{"id":9037111492828,"title":"RESOLVE+ 60 Caps *","handle":"resolve-60-caps","description":"\u003cdiv class=\"product-single__description rte\"\u003e\n\u003cp\u003e\u003cspan\u003eAging is characterized by an increase in the concentration of inflammatory markers in \u003c\/span\u003e\u003cspan\u003ethe blood- stream, a phenomenon that has been termed “inflammaging”. The inflammatory response is beneficial as an acute, transient reaction to harmful conditions, facilitating the defense, repair, turnover and adaptation of many tissues. However, chronic and low-grade inflammation is likely to be detrimental for many tissues and for normal functions. Our team investigated various natural solutions targeting multiple influences of inflammaging. \u003cstrong\u003eResolve+ \u003c\/strong\u003econtains numerous compounds that have been found to reduce the inflammatory response by targeting a variety of mechanisms.\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003eAcmella oleracea\u003c\/strong\u003e \u003c\/em\u003e(“jambu”) is sourced from \u003cem\u003eSardinia, Italy and \u003c\/em\u003erich in alkylamides mainly represented by spilanthol. Its flowers are widely used in folk medicine to treat toothache due to tingling, numbness, and local anesthesia caused in the mouth.\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003e\u003cem\u003eAcmella oleracea\u003c\/em\u003e\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003ehas been shown to be active in fatty acid amide hydrolase (FAAH) inhibition the enzyme responsible for the degradation of fatty acid amides\u003cspan\u003e \u003c\/span\u003eand cannabinoid type 2\u003cspan\u003e(\u003c\/span\u003eCB2) activation.\u003cspan\u003e \u003c\/span\u003eThere are almost 100 studies suggesting the supportive potential for anti-inflammatory, antioxidant, and analgesic effects of \u003cstrong\u003eAcmella\u003c\/strong\u003e. Studies reported in this review confirmed activities of \u003cstrong\u003eAcmella\u003c\/strong\u003e, postulating that transcription factors of the nuclear factor-κB family (NF-κB) trigger the transcription iNOS and COX-2 and several other pro-inflammatory mediators, such as IL-6, IL-1β, and TNF-α.\u003c\/p\u003e\n\u003cp\u003eCurcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L.), has been well documented to exhibit various health benefits. There have been many claims on the health benefits of curcumin on neurological, cardiovascular, lung, metabolic, and liver function, mainly through its anti-inflammatory and antioxidant properties. Despite its promising potential, the clinical application of curcumin has been limited due to its low bioavailability.\u003c\/p\u003e\n\u003cp\u003eTo enhance curcumin absorption, we are the first to feature \u003cstrong\u003eTheracurmin Super® 85X\u003c\/strong\u003e, a proprietary curcumin utilizing the latest technology that transforms standard curcumin into an amorphous structure. \u003cstrong\u003eTheracurmin Super® 85X\u003c\/strong\u003e uses the latest technology to transform regular curcumin particles into a more bioavailable structure. This is done by splitting curcumin particles’ crystal structure amorphous, therefore, making it easily absorbed and bioavailable to maximize its supportive potential.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTetrahydrocurcumin\u003c\/strong\u003e (4-HC) is the key\u003cspan\u003e \u003c\/span\u003ebioactive derivative\u003cem\u003e \u003c\/em\u003eof curcumin, it’s also given credibility as the \u003cem\u003eengine\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003ebehind all that curcumin brings to the table. With a newfound ability to extract and isolate the compound, research has even seen \u003cstrong\u003etetrahydrocurcumin\u003c\/strong\u003e outperform its parent compound in several tests of its capabilities. Researchers have also confirmed that\u003cspan\u003e \u003c\/span\u003e4-HC attenuated pro-inflammatory indicators\u003cem\u003e like \u003c\/em\u003einterleukin-1, interleukin-6, TNF-⍺\u003cem\u003e, and \u003c\/em\u003eprostaglandin E2. \u003cspan\u003e \u003c\/span\u003eAfter reviewing the data, we found many advantages to infuse tetrahydrocurcumin as \u003cstrong\u003eCurcuPrime®\u003c\/strong\u003estacked with \u003cstrong\u003eTheracurmin Super® 85X\u003c\/strong\u003e into \u003cstrong\u003eResolve+.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQuercetin\u003c\/strong\u003e is a well-known studied dietary flavonoid ubiquitously present in various vegetables. \u003cstrong\u003eQuercetin\u003c\/strong\u003e is known for its antioxidant activity in radical scavenging and anti-allergic properties characterized by stimulation of immune system, antiviral activity, inhibition of histamine release, decrease in pro-inflammatory cytokines, leukotrienes creation, and suppresses interleukin IL-4 production. \u003cspan\u003e \u003c\/span\u003eMultiple studies have confirmed its supportive potential as an immune modulator and its ability to support a healthy inflammatory response. It can improve the Th1\/Th2 balance, and restrain antigen specific IgE antibody formation However, chemical instability, poor water solubility and low bioavailability of \u003cstrong\u003equercetin\u003c\/strong\u003e greatly limit its applications which is why a phytosome technology which we feature in resolve is the preferred delivery system to overcome these limitations. This enhanced form of \u003cstrong\u003equercetin\u003c\/strong\u003e has been shown to be as much as 20 times better absorbed than other \u003cstrong\u003equercetin\u003c\/strong\u003e options. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCasperome® boswellia phytosome\u003c\/strong\u003e is a potent extract made from the resin of Boswellia serrata trees and is also referred as Indian frankincense. Boswellia extracts have been demonstrated to be effective in the management of various inflammatory response functions including those that occur in the bowel, joints, bones, respiratory airways and in the brain. The mechanism of action that involves the modulation of the natural inflammatory response both acting on prostanoid synthesis (mPGE2S) and protein degradation (caspases), and transcription factors (Nf-κB).\u003cspan\u003e \u003c\/span\u003eWe have selected \u003cstrong\u003eCasperome\u003c\/strong\u003e\u003cstrong\u003e® \u003c\/strong\u003ewhich is a highly standardized in boswellic acids to match the natural composition of boswellia, formulated with phytosome technology to achieve optimized absorption and has been validated by over 10 human studies.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePerilla \u003cem\u003efrutescens \u003c\/em\u003e\u003c\/strong\u003eis an annual herb belonging to the mint family (Lamiaceae). It is mainly produced in countries like China, Japan, India, Thailand and Korea. Recently, \u003cstrong\u003ePerilla\u003c\/strong\u003e is gaining more attention because of its medicinal benefits and phytochemical contents. The functional compounds of \u003cstrong\u003ePerilla Seed Extract\u003c\/strong\u003e are flavonoid Aglycons – polyphenols such as Luteolin, Apigenin, Chrysoeriol, and Rosemarinic Acid\u003cspan\u003e.\u003c\/span\u003e Studies have shown that \u003cstrong\u003ePerilla\u003c\/strong\u003e seed polyphenols regulate allergic and inflammatory response due to its 5-lipoxygenase inhibitory activity and suppression potential of histamine release from mast cells.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAstraGin\u003csup\u003e®\u003c\/sup\u003e\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eis a natural compound derived from the roots of two traditional Chinese herbs: Panax notoginseng and Astragalus membranaceous which contain astragaloside I, II, IV and ginsenoside Rb1.\u003cspan\u003e \u003c\/span\u003eA\u003cstrong\u003estraGin\u003csup\u003e®\u003c\/sup\u003e\u003c\/strong\u003e\u003cspan\u003e has been shown to \u003c\/span\u003eprovide full-spectrum gut support through enhanced absorption, microbiota and immune cell viability, and supporting a health. \u003cstrong\u003eAstraGin\u003csup\u003e®\u003c\/sup\u003e\u003c\/strong\u003e\u003cspan\u003e has\u003c\/span\u003e been shown in numerous studies to increase the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up regulating the absorption specific mRNA and transporters, such as SGLT1, CAT1, and GLUT4. Additionally, \u003cstrong\u003eAstraGin\u003c\/strong\u003e\u003csup\u003e\u003cstrong\u003e®\u003c\/strong\u003e \u003c\/sup\u003e\u003cspan\u003ewas\u003c\/span\u003e shown to reduce intestinal inflammatory biomarker MPO, the pro-inflammatory cytokines IL-6, IL-17, and IL-1β in ulcerative colitis patients.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(255, 42, 0); font-size: 0.875rem;\"\u003e*This item may take longer to ship out*\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003c\/div\u003e","published_at":"2025-08-18T17:37:19-05:00","created_at":"2025-08-18T17:35:31-05:00","vendor":"Healthgevity","type":"Supplement","tags":["Anti-inflammatory","Antioxidant","Antioxidant Activity","antioxidant protection","Cellular Health","Immune","Immune Health","Inflammation Support","Oxidative Stress"],"price":7999,"price_min":7999,"price_max":7999,"available":true,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":46835437666524,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":null,"requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"RESOLVE+ 60 Caps *","public_title":null,"options":["Default Title"],"price":7999,"weight":170,"compare_at_price":null,"inventory_management":"shopify","barcode":null,"requires_selling_plan":false,"selling_plan_allocations":[],"quantity_rule":{"min":1,"max":null,"increment":1}}],"images":["\/\/shop.connersclinic.com\/cdn\/shop\/files\/resolve-60-caps-healthgevity-conners-clinic-1186045510.png?v=1755564556","\/\/shop.connersclinic.com\/cdn\/shop\/files\/resolve-60-caps-healthgevity-conners-clinic-1186045509.png?v=1755564553","\/\/shop.connersclinic.com\/cdn\/shop\/files\/resolve-60-caps-healthgevity-conners-clinic-1186045508.png?v=1755564549"],"featured_image":"\/\/shop.connersclinic.com\/cdn\/shop\/files\/resolve-60-caps-healthgevity-conners-clinic-1186045510.png?v=1755564556","options":["Title"],"media":[{"alt":"RESOLVE+ 60 Caps * Healthgevity Supplement - Conners Clinic","id":35421534978268,"position":1,"preview_image":{"aspect_ratio":0.504,"height":1056,"width":532,"src":"\/\/shop.connersclinic.com\/cdn\/shop\/files\/resolve-60-caps-healthgevity-conners-clinic-1186045510.png?v=1755564556"},"aspect_ratio":0.504,"height":1056,"media_type":"image","src":"\/\/shop.connersclinic.com\/cdn\/shop\/files\/resolve-60-caps-healthgevity-conners-clinic-1186045510.png?v=1755564556","width":532},{"alt":"RESOLVE+ 60 Caps * Healthgevity Supplement - Conners Clinic","id":35421535305948,"position":2,"preview_image":{"aspect_ratio":0.773,"height":1356,"width":1048,"src":"\/\/shop.connersclinic.com\/cdn\/shop\/files\/resolve-60-caps-healthgevity-conners-clinic-1186045509.png?v=1755564553"},"aspect_ratio":0.773,"height":1356,"media_type":"image","src":"\/\/shop.connersclinic.com\/cdn\/shop\/files\/resolve-60-caps-healthgevity-conners-clinic-1186045509.png?v=1755564553","width":1048},{"alt":"RESOLVE+ 60 Caps * Healthgevity Supplement - Conners Clinic","id":35421535600860,"position":3,"preview_image":{"aspect_ratio":1.106,"height":1002,"width":1108,"src":"\/\/shop.connersclinic.com\/cdn\/shop\/files\/resolve-60-caps-healthgevity-conners-clinic-1186045508.png?v=1755564549"},"aspect_ratio":1.106,"height":1002,"media_type":"image","src":"\/\/shop.connersclinic.com\/cdn\/shop\/files\/resolve-60-caps-healthgevity-conners-clinic-1186045508.png?v=1755564549","width":1108}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003cdiv class=\"product-single__description rte\"\u003e\n\u003cp\u003e\u003cspan\u003eAging is characterized by an increase in the concentration of inflammatory markers in \u003c\/span\u003e\u003cspan\u003ethe blood- stream, a phenomenon that has been termed “inflammaging”. The inflammatory response is beneficial as an acute, transient reaction to harmful conditions, facilitating the defense, repair, turnover and adaptation of many tissues. However, chronic and low-grade inflammation is likely to be detrimental for many tissues and for normal functions. Our team investigated various natural solutions targeting multiple influences of inflammaging. \u003cstrong\u003eResolve+ \u003c\/strong\u003econtains numerous compounds that have been found to reduce the inflammatory response by targeting a variety of mechanisms.\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e \u003c\/span\u003e\u003cem\u003e\u003cstrong\u003eAcmella oleracea\u003c\/strong\u003e \u003c\/em\u003e(“jambu”) is sourced from \u003cem\u003eSardinia, Italy and \u003c\/em\u003erich in alkylamides mainly represented by spilanthol. Its flowers are widely used in folk medicine to treat toothache due to tingling, numbness, and local anesthesia caused in the mouth.\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003e\u003cem\u003eAcmella oleracea\u003c\/em\u003e\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003ehas been shown to be active in fatty acid amide hydrolase (FAAH) inhibition the enzyme responsible for the degradation of fatty acid amides\u003cspan\u003e \u003c\/span\u003eand cannabinoid type 2\u003cspan\u003e(\u003c\/span\u003eCB2) activation.\u003cspan\u003e \u003c\/span\u003eThere are almost 100 studies suggesting the supportive potential for anti-inflammatory, antioxidant, and analgesic effects of \u003cstrong\u003eAcmella\u003c\/strong\u003e. Studies reported in this review confirmed activities of \u003cstrong\u003eAcmella\u003c\/strong\u003e, postulating that transcription factors of the nuclear factor-κB family (NF-κB) trigger the transcription iNOS and COX-2 and several other pro-inflammatory mediators, such as IL-6, IL-1β, and TNF-α.\u003c\/p\u003e\n\u003cp\u003eCurcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L.), has been well documented to exhibit various health benefits. There have been many claims on the health benefits of curcumin on neurological, cardiovascular, lung, metabolic, and liver function, mainly through its anti-inflammatory and antioxidant properties. Despite its promising potential, the clinical application of curcumin has been limited due to its low bioavailability.\u003c\/p\u003e\n\u003cp\u003eTo enhance curcumin absorption, we are the first to feature \u003cstrong\u003eTheracurmin Super® 85X\u003c\/strong\u003e, a proprietary curcumin utilizing the latest technology that transforms standard curcumin into an amorphous structure. \u003cstrong\u003eTheracurmin Super® 85X\u003c\/strong\u003e uses the latest technology to transform regular curcumin particles into a more bioavailable structure. This is done by splitting curcumin particles’ crystal structure amorphous, therefore, making it easily absorbed and bioavailable to maximize its supportive potential.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTetrahydrocurcumin\u003c\/strong\u003e (4-HC) is the key\u003cspan\u003e \u003c\/span\u003ebioactive derivative\u003cem\u003e \u003c\/em\u003eof curcumin, it’s also given credibility as the \u003cem\u003eengine\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003ebehind all that curcumin brings to the table. With a newfound ability to extract and isolate the compound, research has even seen \u003cstrong\u003etetrahydrocurcumin\u003c\/strong\u003e outperform its parent compound in several tests of its capabilities. Researchers have also confirmed that\u003cspan\u003e \u003c\/span\u003e4-HC attenuated pro-inflammatory indicators\u003cem\u003e like \u003c\/em\u003einterleukin-1, interleukin-6, TNF-⍺\u003cem\u003e, and \u003c\/em\u003eprostaglandin E2. \u003cspan\u003e \u003c\/span\u003eAfter reviewing the data, we found many advantages to infuse tetrahydrocurcumin as \u003cstrong\u003eCurcuPrime®\u003c\/strong\u003estacked with \u003cstrong\u003eTheracurmin Super® 85X\u003c\/strong\u003e into \u003cstrong\u003eResolve+.\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eQuercetin\u003c\/strong\u003e is a well-known studied dietary flavonoid ubiquitously present in various vegetables. \u003cstrong\u003eQuercetin\u003c\/strong\u003e is known for its antioxidant activity in radical scavenging and anti-allergic properties characterized by stimulation of immune system, antiviral activity, inhibition of histamine release, decrease in pro-inflammatory cytokines, leukotrienes creation, and suppresses interleukin IL-4 production. \u003cspan\u003e \u003c\/span\u003eMultiple studies have confirmed its supportive potential as an immune modulator and its ability to support a healthy inflammatory response. It can improve the Th1\/Th2 balance, and restrain antigen specific IgE antibody formation However, chemical instability, poor water solubility and low bioavailability of \u003cstrong\u003equercetin\u003c\/strong\u003e greatly limit its applications which is why a phytosome technology which we feature in resolve is the preferred delivery system to overcome these limitations. This enhanced form of \u003cstrong\u003equercetin\u003c\/strong\u003e has been shown to be as much as 20 times better absorbed than other \u003cstrong\u003equercetin\u003c\/strong\u003e options. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCasperome® boswellia phytosome\u003c\/strong\u003e is a potent extract made from the resin of Boswellia serrata trees and is also referred as Indian frankincense. Boswellia extracts have been demonstrated to be effective in the management of various inflammatory response functions including those that occur in the bowel, joints, bones, respiratory airways and in the brain. The mechanism of action that involves the modulation of the natural inflammatory response both acting on prostanoid synthesis (mPGE2S) and protein degradation (caspases), and transcription factors (Nf-κB).\u003cspan\u003e \u003c\/span\u003eWe have selected \u003cstrong\u003eCasperome\u003c\/strong\u003e\u003cstrong\u003e® \u003c\/strong\u003ewhich is a highly standardized in boswellic acids to match the natural composition of boswellia, formulated with phytosome technology to achieve optimized absorption and has been validated by over 10 human studies.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePerilla \u003cem\u003efrutescens \u003c\/em\u003e\u003c\/strong\u003eis an annual herb belonging to the mint family (Lamiaceae). It is mainly produced in countries like China, Japan, India, Thailand and Korea. Recently, \u003cstrong\u003ePerilla\u003c\/strong\u003e is gaining more attention because of its medicinal benefits and phytochemical contents. The functional compounds of \u003cstrong\u003ePerilla Seed Extract\u003c\/strong\u003e are flavonoid Aglycons – polyphenols such as Luteolin, Apigenin, Chrysoeriol, and Rosemarinic Acid\u003cspan\u003e.\u003c\/span\u003e Studies have shown that \u003cstrong\u003ePerilla\u003c\/strong\u003e seed polyphenols regulate allergic and inflammatory response due to its 5-lipoxygenase inhibitory activity and suppression potential of histamine release from mast cells.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAstraGin\u003csup\u003e®\u003c\/sup\u003e\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eis a natural compound derived from the roots of two traditional Chinese herbs: Panax notoginseng and Astragalus membranaceous which contain astragaloside I, II, IV and ginsenoside Rb1.\u003cspan\u003e \u003c\/span\u003eA\u003cstrong\u003estraGin\u003csup\u003e®\u003c\/sup\u003e\u003c\/strong\u003e\u003cspan\u003e has been shown to \u003c\/span\u003eprovide full-spectrum gut support through enhanced absorption, microbiota and immune cell viability, and supporting a health. \u003cstrong\u003eAstraGin\u003csup\u003e®\u003c\/sup\u003e\u003c\/strong\u003e\u003cspan\u003e has\u003c\/span\u003e been shown in numerous studies to increase the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up regulating the absorption specific mRNA and transporters, such as SGLT1, CAT1, and GLUT4. Additionally, \u003cstrong\u003eAstraGin\u003c\/strong\u003e\u003csup\u003e\u003cstrong\u003e®\u003c\/strong\u003e \u003c\/sup\u003e\u003cspan\u003ewas\u003c\/span\u003e shown to reduce intestinal inflammatory biomarker MPO, the pro-inflammatory cytokines IL-6, IL-17, and IL-1β in ulcerative colitis patients.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(255, 42, 0); font-size: 0.875rem;\"\u003e*This item may take longer to ship out*\u003c\/span\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003c\/div\u003e"}