowing for the removal of damaged proteins and organelles, and promoting the regeneration of healthier cells. This is particularly important for maintaining the vitality of stem cells, which are essential for tissue repair and regeneration. Furthermore, astaxanthin has been shown to modulate key signaling pathways involved in cellular health, enhancing mitochondrial function and promoting metabolic efficiency. By fostering a healthy environment for stem cells and enhancing autophagy, astaxanthin contributes significantly to improved overall health, longevity, and resilience against age-related diseases. Pure Mune™ organic yeast beta 1,3 /1,6 glucan PureMune™ organic yeast beta 1,3/1,6 glucan is a vital nutritional supplement known for its powerful immune-modulating properties which helps facilitate autophagy. Derived from the cell walls of yeast, this natural polysaccharide acts as a potent immune enhancer, stimulating the body’s immune system to respond more effectively to pathogens. Beta glucans have been shown to activate key immune cells, such as macrophages and natural killer (NK) cells, enhancing their ability to recognize and eliminate harmful invaders. Additionally, PureMune™ supports overall immune health by promoting a balanced inflammatory response and reducing the risk of infections. Green Tea providing Epigallocatechin-3-gallate (EGCG) Epigallocatechin-3-gallate (EGCG), the most potent catechin in green tea, has emerged as a key compound in the realm of anti-aging and cellular rejuvenation. Its broad range of health benefits is particularly relevant for supporting stem cells and promoting autophagy—two fundamental processes linked to longevity and vitality. One of EGCG’s primary mechanisms involves its robust antioxidant activity. By neutralizing reactive oxygen species (ROS) and reactive nitrogen species (RNS), EGCG helps reduce oxidative stress, a major driver of cellular damage and senescence. This action protects cells from premature aging and promotes their ability to regenerate, making EGCG a valuable ally in maintaining stem cell health and function. Additionally, EGCG has been shown to stimulate autophagy, the body’s natural process of removing damaged cells and recycling cellular components Alpha-ketoglutarate (AKG) Alpha-ketoglutarate (AKG) is a vital molecule that plays a key role in numerous metabolic and cellular functions, but its levels naturally decline as we age. AKG serves as a critical energy donor, supports the production of amino acids, and functions as a powerful cellular signaling molecule. Additionally, it regulates epigenetic processes that influence gene expression, making it essential for maintaining cellular health and metabolic balance. As a multifaceted compound, AKG helps optimize energy production, cellular regeneration, and overall metabolic function, making it an important nutrient for healthy aging and longevity. Apigenin Apigenin is a powerful natural bioactive plant polyphenol known for its antioxidant, anti-inflammatory, and immune-boosting properties. It plays a crucial role in protecting cells from oxidative stress, which helps improve overall cellular function and resilience. By neutralizing harmful free radicals and reducing inflammation, apigenin supports healthier aging, enhances the body’s defense mechanisms, and promotes optimal cellular performance, contributing to long-term well-being and vitality. Studies have shown that apigenin prevents excessive loss of NAD+ by reducing the amount of circulating CD38, allowing NAD+ stores to remain at higher, more youthful levels. Luteolin Luteolin is a naturally occurring flavonoid found in a variety of plants, known for its significant health-promoting properties. As a potent antioxidant, luteolin helps to combat oxidative stress, which plays a key role in cellular aging and disease development. By neutralizing free radicals, luteolin supports overall cellular health and contributes to the protection of tissues and organs, making it a valuable compound for promoting long-term wellness and resilience. AstraGin® (Astragalus membranaceus and Panax notoginseng) root extracts containing astragaloside I, II, IV and ginsenoside Rb1 AstraGin®, a proprietary blend of root extracts from Astragalus membranaceus and Panax notoginseng, plays a significant role in supporting stem cell health and enhancing autophagy. The key bioactive compounds, astragaloside I, IV, and ginsenoside Rb1, are known to promote cellular regeneration and repair by increasing the activity of stem cells. Astragalosides, particularly astragaloside IV, have been shown to stimulate the proliferation of stem cells, aiding in tissue regeneration and supporting the body's natural healing processes. Ginsenoside Rb1, on the other hand, helps enhance autophagy, the process by which cells remove damaged components and recycle them for cellular maintenance. Together, these compounds work synergistically to boost stem cell activity, improve cellular health, and support the body's natural autophagy mechanisms, which are crucial for longevity and healthy aging. Ioniplex® (Fulvic Ionic Mineral Complex) Ioniplex® is a natural fulvic ionic mineral complex designed to enhance nutrient absorption and cellular energy production. By facilitating the transport of essential nutrients into cells while aiding in the removal of waste, it supports the body’s natural detoxification processes. Clinically tested, Ioniplex® has been shown to improve mitochondrial function, optimize glucose metabolism, and promote effective detoxification, making it a powerful component for overall health and vitality. *This item may take longer to ship out*

This exclusive formula is designed to support the balance and absorption of fat-soluble vitamins in the body. Help protect your bones, heart, immune health and much more with Protect+.* This unique, high-potency formula features:  300mcg of a double micro-encapsulated bioactive all-trans K2VITAL Delta MK-7   250 mcg (10,000 IU) of vitamin D3  Efficacious amounts of vitamin A and vitamin E   AstraGin (astragalus membranaceus and panax notoginseng) to promote maximum absorption and delivery of fat soluble vitamins in the body   Vitamin K2 (MK-7) Vitamin K2 is an essential nutrient that plays a vital role in many biological processes. Western diets are limited in vitamin K2, so vitamin K2 must be obtained through supplementation as well. K2 activates proteins involved in calcium metabolism, including osteocalcin, controlling the transport and distribution of calcium from arteries and soft tissues into bones. Among all of the K vitamins, vitamin K2 MK-7 exhibits the best bioavailability and longest half-life, with a half-life of 72 hours compared to two hours observed with K1. Due to its quick uptake and long half-life, K2 MK-7 reaches bones and vessel walls more easily, resulting in more effective activation of proteins, like osteocalcin.  Osteocalcin proteins in the body must be activated to distribute calcium to our bones. These proteins are unlocked and activated by all-trans K2 MK-7. Protect+ contains >99% of the double micro-encapsulated bioactive form of vitamin K2 MK-7, identical to the all-trans K2 MK-7 found in nature and is fully bio-active providing the full benefits of vitamin K2 MK-7. Some supplements containing cis MK-7 are still available on the market, despite it being considered biologically inactive and therefore potentially ineffective. Due to the shape of the molecule, cis MK-7 cannot bind to the sites of enzymes, meaning the vitamin K-dependent proteins remain inactivated. On the other hand, all-trans MK-7 is bioactive, therefore it is important for supplements to include the highest possible percentage of this form of vitamin to achieve the desired health benefits.  Areas of clinical interest and potential roles for MK-7: Most of the new published research has been with higher dosing featured in Protect+ and has been demonstrating effects on new pathways, proteins, and cells. This includes ATP function in mitochondria, antioxidant effects, cardiovascular function, brain health, gut health, and more.   Vitamin D Recent research suggests that vitamin D supplementation may help promote cellular health and healthy aging. Vitamin D3 works by increasing the amount of calcium absorbed from the small intestine, helping to form and maintain bones. Vitamin D benefits the body by playing a role in immunity and controlling cell growth. Vitamin D has been shown to support biochemical processes linked to aging, including a healthy inflammatory response,  autophagy, cell signaling, anti oxidative status and telomere integrity.  There is growing evidence of the role Vitamin D may have in protecting against osteoporosis, high blood pressure, immunity, and many other health conditions.  Vitamin A Vitamin A is a nutrient that is essential for many different functions in the human body. Vitamin A, also known as retinol, plays an important role in bone growth, tooth development, reproduction, cell division, gene expression, and regulation of the immune system. Vitamin A is also necessary for the maintenance of healthy skin, eyes, and mucous membranes. Vitamin A deficiency can lead to a number of serious health problems, including blindness, poor wound healing, and increased susceptibility to infections. Vitamin A is also an important antioxidant that may play a role in prevention and healthy aging.  Vitamin E Vitamin E is an important nutrient that offers a range of benefits for the body. Vitamin E acts as an antioxidant, which means it helps to protect other nutrients from damage. For example, vitamin E helps to protect vitamins A and C, as well as essential fatty acids, from destruction. Vitamin E also helps to protect red blood cells from damage. This is important because red blood cells are responsible for carrying oxygen around the body. AstraGin® AstraGin® is a natural compound derived from the roots of two traditional Chinese herbs: Panax notoginseng and Astragalus membranaceous which contain astragaloside I, II, IV and ginsenoside Rb1. AstraGin® has shown in over a dozen in-vitro studies to improve the absorption of vitamins, amino acids, peptides, folate, glucosamine and other nutrients in Caco-2 cell, the gold standard used by drug companies to study the absorption of new drugs. References: Vitamin K2 MK-7: Lal N, Berenjian A. Cis and trans isomers of the vitamin menaquinone-7: which one is biologically significant? Appl Microbiol Biotechnol. 2020 Apr;104(7):2765-2776. doi: 10.1007/s00253-020-10409-1. Epub 2020 Feb 3. PMID: 32009201. Sato T, Inaba N, Yamashita T. MK-7 and Its Effects on Bone Quality and Strength. Nutrients. 2020 Mar 31;12(4):965. doi: 10.3390/nu12040965. PMID: 32244313; PMCID: PMC7230802. Knapen MH, Braam LA, Drummen NE, Bekers O, Hoeks AP, Vermeer C. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial. Thromb Haemost. 2015 May;113(5):1135-44. doi: 10.1160/TH14-08-0675. Epub 2015 Feb 19. PMID: 25694037. Simes DC, Viegas CSB, Araújo N, Marreiros C. Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies. Int J Mol Sci. 2019 Aug 25;20(17):4150. doi: 10.3390/ijms20174150. PMID: 31450694; PMCID: PMC6747195. Pisoschi AM, Pop A, Iordache F, Stanca L, Geicu OI, Bilteanu L, Serban AI. Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy. Eur J Med Chem. 2022 Mar 15;232:114175. doi: 10.1016/j.ejmech.2022.114175. Epub 2022 Feb 4. PMID: 35151223; PMCID: PMC8813210. Vitamin D:  Chang SW, Lee HC. Vitamin D and health - The missing vitamin in humans. Pediatr Neonatol. 2019 Jun;60(3):237-244. doi: 10.1016/j.pedneo.2019.04.007. Epub 2019 Apr 17. PMID: 31101452. Martens PJ, Gysemans C, Verstuyf A, Mathieu AC. Vitamin D's Effect on Immune Function. Nutrients. 2020 Apr 28;12(5):1248. doi: 10.3390/nu12051248. PMID: 32353972; PMCID: PMC7281985. Ao T, Kikuta J, Ishii M. The Effects of Vitamin D on Immune System and Inflammatory Diseases. Biomolecules. 2021 Nov 3;11(11):1624. doi: 10.3390/biom11111624. PMID: 34827621; PMCID: PMC8615708. Abiri B, Vafa M. Vitamin D and Muscle Sarcopenia in Aging. Methods Mol Biol. 2020;2138:29-47. doi: 10.1007/978-1-0716-0471-7_2. PMID: 32219739. Vitamin A: Bar-El Dadon S, Reifen R. Vitamin A and the epigenome. Crit Rev Food Sci Nutr. 2017 Jul 24;57(11):2404-2411. doi: 10.1080/10408398.2015.1060940. PMID: 26565606. Conaway HH, Henning P, Lerner UH. Vitamin a metabolism, action, and role in skeletal homeostasis. Endocr Rev. 2013 Dec;34(6):766-97. doi: 10.1210/er.2012-1071. Epub 2013 May 29. PMID: 23720297. Stephensen CB, Lietz G. Vitamin A in resistance to and recovery from infection: relevance to SARS-CoV2. Br J Nutr. 2021 Dec 14;126(11):1663-1672. doi: 10.1017/S0007114521000246. Epub 2021 Jan 20. PMID: 33468263; PMCID: PMC7884725. Cantorna MT, Snyder L, Arora J. Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis. Crit Rev Biochem Mol Biol. 2019 Apr;54(2):184-192. doi: 10.1080/10409238.2019.1611734. Epub 2019 May 14. PMID: 31084433; PMCID: PMC6629036. Vitamin E:  Pekmezci D. Vitamin E and immunity. Vitam Horm. 2011;86:179-215. doi: 10.1016/B978-0-12-386960-9.00008-3. PMID: 21419272. Casati M, Boccardi V, Ferri E, Bertagnoli L, Bastiani P, Ciccone S, Mansi M, Scamosci M, Rossi PD, Mecocci P, Arosio B. Vitamin E and Alzheimer's disease: the mediating role of cellular aging. Aging Clin Exp Res. 2020 Mar;32(3):459-464. doi: 10.1007/s40520-019-01209-3. Epub 2019 May 3. PMID: 31054115. Corina A, Rangel-Zúñiga OA, Jiménez-Lucena R, Alcalá-Díaz JF, Quintana-Navarro G, Yubero-Serrano EM, López-Moreno J, Delgado-Lista J, Tinahones F, Ordovás JM, López-Miranda J, Pérez-Martínez P. Low Intake of Vitamin E Accelerates Cellular Aging in Patients With Established Cardiovascular Disease: The CORDIOPREV Study. J Gerontol A Biol Sci Med Sci. 2019 May 16;74(6):770-777. doi: 10.1093/gerona/gly195. PMID: 30165472. Moriguchi S, Muraga M. Vitamin E and immunity. Vitam Horm. 2000;59:305-36. doi: 10.1016/s0083-6729(00)59011-6. PMID: 10714244. AstraGin®: Chang, Tsu-Chung et al. “Effect of ginsenosides on glucose uptake in human Caco-2 cells is mediated through altered Na+/glucose cotransporter 1 expression.” Journal of agricultural and food chemistry vol. 55,5 (2007): 1993-8. doi:10.1021/jf062714k During A, Harrison EH. Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells. J Lipid Res. 2007 Oct;48(10):2283-94. doi: 10.1194/jlr.M700263-JLR200. Epub 2007 Jul 20. PMID: 17644776. Reboul E, Goncalves A, Comera C, Bott R, Nowicki M, Landrier JF, Jourdheuil-Rahmani D, Dufour C, Collet X, Borel P. Vitamin D intestinal absorption is not a simple passive diffusion: evidence for involvement of cholesterol transporters. Mol Nutr Food Res. 2011 May;55(5):691-702. doi:  Reboul E. Vitamin E intestinal absorption: Regulation of membrane transport across the enterocyte. IUBMB Life. 2019 Apr;71(4):416-423. doi: 10.1002/iub.1955. Epub 2018 Oct 11. PMID: 30308094. *This item may take longer to ship out*

Cellular senescence is a hallmark of aging, it is a permanent state of cell cycle arrest induced by cellular stresses. This has numerous implications for the body, including its ability to adapt to changes in its environment, as well as its capacity to regenerate itself. This can be beneficial for individuals to understand how cellular senescence works and what the potential benefits are for the body.  Firstly, understanding cellular senescence can help us better understand aging, as this process is a major contributor to the aging process.  Additionally, it can also provide insight into certain diseases and conditions that may be linked to the inability of cells to divide and proliferate properly.  Finally, by targeting cellular senescence, we may be able to find new ways of fighting against aging and diseases associated with it.  Thus, understanding ways to best support cellular senescence can be a powerful tool in our pursuit of longevity and improved health span.  Senolytics, are small molecules that can selectively kill senescence cells and have been developed to support various age-related diseases while also extending healthspan. In recent years, emerging natural compounds have been discovered to be effective senolytic agents that are featured in this breakthrough formula. Clearance of senescent cells can support the reduction of inflammation, decrease macromolecular dysregulation, and enhance function of stem and progenitor cells. Rejuvenate 2.0 presents a unique solution for intervention through two mechanisms:  (1) eliminating senescent cells (senolytics)   (2) inhibiting of senescent- associated secretory phenotype (SASP)  Featured benefits:  Once weekly pulsed high dosing blend of senolytics which have been shown to reduce senescent cells in vivo. Targets aging at the cellular level Induces autophagy to promote intracellular recycling and cellular renewal Reduce full body features of Senescence-Associated Secretory Phenotype (SASP). Protects cells against free radicals and oxidative stress  Targets inflammaging at the cellular level and supports a healthy inflammatory response Supports a healthy immune system  Formula designed to also treat muscle senescence. Exercises muscles longer and harder with a boost in citrate synthase activity. Recovers more effectively with a reduction in inflammation biomarkers. Decreases SA-β-Gal by 63% in muscle tissue. Fisetin: Fisetin is a polyphenol found in many fruits and vegetables, including strawberries, apples, and onions.  It has been studied for its potential benefits related to aging.  Fisetin has shown great promise to inhibit senescence due to its ability to act on numerous biological processes.  Studies have shown that fisetin is the most natural senolytic agent that can protect cells from oxidative damage, protecting them against age related diseases and reduce senescence markers in multiple tissues.   Quercetin Phytosome: Quercetin is one of the most studied dietary flavonoids ubiquitously present in various vegetables. A key feature of quercetin is its strong antioxidant activity which potentially enables it to quench free radicals from forming resonance-stabilized phenoxyl radicals.  However, chemical instability, poor water solubility and low bioavailability of quercetin greatly limit its applications which is why a phytosome technology is the preferred delivery system to overcome these limitations.  This enhanced form of quercetin has been shown to be 20 times better absorbed than other quercetin options.  Spermidine: NEW higher dose of 10mg's per serving Spermidine has emerged as an important metabolite that links cellular aging and autophagy. Spermidine is a naturally occurring polyamine involved in biological processes such as cell growth and proliferation, tissue regeneration and translation regulation, making it a critical regulator of cellular homeostasis. Spermidine also exhibits anti-inflammatory and anti-aging properties. External supplementation of spermidine improves longevity, which may be attributed to its ability to exert cardioprotective and neuroprotective effects, as well as reducing immune senescence.  Senactiv® (Panax notoginseng (root) and Rosa roxburghii (fruit)) extracts containing ginsenoside Rg1: Senactiv® promotes more energy and muscle preservation by activating phagocytic macrophages in association with the senescent cell clearance in muscle tissue after aerobic exercise. It's composed of two highly purified and fractionated extracts from Panax notoginseng and Rosa rugosa.  Research suggests that this combination is a potent senolytic. Muscle samples taken before and after exercise shows that Senactiv® supplementation resulted in significantly fewer amounts of detectable β-galactosidase-tagged cells which is a  method to assess cellular senescence.  In a recent Senactiv® human clinical study confirmed, though exercise generally increases the movement of white blood cells and “clean up” cells into the muscle, it does not always activate phagocytosis to clear away the broken down apoptotic cells and senescent cells . With Senactiv®, phagocytosis activation can clear these types of cells away leading to the decrease in both apoptotic and senescent cells in active muscles. L-Ergothioneine (as MitoPrime®)--NEW ingredient added Ergothioneine is an amino acid — a building block to proteins — that is synthesized by bacteria and fungi, leading mushrooms to be the primary dietary source. Since its discovery, the unique properties of the, ergothioneine has intrigued researchers for more than a century.  Emerging research shows that it is a full spectrum cyto-restorative that protects and repairs the complete cell, including DNA and mitochondria, from the full array of assaults both endogenous and exogenous.  Ergothioneine is an antioxidant concentrated in mitochondria, suggesting a specific role in protecting mitochondrial components such as DNA from oxidative damage. Ergothioneine is readily absorbed after oral supplementation, resulting in significant increases in plasma and whole blood ergothioneine levels.  Recent studies have confirmed its potential as an effective therapeutic strategy for the elimination of senescent cells. In one study using cells exposed to oxidative conditions found that ergothioneine treatment significantly lengthened telomeres and reduced the percentage of shortened telomeres after eight weeks. Treating the cells with ergothioneine also boosted the activity of telomerase which is the only enzyme that maintains telomere length. Another recent publication investigated how ergothioneine levels relate to mortality. The looked at levels of 112 compounds in the blood of 3,200 Swedish adults, ergothioneine exhibited the strongest connection with reduced mortality — higher levels of the compound markedly reduced the risk of all-cause mortality, cardiovascular-related mortality, or developing heart disease at all.  Due to the recent published research, ergothioneine is being referred to as the ‘longevity vitamin’.  TurmiPure GOLD® Turmeric (Curcuma longa L.) has been used in India for more than 5,000 years as a spice and medicinal herb in traditional ayurvedic medicine. Well-known for its anti-inflammatory properties, it is now recognized as the #1 botanical for healthy aging. However, its poor bioavailability (number of actives reaching the blood stream) in curcuminoids lowers its efficacy and its poor solubility limits its application (often limited to capsules and tablets), therefore high intake (~1500mg) of standard turmeric extract was shown to be efficient. After 5 years of research, our partner has overcome these issues by developing TurmiPure GOLD®, the world’s first bioequivalent turmeric at a low dose of 300mg. Its innovative formulation highly enhances the bioavailability of curcuminoids 24X, in addition to being instantly water dispersible. A dose of 300mg of TurmiPure Gold® delivers as many curcuminoids in blood as 1922mg of standard turmeric 95% curcuminoids (with or without addition of 1% black pepper extract standardized to 95% piperine). Curcuminoids are clinically proven to be effective in more than 100 studies to support: healthy joint function (including inflammatory response), normal bile production and overall body function, contributing to healthy aging conditions. Curcumin has shown promise to mitigate the senescence-associated secretory phenotype (SASP) and its aging-induction consequences of senescent cells. Tetrahydrocurcumin (CurcuPrime®)  Tetrahydrocurcumin (4-HC) is the key bioactive derivative of curcumin and with advances in science, it’s also given credibility as the engine behind all that curcumin brings to the table. With a newfound ability to extract and isolate the compound, research has even seen tetrahydrocurcumin outperform its parent compound in several tests of its capabilities. Researchers have also confirmed that 4-HC attenuated pro-inflammatory indicators like interleukin-1, interleukin-6, TNF-⍺, and prostaglandin E2. Apigenin: Apigenin is a natural bioactive plant polyphenol with antioxidant, anti-inflammatory and immune system boosting properties.  It also helps to support against oxidative stress for better cellular function. Studies have shown that apigenin prevents excessive loss of NAD+ by reducing the amount of circulating CD38, allowing NAD+ stores to remain at higher, more youthful levels. Apigenin is known to induce apoptosis in a p53-independent pathway by enhancing oxidative stress. The p53-independent apoptotic effects of apigenin would support its use as a senolytic  Luteolin:Luteolin is a flavonoid naturally found in plants. Flavonoids like luteolin have been found to have beneficial effects on human health by reducing oxidative stress.  Luteolin, which acts as the first-line defense system in plants against adverse photobiological effects such as protection against UV radiation, has shown promising senotherapeutic effects  Green Tea containing epigallocatechin gallate (EGCG)  The phytochemical epigallocatechin gallate (EGCG) is the major catechin found in green tea, with many potential benefits on health outcomes, including cell senescence, aging, and age-related diseases.  Preclinical evidence suggests that EGCG exhibits promising senolytic and senomorphic effects through multi-faceted mechanisms, including targeting apoptotic pathways, cell cycle regulation, nutrient sensing pathways, SASP, and oxi-inflammatory stress pathways. AstraGin® (Astragalus membranaceus and Panax notoginseng) root extracts containing astragaloside I, II, IV and ginsenoside Rb1: AstraGin® is a proprietary plant derived compound complex extracted by a proprietary pharmaceutical extraction and processing technology. AstraGin® upregulates mRNA and protein expression levels of nutrient transporters that regulate the absorption of nutrients and plant compounds in the gut.  AstraGin® has shown in 16 in-vitro and 8 in-vivo studies that are published in the Journal of Agricultural and Food Chemistry, Molecular Nutrition & Food Research and Scientific Reports to:  Increase the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up regulating the absorption specific mRNA and transporters, such as SGLT1, CAT1, and GLUT4.  One example is AstraGin® has been shown to increase curcumin absorption by 92%. Repair ulcerated and damaged intestinal walls and reduce intestinal submucosa inflammation. AstraGin® was shown in a hematoxylin-eosin stain and a MPO assay to reduce ulceration and unclear surfaces of intestinal epithelial cells and sub-mucosal edema in TNBS- induced colitis rats.  May help maintain a healthy microbiota population by mending ulcerated and damaged intestinal epithelial cell surfaces for the microbiota to populate.  May help support stronger immune functions by mending ulcerated epithelial cells and reducing the inflammation in intestinal mucosal lamina propria that hosts the gut- associated lymphoid tissue (GALT1), T cells, plasma cells, mast cells, dendritic cells, and macrophages.  *This item may take longer to ship out*

Aging is characterized by an increase in the concentration of inflammatory markers in the blood- stream, a phenomenon that has been termed “inflammaging”. The inflammatory response is beneficial as an acute, transient reaction to harmful conditions, facilitating the defense, repair, turnover and adaptation of many tissues. However, chronic and low-grade inflammation is likely to be detrimental for many tissues and for normal functions.  Our team investigated various natural solutions targeting multiple influences of inflammaging.  Resolve+ contains numerous compounds that have been found to reduce the inflammatory response by targeting a variety of mechanisms.  Acmella oleracea (“jambu”) is sourced from Sardinia, Italy and rich in alkylamides mainly represented by spilanthol. Its flowers are widely used in folk medicine to treat toothache due to tingling, numbness, and local anesthesia caused in the mouth.  Acmella oleracea has been shown to be active in fatty acid amide hydrolase (FAAH) inhibition the enzyme responsible for the degradation of fatty acid amides and cannabinoid type 2(CB2) activation.  There are almost 100 studies suggesting the supportive potential for anti-inflammatory, antioxidant, and analgesic effects of Acmella. Studies reported in this review confirmed activities of Acmella, postulating that transcription factors of the nuclear factor-κB family (NF-κB) trigger the transcription iNOS and COX-2 and several other pro-inflammatory mediators, such as IL-6, IL-1β, and TNF-α. Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L.), has been well documented to exhibit various health benefits. There have been many claims on the health benefits of curcumin on neurological, cardiovascular, lung, metabolic, and liver function, mainly through its anti-inflammatory and antioxidant properties. Despite its promising potential, the clinical application of curcumin has been limited due to its low bioavailability. To enhance curcumin absorption, we are the first to feature Theracurmin Super® 85X, a proprietary curcumin utilizing the latest technology that transforms standard curcumin into an amorphous structure. Theracurmin Super® 85X uses the latest technology to transform regular curcumin particles into a more bioavailable structure. This is done by splitting curcumin particles’ crystal structure amorphous, therefore, making it easily absorbed and bioavailable to maximize its supportive potential. Tetrahydrocurcumin (4-HC) is the key bioactive derivative of curcumin, it’s also given credibility as the engine behind all that curcumin brings to the table. With a newfound ability to extract and isolate the compound, research has even seen tetrahydrocurcumin outperform its parent compound in several tests of its capabilities. Researchers have also confirmed that 4-HC attenuated pro-inflammatory indicators like interleukin-1, interleukin-6, TNF-⍺, and prostaglandin E2.  After reviewing the data, we found many advantages to infuse tetrahydrocurcumin as CurcuPrime®stacked with Theracurmin Super® 85X into Resolve+. Quercetin is a well-known studied dietary flavonoid ubiquitously present in various vegetables. Quercetin is known for its antioxidant activity in radical scavenging and anti-allergic properties characterized by stimulation of immune system, antiviral activity, inhibition of histamine release, decrease in pro-inflammatory cytokines, leukotrienes creation, and suppresses interleukin IL-4 production.  Multiple studies have confirmed its supportive potential as an immune modulator and its ability to support a healthy inflammatory response. It can improve the Th1/Th2 balance, and restrain antigen specific IgE antibody formation However, chemical instability, poor water solubility and low bioavailability of quercetin greatly limit its applications which is why a phytosome technology which we feature in resolve is the preferred delivery system to overcome these limitations.  This enhanced form of quercetin has been shown to be as much as 20 times better absorbed than other quercetin options.  Casperome®  boswellia phytosome is a potent extract made from the resin of Boswellia serrata trees and is also referred as Indian frankincense. Boswellia extracts have been demonstrated to be effective in the management of various inflammatory response functions including those that occur in the bowel, joints, bones, respiratory airways and in the brain. The mechanism of action that involves the modulation of the natural inflammatory response both acting on prostanoid synthesis (mPGE2S) and protein degradation (caspases), and transcription factors (Nf-κB).  We have selected Casperome® which is a highly standardized in boswellic acids to match the natural composition of boswellia, formulated with phytosome technology to achieve optimized absorption and has been validated by over 10 human studies. Perilla frutescens is an annual herb belonging to the mint family (Lamiaceae). It is mainly produced in countries like China, Japan, India, Thailand and Korea. Recently, Perilla is gaining more attention because of its medicinal benefits and phytochemical contents. The functional compounds of Perilla Seed Extract are flavonoid Aglycons – polyphenols such as Luteolin, Apigenin, Chrysoeriol, and Rosemarinic Acid. Studies have shown that Perilla seed polyphenols regulate allergic and inflammatory response due to its 5-lipoxygenase inhibitory activity and suppression potential of histamine release from mast cells. AstraGin® is a natural compound derived from the roots of two traditional Chinese herbs: Panax notoginseng and Astragalus membranaceous which contain astragaloside I, II, IV and ginsenoside Rb1. AstraGin® has been shown to provide full-spectrum gut support through enhanced absorption, microbiota and immune cell viability, and supporting a health. AstraGin® has been shown in numerous studies to increase the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up regulating the absorption specific mRNA and transporters, such as SGLT1, CAT1, and GLUT4. Additionally, AstraGin® was shown to reduce intestinal inflammatory biomarker MPO, the pro-inflammatory cytokines IL-6, IL-17, and IL-1β in ulcerative colitis patients. *This item may take longer to ship out*

Elevated stress levels can compromise the immune system, leading to increased irritability, loss of interest, and nervousness. It can also disrupt sleep patterns, resulting in racing thoughts that prevent restful sleep. This, in turn, can strain relationships, reduce productivity, and trigger anger issues. Furthermore, stress can contribute to weight gain through unhealthy coping mechanisms like overeating and impair concentration due to a heightened state of vigilance. The long-term implications of chronic stress are significant, impacting both physical and mental health. Reducing stress levels is essential for promoting overall well-being, supporting healthy living, and encouraging healthy aging. Serenity was created to support our bodies response to stressful situations and is fast-acting so it can be depended on whenever you need it most.  Serenity features a combination of the latest clinically validated ingredients that are exclusively combined at therapeutic doses. Serenity from Healthgevity is a top natural option for enhancing stress resilience and supporting overall mental and physical well-being.  *This item may take longer to ship out* Featured Benefits: Supports a healthy stress response Promotes an overall sense of calmness Helps support relaxation and reduction of nervousness Helps maintain healthy cortisol levels during everyday stress Maintains healthy neurotransmitter release (Specifically, GABA) Promotes both healthy REM & Non-REM sleep cycles DHH-B (Dihydrohonokiol-B) from Magnolia Bark Magnolia bark plays a central role in traditional Chinese medical formulas as a natural anxiolytic. Honokiol extracted from the bark has been studied independently to investigate its mechanisms of action on the central nervous system and has been shown to interact with neurotransmitter gamma-aminobutyric acid (GABA) receptors.  A natural variant of honokiol exists with a much better profile, selectivity, and strength of the Honokiol. It is called DHH-B (or dihydrohonokiol-B) and is 20x the strength as the natural Magnolia Bark (Honokiol). DHH-B is a promising compound known for its therapeutic properties, particularly in stress relief, relaxation, and supporting healthy sleep patterns. DHH-B enhances the activity of gamma-aminobutyric acid (GABA), a key inhibitory neurotransmitter that helps reduce neuronal excitability. By increasing GABA activity, DHH-B can improve sleep quality and decrease anxiety levels. Additionally, DHH-B interacts with the body's endocannabinoid system by activating cannabinoid receptors. This interaction can enhance mood, alleviate pain, and reduce inflammation, providing a comprehensive approach to emotional and physical well-being.   DHH-B has also been shown to lower adrenaline levels, helping to mitigate the physiological effects of chronic and severe stress. The compound's antioxidant properties further contribute to its neuroprotective and anti-aging effects. DHH-B effectively scavenges reactive oxygen species and enhances the body's endogenous antioxidant defenses, thereby supporting neurological health and protecting against oxidative stress. It also modulates the immune response by influencing the production of pro-inflammatory cytokines. Holixer™ Holy Basil Extract Holy Basil (Ocimum tenuiflorum), also known as Tulsi, has a long history of use in traditional Indian and Asian medical systems. Unlike common culinary basil, Holy Basil is highly revered for its medicinal properties and has been used for centuries in Ayurveda and other traditional practices. Recent research has corroborated the herb's traditional uses, highlighting its potential to support a healthy stress response, enhance sleep quality, and offer anxiolytic and adaptogenic benefits. Serenity features a specialized form of Holy Basil called Holixer™ which is a patented and extensively researched preparation standardized to contain at least 5% Ocimum Bioactive Complex, a unique blend of bioactive compounds including Rabdosin, Rosmarinic acid, Luteolin-7-o-beta-glucuronide, Ociglycoside I, and Apigenin-7-o-beta-glucuronide. These bioactive components are thought to contribute to Holy Basil's therapeutic effects. For instance, Rosmarinic acid and Apigenin-7-o-beta-glucuronide have been shown to possess anti-inflammatory and antioxidant properties, which may help mitigate the physiological impact of stress. Luteolin-7-o-beta-glucuronide and Ociglycoside I are known for their potential neuroprotective effects, which could play a role in improving cognitive function and mood stability under stress. Rabdosin, another key component, may aid in balancing the body's stress hormones, thus supporting a more resilient stress response. In clinical studies, Holixer™ Holy Basil has been observed to promote better sleep by modulating the stress response and reducing the activity of the hypothalamic-pituitary-adrenal (HPA) axis. This, in turn, helps to lower cortisol levels, which are often elevated in individuals experiencing chronic stress. Lower cortisol levels are associated with improved sleep quality and reduced feelings of anxiety. Natural GABA probiotic L. plantarum 815 (LP815™) GABA is a major inhibitory neurotransmitter in the central nervous system, playing a crucial role in modulating neuronal excitability and maintaining balance in brain signaling. GABA's primary mechanism of action involves reducing the excitability of neurons, thereby aiding in mood stabilization, stress regulation, and sleep quality. Insufficient GABA levels can result in various health issues, including heightened stress, mood disturbances, poor sleep quality, and impaired cognitive function. GABA Probiotic  is formulated to provide a sustained release of GABA, offering continuous calming and stress support throughout the day and night. Unlike traditional GABA supplements, which often lead to a rapid but short-lived increase in GABA levels, GABA Probiotic ensures a more stable and prolonged delivery of this neurotransmitter. This is achieved through the use of a proprietary strain of Lactiplantibacillus plantarum, Lp815™, which has been specifically selected for its ability to produce GABA over an extended period. The choice of Lp815™ is backed by advanced computational modeling and high-throughput screening, allowing for the identification of a strain that outperforms other industry-leading strains in sustained GABA production. The strain's unique capability lies in its robust GABA synthesis in the gastrointestinal tract, leveraging the gut-brain axis—a bidirectional communication pathway between the gut microbiota and the brain. By producing GABA locally in the gut, Lp815™ may influence central nervous system function and mood regulation, providing a dual pathway for enhancing GABA levels. This sustained production is particularly beneficial compared to traditional GABA supplements, which often require multiple doses throughout the day due to their transient effects. The prolonged release profile of GABA Probiotic reduces the need for frequent redosing, thereby offering a more convenient and consistent option for patients seeking to manage stress and support mood stability. Saffron Extract (as affron®) We also included affron® Saffron Extract, which is a highly acclaimed and extensively researched form of saffron, recognized for its rapid and comprehensive effects on both brain and body health. This premium extract has been shown to work within approximately one hour, delivering significant benefits such as reduced oxidative stress, balanced neurotransmitter levels, enhanced neuroplasticity, and improvements in memory and sexual function. Clinical evidence supports affron® as the most studied saffron extract with eight human clinical studies, demonstrating its ability to improve mood in healthy adults experiencing occasional stress and anxiety.  In a randomized, double-blind, placebo-controlled study, participants who consumed 28 mg/day of affron® for four weeks experienced a 41% improvement in mood, along with a significant reduction in occasional stress, frustration, and tension compared to the placebo group L-Theanine (as L-TeaActive®) Theanine is an amino acid that is not commonly found in the human diet, as it is not one of the essential or nonessential amino acids. L-theanine is often called a “nondietary amino acid.” Because of its structure, theanine is known to reach the brain quickly following oral consumption. L-theanine is present in various food sources but is found mainly in both green and black teas.  Theanine is found to be relaxing, but not sedating agent, and has been found to help process stress and to improve attention. It has also been found to aid in sleep quality. L-Theanine: A Natural Supplement for Anxiety? Studies show that increasing intake of theanine can significantly reduce symptoms of anxiety, such as a racing heartbeat and increased secretion of immunoglobulin A in saliva. Its effects are somewhat similar to those of a sedative, but L-theanine is far from this prescription drug. It is actually considered to be an effective anxiolytic, which helps to prevent the brain from producing an anxious response to stressful situations. How Does L-Theanine for Anxiety Work? L-theanine is processed in the brain through the blood-brain barrier. The blood-brain barrier is similar to a gateway that prevents blood borne substances from crossing over into the brain; it is a form of protection for one of the body’s most important organs. While this barrier is beneficial, it does have its downsides; most notably, it prevents many medications from reaching their target area. Research shows that 98% of small molecule neurotherapies, and 100 percent of large molecule neurotherapies can’t pass through the blood-brain barrier, rendering many types of common treatments for anxiety almost useless.   L-theanine is different. It uses the leucine-preferring transport system to hitch a ride across the blood-brain barrier, allowing it to target the brain directly. Essentially, theanine is better able to get to where it needs to be efficiently.  Once past the blood-brain barrier, L-theanine enacts a variety of neurophysiological and pharmacological effects. It has been found to up-regulate inhibitory neurotransmitters, and blocks the binding of L-glutamic acid to glutamate receptors in the brain. It has also been found to potentially modulate serotonin and dopamine in select areas of the brain. L-theanine’s inhibition of cortical neuron excitation can have anti-stress effects. The three main mechanisms of how L-theanine works in the brain: Dampens the effects of excitatory brain chemicals ○     L-theanine is reported to target a number of glutamate receptors, including N-methyl-D-aspartate (NMDA), α-amino-3-hydroxy-5-methyl- 4-isoxazolepropionic acid (AMPA) and kainite receptors, although at a much lower affinity compared to glutamate Increases levels of calming and mood-elevating brain chemicals ○     L-theanine also stimulates the production of the calming brain chemicals like γ-aminobutyric acid (GABA), serotonin and dopamine adding to its calming and relaxing effects without sleepiness or impaired motor function Increases alpha brain waves ○     This increase in alpha wave activity is thought to contribute to L-theanine’s relaxing yet alert effects.

Featured Benefits: Promotes deeper, more restorative sleep by enhancing both REM and non-REM cycles* Extends duration of deep and REM sleep to support overnight recovery and regeneration* Improves overall sleep quality—without sedation or next-day grogginess* Supports waking up refreshed, focused, and mentally clear* Calms the mind and body before bed by supporting a healthy stress response* Helps ease nervousness and mental overactivity that can delay sleep onset* Maintains healthy evening cortisol levels for a smoother transition to sleep* Supports balanced neurotransmitter function, including GABA, to quiet the nervous system* Melatonin-free  PEPTISLEEP™ SLEEPgevity™ is the first formula globally to feature PeptiSleep™—a next-generation bioactive peptide developed in collaboration with Nuritas, using advanced AI-driven peptide discovery. Specifically designed to support healthy, restorative sleep, PeptiSleep™ offers a novel, non-sedating approach that works in harmony with the body’s natural circadian rhythm Its mechanism of action targets two key pathways involved in sleep regulation: Cortisol modulation to reduce stress-related hyperarousal Orexin (hypocretin) pathway downregulation, calming the central nervous system and supporting sleep onset By addressing both stress and wakefulness signaling, PeptiSleep™ facilitates a smooth, anxiety-free transition into sleep, enhances sleep architecture, and helps patients stay asleep longer without disruption. In clinical use, patients reported: Faster sleep onset Improved Deep and REM sleep Increased Heart Rate Variability (HRV)—a marker of parasympathetic nervous system activation Waking up feeling clear, focused, and refreshed SLEEPgevity™ offers healthcare providers a non-sedating, physiologically aligned approach to sleep support—ideal for those seeking effective results without the drawbacks of traditional pharmacologic sleep aids TRYPTOPHAN Tryptophan was strategically included in the SLEEPgevity™ formula to enhance its ability to support the natural production of serotonin and melatonin, two key neurotransmitters essential for mood regulation and healthy sleep cycles. As an essential amino acid, tryptophan serves as the precursor to 5-HTP (5-hydroxytryptophan) and subsequently serotonin, which not only influences emotional well-being but also plays a critical role in initiating and maintaining sleep. Serotonin is then converted into melatonin, the body’s primary sleep hormone that governs circadian rhythms and sleep-wake timing. By supporting this pathway, tryptophan complements the cortisol-lowering and orexin-modulating effects of PeptiSleep™, helping to: Promote relaxation and emotional calm Support melatonin synthesis for improved sleep onset Enhance the overall depth and quality of sleep DHH-B (DIHYDROHONOKIOL-B) FROM MAGNOLIA BARK Magnolia bark plays a central role in traditional Chinese medical formulas as a natural anxiolytic. Honokiol extracted from the bark has been studied independently to investigate its mechanisms of action on the central nervous system and has been shown to interact with neurotransmitter gamma-aminobutyric acid (GABA) receptors.  A natural variant of honokiol exists with a much better profile, selectivity, and strength of the Honokiol. It is called DHH-B (or dihydrohonokiol-B) and is 20x the strength as the natural Magnolia Bark (Honokiol). DHH-B is a promising compound known for its therapeutic properties, particularly in stress relief, relaxation, and supporting healthy sleep patterns. DHH-B enhances the activity of gamma-aminobutyric acid (GABA), a key inhibitory neurotransmitter that helps reduce neuronal excitability. By increasing GABA activity, DHH-B can improve sleep quality and decrease anxiety levels. Additionally, DHH-B interacts with the body's endocannabinoid system by activating cannabinoid receptors. This interaction can enhance mood, alleviate pain, and reduce inflammation, providing a comprehensive approach to emotional and physical well-being.   DHH-B has also been shown to lower adrenaline levels, helping to mitigate the physiological effects of chronic and severe stress. The compound's antioxidant properties further contribute to its neuroprotective and anti-aging effects. DHH-B effectively scavenges reactive oxygen species and enhances the body's endogenous antioxidant defenses, thereby supporting neurological health and protecting against oxidative stress. It also modulates the immune response by influencing the production of pro-inflammatory cytokines. HOLIXER™ HOLY BASIL EXTRACT  Holy Basil (Ocimum tenuiflorum), also known as Tulsi, has a long history of use in traditional Indian and Asian medical systems. Unlike common culinary basil, Holy Basil is highly revered for its medicinal properties and has been used for centuries in Ayurveda and other traditional practices. Recent research has corroborated the herb's traditional uses, highlighting its potential to support a healthy stress response, enhance sleep quality, and offer anxiolytic and adaptogenic benefits. SLEEPgevity™ features a specialized form of Holy Basil called Holixer™ which is a patented and extensively researched preparation standardized to contain at least 5% Ocimum Bioactive Complex, a unique blend of bioactive compounds including Rabdosin, Rosmarinic acid, Luteolin-7-o-beta-glucuronide, Ociglycoside I, and Apigenin-7-o-beta-glucuronide. These bioactive components are thought to contribute to Holy Basil's therapeutic effects. For instance, Rosmarinic acid and Apigenin-7-o-beta-glucuronide have been shown to possess anti-inflammatory and antioxidant properties, which may help mitigate the physiological impact of stress. Luteolin-7-o-beta-glucuronide and Ociglycoside I are known for their potential neuroprotective effects, which could play a role in improving cognitive function and mood stability under stress. Rabdosin, another key component, may aid in balancing the body's stress hormones, thus supporting a more resilient stress response. In clinical studies, Holixer™ Holy Basil has been observed to promote better sleep by modulating the stress response and reducing the activity of the hypothalamic-pituitary-adrenal (HPA) axis. This, in turn, helps to lower cortisol levels, which are often elevated in individuals experiencing chronic stress. Lower cortisol levels are associated with improved sleep quality and reduced feelings of anxiety. NATURAL GABA PROBIOTIC L. PLANTARUM 815 (LP815™) GABA is a major inhibitory neurotransmitter in the central nervous system, playing a crucial role in modulating neuronal excitability and maintaining balance in brain signaling. GABA's primary mechanism of action involves reducing the excitability of neurons, thereby aiding in mood stabilization, stress regulation, and sleep quality. Insufficient GABA levels can result in various health issues, including heightened stress, mood disturbances, poor sleep quality, and impaired cognitive function. GABA Probiotic  is formulated to provide a sustained release of GABA, offering continuous calming and stress support throughout the day and night. Unlike traditional GABA supplements, which often lead to a rapid but short-lived increase in GABA levels, GABA Probiotic ensures a more stable and prolonged delivery of this neurotransmitter. This is achieved through the use of a proprietary strain of Lactiplantibacillus plantarum, Lp815™, which has been specifically selected for its ability to produce GABA over an extended period. The choice of Lp815™ is backed by advanced computational modeling and high-throughput screening, allowing for the identification of a strain that outperforms other industry-leading strains in sustained GABA production. The strain's unique capability lies in its robust GABA synthesis in the gastrointestinal tract, leveraging the gut-brain axis—a bidirectional communication pathway between the gut microbiota and the brain. By producing GABA locally in the gut, Lp815™ may influence central nervous system function and mood regulation, providing a dual pathway for enhancing GABA levels. This sustained production is particularly beneficial compared to traditional GABA supplements, which often require multiple doses throughout the day due to their transient effects. The prolonged release profile of GABA Probiotic reduces the need for frequent redosing, thereby offering a more convenient and consistent option for patients seeking to manage stress and support mood stability. SAFFRON EXTRACT (AS AFFRON®) We also included affron® Saffron Extract, which is a highly acclaimed and extensively researched form of saffron, recognized for its rapid and comprehensive effects on both brain and body health. This premium extract has been shown to work within approximately one hour, delivering significant benefits such as reduced oxidative stress, balanced neurotransmitter levels, enhanced neuroplasticity, and improvements in memory and sexual function. Clinical evidence supports affron® as the most studied saffron extract with eight human clinical studies, demonstrating its ability to improve mood in healthy adults experiencing occasional stress,  anxiety and shown to support restful sleep through multiple mechanisms.  In a randomized, double-blind, placebo-controlled study, participants who consumed 28 mg/day of affron® for four weeks experienced a 41% improvement in mood, along with a significant reduction in occasional stress, frustration, and tension compared to the placebo group.  It promotes relaxation and reduces pre-sleep anxiety by modulating cortisol and serotonin levels, helping calm mental overactivity that can interfere with falling asleep. Affron® has been shown to enhance overall sleep quality, reduce nighttime awakenings, and support a smoother transition into deeper sleep—without sedation or next-day grogginess. L-THEANINE (AS L-TEAACTIVE®) Theanine is an amino acid that is not commonly found in the human diet, as it is not one of the essential or nonessential amino acids. L-theanine is often called a “nondietary amino acid.” Because of its structure, theanine is known to reach the brain quickly following oral consumption. L-theanine is present in various food sources but is found mainly in both green and black teas.  Theanine is found to be relaxing, but not sedating agent, and has been found to help process stress and to improve attention. It has also been found to aid in sleep quality. L-Theanine: A Natural Supplement for supporting sleep through multiple calming, non-sedating mechanisms: Studies show that increasing intake of theanine can significantly reduce symptoms of anxiety, such as a racing heartbeat and increased secretion of immunoglobulin A in saliva. Its effects are somewhat similar to those of a sedative, but L-theanine is far from this prescription drug. It is actually considered to be an effective anxiolytic, which helps to prevent the brain from producing an anxious response to stressful situations. How Does L-Theanine for Sleep Work? L-theanine is processed in the brain through the blood-brain barrier. The blood-brain barrier is similar to a gateway that prevents blood borne substances from crossing over into the brain; it is a form of protection for one of the body’s most important organs. While this barrier is beneficial, it does have its downsides; most notably, it prevents many medications from reaching their target area. Research shows that 98% of small molecule neurotherapies, and 100 percent of large molecule neurotherapies can’t pass through the blood-brain barrier, rendering many types of common treatments for anxiety almost useless.   L-theanine is different. It uses the leucine-preferring transport system to hitch a ride across the blood-brain barrier, allowing it to target the brain directly. Essentially, theanine is better able to get to where it needs to be efficiently.  Once past the blood-brain barrier, L-theanine enacts a variety of neurophysiological and pharmacological effects. It has been found to up-regulate inhibitory neurotransmitters, and blocks the binding of L-glutamic acid to glutamate receptors in the brain. It has also been found to potentially modulate serotonin and dopamine in select areas of the brain. L-theanine’s inhibition of cortical neuron excitation can have anti-stress effects improve sleep efficiency. The three main mechanisms of how L-theanine works in the brain: 1.    Dampens the effects of excitatory brain chemicals  L-theanine is reported to target a number of glutamate receptors, including N-methyl-D-aspartate (NMDA), α-amino-3-hydroxy-5-methyl- 4-isoxazolepropionic acid (AMPA) and kainite receptors, although at a much lower affinity compared to glutamate  2.    Increases levels of calming and mood-elevating brain chemicals L-theanine also stimulates the production of the calming brain chemicals like γ-aminobutyric acid (GABA), serotonin and dopamine adding to its calming and relaxing effects without sleepiness or impaired motor function  3.    Increases alpha brain waves  This increase in alpha wave activity is thought to contribute to L-theanine’s relaxing yet alert effects. *This item may take longer to ship out*

As the science of longevity continues to evolve, more and more researchers are focusing on geroprotectors- compounds capable to have the potential to prevent or even reverse aging at the cellular level.  Telomere Prime reflects cutting-edge science, featuring a broad spectrum of ingredients that have been shown to support healthy cellular function.  The health of our cells is foundational to our overall health, so supporting our health and vitality is one of the smartest things we can do for our long-term wellbeing.  The compounds in Telomere Prime have been carefully chosen for their ability to protect and repair DNA, reduce telomere shortening and support healthy cellular function.  Telomere Prime supports genomic stability and other key indicators of healthspan and lifespan such as, antioxidant protection, body global cell health, inflammation support, and mitochondrial function. Featured Benefits:  Support the body’s natural ability to repair its own DNA.  Significantly increases telomere length in yearlong clinical trials.  Inhibit synthesis of pro-inflammatory “inflammaging” cytokines such as interleukin (IL)-6, (IL)-8, NF-KB and TNF-alpha.  Prevent cell death through inhibition of the pro-apoptotic factors.  Support your DNA’s defenses against free radical damage and activates NRF2 Activates the cell and mitochondrial renewal process Chelate divalent metal ions.  Protect against damage caused by the prooxidants ferric-NTA and β-amyloid.  Enhance the immune system by increasing the life cycle of white blood cells.  Helps reduce DNA and mitochondrial damage and protect against free radicals.  Protect against UV and gamma radiation by neutralizing radiation-induced reactive oxygen species (ROS).  ac-11® Cat's Claw Aqueous Extract (Uncaria tomentosa) ac-11® is an all-natural, safe, and effective aqueous extract of Uncaria tomentosa, a medicinal plant indigenous to the Amazon rainforest. Manufactured using a proprietary process, this extract provides a broad spectrum of health benefits, primarily directed towards systemic DNA repair, environmental stress, infection, immunosenescence and aging. Scientists have determined that when the body is subjected to external stressors such as overexposure to the Sun (UV radiation), strenuous exercise, pollution, and/or the general effects of aging, our DNA is damaged. Such cumulative DNA damage has been scientifically confirmed as a causative factor in the age-onset disease. In a series of peer-reviewed scientific and clinical studies conducted by third-party laboratories and university medical centers, ac-11® has been proven to help the body’s natural ability to repair its own DNA. The primary active ingredients of ac-11® are formed by the complex molecular chains known as CAEs (Carboxy Alkyl Esters). CAEs are responsible for approximately 90% of ac-11®’s therapeutic benefits. Studies demonstrate that this patented technology:  Increases telomere length in a cell (Patent No.: US 10,098,922B1) Helps the body’s natural ability to repair its own DNA  Enhances the immune system by increasing the life cycle of white blood cells Repairs neural function damaged by overexposure to high decibel noise Helps to normalize the expression of NF-KB, thereby regulating the cellular response to systemic inflammation Maintains telomere length and integrity during the process of cellular mitosis  Increases production of natural collagen III, a form of collagen associated with soft, supple, youthful-looking skin  ac-11® differs from all other Uncaria tomentosa extracts, most of which are sold under the common name “cat’s claw,” in that its molecular composition is distinct. Such distinction is achieved through an ultra-filtration process that produces a low weight (less than 10,000 Daltons) bioavailable, scientifically indole alkaloid free (less than 0.05 ppm) extract.   The inner bark of the plant (Uncaria tomentosa) used to manufacture ac-11® is harvested in the Amazon rainforests of Brazil and Peru utilizing an eco-friendly and renewable process.   2-HOBA (as Hobamine®) Hobamine™, or 2-hydroxybenzylamine (2-HOBA), is a naturally occurring compound in Himalayan Tartary Buckwheat that is at the forefront of new developments to support cellular health, particularly as we age. Hobamine™ (2-HOBA) works by rapidly capturing specific reactive compounds formed by oxidative stress.   This capture prevents those compounds from binding to and damaging other cellular components like proteins, lipids, or DNA and impeding normal function of the cell.   An NIH-funded study found that Hobamine™ supplementation led to positive changes in 15 inflammatory biomarkers associated with immune system balance in both younger and older adults. Hobamine™ works by scavenging pro-inflammatory reactive lipids, helping maintain immune homeostasis, and supporting your immune system's ability to stay in balance even when exposed to oxidative stressors. Hobamine™ has been shown to promote normal cell function in brain cells, blood vessels, and heart, lung, and immune cells from the effects of oxidative stress, which helps to support healthy function. Hobamine™ is an emerging solution for anyone experiencing the signs of premature aging due to oxidative stress. L-Ergothioneine (as MitoPrime®) NEW higher dose: Ergothioneine is a unique amino acid, synthesized by bacteria and fungi, with mushrooms being the richest dietary source. Since its discovery over a century ago, ergothioneine’s distinctive properties have fascinated researchers, leading to growing evidence of its powerful cellular protective capabilities. Recent studies suggest that ergothioneine is a full-spectrum cyto-restorative, defending and repairing cells—including critical structures like DNA and mitochondria—against a wide range of endogenous and exogenous stressors. Its high concentration in mitochondria points to a specialized role in shielding mitochondrial DNA from oxidative damage, a key factor in aging and cellular dysfunction. Oral supplementation of ergothioneine has been shown to significantly raise its levels in plasma and whole blood, ensuring systemic protection. In a pivotal study, cells exposed to oxidative stress and treated with ergothioneine exhibited remarkable telomere lengthening and a reduction in telomere shortening after just eight weeks. Moreover, ergothioneine treatment boosted telomerase activity—the enzyme responsible for maintaining telomere length—which plays a critical role in cellular longevity. Another groundbreaking study examined the relationship between ergothioneine levels and mortality in a cohort of 3,200 Swedish adults. Among 112 compounds analyzed, ergothioneine showed the strongest association with reduced mortality. Higher blood levels of ergothioneine were linked to a significant decrease in the risk of all-cause mortality, cardiovascular-related deaths, and the development of heart disease. These compelling findings have led to ergothioneine being referred to as the ‘longevity vitamin,’ underscoring its potential as a powerful contributor to healthspan and lifespan. Spermidine (as Puremidine®) NEW higher dose: Spermidine is a polyamine compound found naturally in most living organisms and certain foods.  It has been studied for its potential health benefits since the early 1970’s.  Spermidine is believed to have anti-aging properties that can protect against cellular damage and enhance cell function.  Research has shown that it may improve heart health, increase longevity, and support healthy inflammation levels through the body.  Studies have also demonstrated that spermidine can help boost cognitive function and memory by stimulating the release of brain-derived neurotropic factor (BDNF) and increasing the number of synaptic connections in the brain.  Another potential benefit of spermidine is its ability to reduce oxidative stress and improve mitochondrial function.  Spermidine has been shown to help protect our cells from damage of aging, which leads to a host of age-related disease.  Research has shown that when spermidine is supplemented, it can help lengthen telomeres and restore their protective effects.  It also helps improve cell metabolism, which can result in increased energy production and better overall health.  Sulforaphane Glucosinolate (as Activated BroccoRaphanin®) Sulforaphane, an isothiocyanate derived from the metabolite glucoraphanin, is a powerful phytonutrient found in cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage. Extensive research has highlighted sulforaphane’s numerous health benefits, particularly its ability to reduce oxidative stress and regulate inflammation, two key factors in chronic disease and aging. In addition to its therapeutic potential, sulforaphane has been studied for its ability to enhance the body’s natural defense systems. It activates a range of protective enzymes that shield cells and DNA from damage caused by environmental stressors and toxins. This activation promotes the body’s innate detoxification processes, helping to eliminate harmful substances at the cellular level. A key component in this process is the enzyme myrosinase, which is essential for the conversion of glucoraphanin to sulforaphane. This enzyme, present in cruciferous plants, is released during chewing or chopping, initiating the activation of sulforaphane. In products like Telomere Prime, the inclusion of myrosinase ensures optimal conversion and bioavailability of sulforaphane, maximizing its protective and detoxifying effects. PQQ (Pyrroloquinoline Quinone) NEW addition: Pyrroloquinoline quinone (PQQ) is a potent bioactive compound known for its significant role in promoting cellular health, particularly in the context of telomere maintenance, DNA repair, longevity, and mitochondrial function. Research indicates that PQQ may enhance telomerase activity, the enzyme responsible for preserving telomere length, thereby supporting cellular aging and longevity. Additionally, PQQ exhibits strong antioxidant properties that help mitigate oxidative stress, a major contributor to DNA damage, thereby facilitating efficient DNA repair mechanisms. Furthermore, PQQ is crucial for mitochondrial health, as it promotes mitochondrial biogenesis—the formation of new mitochondria—and protects existing ones from oxidative damage, ensuring optimal energy production within cells. Collectively, these actions position PQQ as a valuable compound for enhancing healthspan and combating age-related cellular decline. AstraGin® (Astragalus membranaceus and Panax notoginseng) root extracts containing astragaloside I, II, IV and ginsenoside Rb1 NEW addition: AstraGin® is a proprietary, plant-derived compound complex, developed using advanced pharmaceutical extraction and processing technologies. It works by upregulating the mRNA and protein expression of key nutrient transporters in the gut, optimizing the absorption of vital nutrients and plant compounds. Extensive research, including 16 in vitro and 8 in vivo studies published in respected journals such as Journal of Agricultural and Food Chemistry, Molecular Nutrition & Food Research, and Scientific Reports, highlights AstraGin®'s potent benefits. Astragalus membranaceus and Panax notoginseng are two revered medicinal plants whose root extracts contain bioactive compounds such as astragaloside I, II, IV, and ginsenoside Rb1, which have shown promise in promoting telomere health and supporting healthy aging. Astragalosides, particularly astragaloside IV, are known to enhance telomerase activity, which helps maintain telomere length and protect against the cellular aging process. This is crucial for preserving chromosomal integrity as cells replicate. Meanwhile, ginsenoside Rb1 from Panax notoginseng exhibits antioxidant properties that mitigate oxidative stress, a major contributor to telomere shortening and age-related degeneration. Together, these compounds not only support the maintenance of telomere length but also contribute to improved cellular function, enhanced immune response, and overall vitality. Buckwheat Peptides The protein isolated from buckwheat have been hydrolyzed into a range of peptides.  These peptides showed diverse biological activities in vitro and in vivo.  They include trypsin inhibition, anti-aging, modulating gut microbiota, heart, and immune support.   Telomere Prime showcases the latest advancements in healthy aging support and features ac-11 Cat’s Claw, 2-hoba, L-ergothioneine, spermidine, sulforaphane with myrosinase and buckwheat peptides.   It is the perfect way to give your cells the boost they need to stay health and support your overall health as you age.  So, if you are looking for a natural way to support your longevity, Telomere Prime is part of your solution.  *This item may take longer to ship out*

Thymosin Beta-4-Frag 500+ is a synergistic blend of Acetyl-N-Ser-Asp-Lsy-Pro (AcSDKP), and Thymogen (Glu-Trp). These are orally enhanced with salcaprozate sodium (SNAC) . The fragment featured in this formula has been found to be 10x more potent compared to the full-length TB-4 by weight.  Research has confirmed its regenerative potential, immune modulation, supportive role for gut health, inflammaging and fibrosis. Salcaprozate sodium, or SNAC, is one of the most advanced intestinal permeation enhancers that has been tested in clinical trials for oral delivery of macromolecules. It was originally designed for the oral delivery of insulin. In one study, SNAC increased the absorption of a short chain of amino acids nine-fold without affecting tight junctions. Healthgevity's formulation includes an optimal ratio of salcaprozate sodium to our active ingredients. This combination results in exceptional oral absorption without compromising its stability or efficacy. *This item may take longer to ship out*

Alkaline Complex was created by Dr. Erica Lehman who has been working in the holistic medical field for 18 years. Prior to that Dr. Lehman could be found in the Operating Room transplanting corneas, removing cataracts and treating complex infections of the eye and surrounding structures. For the past 15 years Dr. Lehman has devoted her practice to treating tick borne disease patients, auto-immune diseases, parasites, mycotoxin illness, hormone imbalances, Candida, and complex chronic illnesses. Part of her approach to treating the inflammation that accompanies these conditions includes balancing the pH of the body.  Alkaline Complex is combination of minerals that diminish the overall acidity of the body. Low pH (acidity) causes inflammation and pain which further increases symptoms and decreases the body's ability to facilitate healing. Our unique and balanced combination of alkalizing minerals is ideal for supporting detoxification, chronic pain and inflammation, Herxheimer reactions and overall wellness. *This item may take longer to ship out*