Immune Support

A Simple Plant with Unprecedented Benefits Over 70% of our immune system is found in the gut. Our proprietary Acemannan Aloe vera extract provides a unique formulation of the most powerful immune-balancing fractions of Acemannan to provide the body with targeted immune support where it counts — in the gut. A proprietary concentration of the most immune-activating Acemannan fractions from the inner leaf gel of the Aloe vera plant “Smart” immune-modulating impact may help the body lower overactive immune systems or activate sluggish ones Evolv / Alovea Immūn is a state-of-the-art Aloe vera inner leaf gel powder containing the most immune-activating fractions of Acemannan, making it a powerful addition to your program to support the body’s immune function. Studies have shown Acemannans with a molecular weight of 400 KDa or less are powerful immune cell activators, while those at more than 400 KDa support only a little immunomodulatory activity. Acemannans with a molecular weight of less than 50 KDa can be absorbed immediately through the intestinal walls and into the bloodstream, where they are transported throughout the body. Immune cells in the gut help to direct various immune responses. When they are properly activated, they are very able to self-regulate to keep the immune system from getting too high or too low, called “immunomodulation.” Acemannan helps the body modulate (balance) its immune response, which supports optimal immune effectiveness. Evolv Immūn Acemannan supplement offers some of the best integrative health support to those immune cells by providing the highest concentration of immune-activating Acemannan fractions available on the market today. Throughout the 1990s and early 2000s, the processing of stabilized Acemannan changed very little. Then, in the early 2005, the discovery was made that only specifically-sized fractions of Acemannan (Aloe vera’s bio- active molecule) were small enough to be absorbed directly into the blood stream, and other slightly larger fractions actually facilitated the plant’s amazing immunomodulatory effect. The larger fractions of Acemannan are converted to short chain fatty acids that provide additional gut health support. With this new information, Dr. Santiago Rodriguez, one of the world’s leading experts on Aloe Acemannan processing, developed Evolv Immūn, a revolutionary new Aloe Vera extract with a proprietary concentration of these immune activating and bioavailable Acemannan fractions, offering consumers an effective, non-toxic integrative health strategy for supporting the body’s normal functions of defense, repair, and regeneration.

This may be fulfilled by a product that this manufacturer Private Labels for us When you’re choosing to decrease the levels of histamine in your diet, it’s just that: decreasing. It is simply impossible (and actually unnecessary) to try to eliminate histamines. They’re everywhere. However what you can do, and should focus on, is reducing your intake of high histamine foods along with combining foods that are low in histamine with other foods can help break down and clear histamine from the body. Use this list to help lower your histamine load. Using products like our Histamine Scavenger can greatly reduce one's symptoms of excess histamine. This is one of our BEST selling products with the number of people RE-purchasing at the highest - meaning...it WORKS! On SALE this month - $3.00 off per bottle!!!! Ingredients: Larch Tree Fiber Pine Bark Extract Aloe Vera Leaf Quercetin Bromelain Nettle Leaf Marshmallow Root Bitter Orange Licorice Sugar free, salt free, starch free, preservative free, no artificial colors or flavors or additives, wheat free, soy free, yeast free, no milk derivatives Potential Benefits: Supports normal histamine levels Reduce inflammatory responses to non-allergen exposures Can help the body repair leaky gut, or prevent its onset Supports ABP1 & HNMT gene pathways Description: Histamine is a versatile, yet unique, compound that naturally interacts with several physiological pathways. Typically, bodily injury and antigen exposure promotes the release of histamine. A white blood cell variation known as a basophil and similarly constructed mast cells, found in connective tissue, are the main producers of histamine. Despite various origins and locations, histamine compounds found outside of the CNS contribute to a universal goal: initiating an inflammatory response. Histamine, as a result of corresponding neural receptors, has the potential for profound effects on the hypothalamus and other neurotransmitters: specifically effecting appetite and sleep patterns. Therefore, increased histamine can disrupt usual compound levels in the CNS.  Secreted histamine also promotes vasodilation, blood plasma release from adjacent blood vessels, and stimulates gastric acid production. Vasodilation allows for greater capillary permeability; therefore, white blood cells are capable of contacting pathogens found in interstitial fluid, also potentially effecting intestinal permeability.  Excessive histamine can be correlated to genetic mutations, leaky gut, allergies, and an individual’s diet. Studies have suggested gliadin, a protein found in wheat, to be involved with mast cell function and secretion of histamine; similarly, gliadin also stimulates the release of Zonulin. Under further observation, Zonulin has been found, during an ex vivo study, to increase intestinal permeability, serving as another contributor to a leaky gut.  Genetic mutations found in the ABP1 and HNMT genes are potential indicators for elevated histamine. Furthermore, increased histamine levels can result in heart palpitations, low blood pressure, hypertension, fatigue, anxiety, joint pain, irritable bowel syndrome, stomach ulcers, adrenal gland fatigue, and altered sleep patterns. Histamine Scavenger contains the essential ingredients believed to promote the reduction of harmful histamine accumulation.   Genetic supplementation is complex and requires a deep understanding of the entire genetic picture.  Our Genetics Membership includes the kit, a full workup, review, report, summary, Dr. Conners’ personalized recommendations - and MORE.  Click HERE for details.   Histamine Scavenger is designed to reduce histamine (an inflammatory chemical) in the tissues.

Conners Originals Apop-E 300 is a unique tocopherol-free, tocotrienols-only product, featuring tocotrienols sourced from the annatto tree. Annatto is the richest known source of tocotrienols, containing 100% tocotrienols (90% delta and 10% gamma isomers), with no tocopherols.Commercial vitamin E supplements are typically rich in tocopherols and low or absent in tocotrienols; however, tocotrienol fractions have unique beneficial effects across a variety of tissues that make them desirable for supporting many aspects of health. Research indicates that tocopherols—especially alpha-tocopherol—may interfere with key therapeutic effects of tocotrienols, so it may be best to dose tocotrienols alone, without tocopherols. Vitamin E is not a single nutrient, but rather a complex consisting of 4 tocopherols and 4 tocotrienols. Each of these components has a different molecular weight and slightly different chemical structure, which impart distinct properties that influence their biochemical functions. Apop-E 300 features DeltaGold®, a patented annatto tocotrienol formula produced in the US by American River Manufacturing.  Ingredients:  Vitamin E Isomers Made with non-GMO ingredients.   NOTE: All of the above statements have not been evaluated by the Food and Drug Administration. This and any product(s) discussed are not intended to diagnose, treat, cure, or prevent any disease.

This may be fulfilled by a product that this manufacturer Private Labels for us By purchasing this product, you agree that you will be receiving OrthoMune in our new private-labeled bottle: Clear CV - Our own private labeled OrthoMune! By having Orthomolecular private label their great products for us, we are able to offer them to more people and receive/ship product in a more timely manner so YOU can get what you want, faster!!! OrthoMune/Clear CV is a balanced blend of flavonoids and crucial vitamins and minerals that provide safe, long-term immune support for all populations without overstimulating the immune system. OrthoMune/Clear CV is a targeted blend of nutrients designed to provide a broad-spectrum support to the body’s immune reserves. The formula includes quercetin, a powerful bioflavonoid that aids in supporting the immune system. Vitamin C and N-acetyl cysteine are potent antioxidants that promote respiratory function and support the function of quercetin. Vitamin D and zinc are important micronutrients needed to create a robust immune reserve. This powerful combination works to promote healthy respiratory and immune function. Vitamin D3 It has been shown that low vitamin D levels have immunologic implications with a significant decrease in immune function, affecting respiratory health.11,12,17 This is most likely because the vitamin D receptor is expressed by several immune cells including monocytes, macrophages, dendritic cells, B and T cells.18 Supplementation with vitamin D has been shown to modulate NK cell activity to promote a healthy innate immune response.15,19 Along with these immune-supporting benefits, vitamin D has also been shown to support the respiratory system and epithelial tight junction integrity.15,19,20,21 Zinc Zinc is essential for maintaining immune system integrity and healthy immune development.12,13,14 Supplementation with zinc supports key immune functions such as natural killer cell activity and phagocytosis by macrophages and neutrophils.15 Furthermore, studies show that zinc can directly support the body during immune system challenges and can help support healthy respiratory function.15,16 Vitamin C Vitamin C is a potent antioxidant that has been studied for many years for its immune-supporting effects. Through its antioxidant functions, vitamin C has been shown to protect important immune cells from oxidative damage.5 Data shows vitamin C is heavily concentrated in macrophages, supports lymphocyte activity, modulates cytokine release, improves endothelial function, restores mitochondrial function, and can directly support a challenged immune system.3 Of particular interest, vitamin C has been shown to recycle oxidized quercetin back to its parent compound, which supports a robust immune response while increasing the efficacy of quercetin.3,6 Quercetin Quercetin is best known for its antioxidant activity in scavenging free radicals. Additionally, quercetin helps balance the level of cytokines and improve T-lymphocyte balance. Several mechanism studies highlight quercetin’s ability to provide immune system support while also stimulating the ciliary beat frequency of the nasal epithelium, aiding the excretion of respiratory mucus.1,2,3 Quercetin has been shown to block the mechanisms by which microbes enter the host cells and replicate within the body.3 Additionally, a human clinical trial found quercetin supplementation supported healthy respiratory function following a stressor (i.e., intense bout of exercise), compared to placebo.4 N-acetyl cysteine (NAC) NAC is the precursor of the master antioxidant, glutathione. NAC has been shown to support mucus clearance and normal respiratory function, through its ability to cleave disulfide bonds in mucus.7,8 NAC is found to raise glutathione levels, which is important to protect the biologic activity and safe metabolism of quercetin.3,9 Along with protecting the activity of quercetin, NAC supports all detoxification pathways and helps maintain immune balance by supporting glutathione levels.10,11 Directions 2 capsules per day or as recommended by your health care professional.  Learn more about OrthoMune/Clear CV here >> ConnersClinic.com/blog   Studies on COVID-19 and Nutrition** US National Library of Medicine | National Institutes of Health: N-Acetylcysteine to Combat COVID-19: An Evidence Review US National Library of Medicine | National Institutes of Health: The prophylaxis and treatment potential of supplements for COVID-19 US National Library of Medicine | National Institutes of Health: Quercetin, Inflammation and Immunity FLCCC Alliance iMASK+: Preventions & Early Outpatient Treatment Protocol for COVID-19 References  1. Wu W, Li R, Li X, et al. Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry. Viruses. 2015;8(1). 2. Mehrbod P, Hudy D, Shyntum D, Markowski J, Łos MJ, Ghavami S. Quercetin as a Natural Therapeutic Candidate for the Treatment of Influenza Virus. Biomolecules. 2020;11(1). 3. Colunga Biancatelli RML, Berrill M, Catravas JD, Marik PE. Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19). Frontiers in immunology. 2020;11:1451. 4. Nieman DC, Henson DA, Gross SJ, et al. Quercetin reduces illness but not immune perturbations after intensive exercise. Med Sci Sports Exerc. 2007;39(9):1561-1569. 5. Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017;9(11). 6. Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. European journal of pharmacology. 2008;585(2-3):325-337. 7. De Rosa SC, Zaretsky MD, Dubs JG, et al. N-acetylcysteine replenishes glutathione in HIV infection. European journal of clinical investigation. 2000;30(10):915-929. 8. Aldini G, Altomare A, Baron G, et al. N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radic Res. 2018;52(7):751-762. 9. Rushworth GF, Megson IL. Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits. Pharmacology therapeutics. 2014;141(2):150-159. 10. Grandjean EM, Berthet P, Ruffmann R, Leuenberger P. Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebo-controlled clinical trials. Clinical therapeutics. 2000;22(2):209-221. 11. Falluel-Morel A, Lin L, Sokolowski K, McCandlish E, Buckley B, DiCicco-Bloom E. N-acetyl cysteine treatment reduces mercury-induced neurotoxicity in the developing rat hippocampus. J Neurosci Res. 2012;90(4):743-750. 12. Linus Pauling Institute. Zinc. 2019; https://lpi.oregonstate.edu/mic/minerals/zinc#impaired-immune-function. Accessed January 7, 2021. 13. Baum, M. K., Shor-Posner, G., Campa, A. (2000). Zinc status in human immunodeficiency virus infection. The Journal of nutrition, 130(5S Suppl), 1421S–3S. https://doi.org/10.1093/jn/130.5.1421S 14. Maares, M., Haase, H. (2016). Zinc and immunity: An essential interrelation. Archives of biochemistry and biophysics, 611, 58–65. https://doi.org/10.1016/j.abb.2016.03.022 15. Rondanelli M, Miccono A, Lamburghini S, et al. Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and Echinacea in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds-Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds. Evidence-based complementary and alternative medicine : eCAM. 2018;2018:5813095. 16. Hemilä H. Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage. JRSM open. 2017;8(5):2054270417694291. 17. Ginde AA, Sullivan AF, Mansbach JM, Camargo CA, Jr. Vitamin D insufficiency in pregnant and nonpregnant women of childbearing age in the United States. Am J Obstet Gynecol. 2010;202(5):436.e431-438. 18. Sassi F, Tamone C, D’Amelio P. Vitamin D: Nutrient, Hormone, and Immunomodulator. Nutrients. 2018;10(11). 19. Prietl B, Treiber G, Pieber TR, Amrein K. Vitamin D and immune function. Nutrients. 2013;5(7):2502-2521. 20. Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017;356:i6583. 21. Shi, Y. Y., Liu, T. J., Fu, J. H., Xu, W., Wu, L. L., Hou, A. N., Xue, X. D. (2016). Vitamin D/VDR signaling attenuates lipopolysaccharide-induced acute lung injury by maintaining the integrity of the pulmonary epithelial barrier. Molecular medicine reports, 13(2), 1186–1194. https://doi.org/10.3892/mmr.2015.4685 **Disclaimer Regarding OrthoMune This information is for educational purposes only. We are not making the claim that OrthoMune or its ingredients can prevent or fight COVID-19. It is recommended that you do your own research and consult your physician before making any decisions on what to do for your health.

NOTE: This product is a special-order product for Dr. Conners members only and NOT available to the public. NOTE: This ships in a BAG, not a jar. Conners Originals Medicinal Mushroom Mix (Miracle Mix #1) contains polysaccharides that stimulate natural killer cells (immune cells) that help your body kill intruders.  These have been used for thousands of years and science is just recently catching up with data proving their efficacy. Ingredients: Contains an equal, proprietary blend of the following powders: Graviola Maitake Mushroom Red Clover Reishi mushroom Moringa Oliefera x2 Coriolus mushroom (Turkey Tail) Cordyceps mushroom NOTE: All of the above statements have not been evaluated by the Food and Drug Administration. This and any product(s) discussed are not intended to diagnose, treat, cure, or prevent any disease. Video: Directions:  Use as directed.  This Mushroom Blend is ONLY for our patients who have been given a recommendation from Dr. Conners.

Conners Clinic Berber Clear supplies berberine combined with alpha lipoic acid to help support optimal blood sugar and insulin metabolism, cardiovascular health, and liver health. Berberine is an alkaloid compound found in the roots, rhizomes, stems, and bark of several plants commonly used in botanical and Chinese medicine, such as goldenseal, Oregon grape, barberry, and Berberis aristata. Lipoic acid is best known for its antioxidant properties and its ability to support healthy insulin metabolism and sensitivity. It is also a key cofactor for mitochondrial enzymes involved in cellular metabolism and energy (ATP) production. Ingredients: Berberine hydrochloride (from Berberis aristata) (root) Alpha Lipoic Acid Berberine Berberine is a compound found in the roots, rhizomes, stems and bark of several plants commonly used in botanical and Chinese medicine, such as goldenseal, Oregon grape, barberry, and Berberis aristata (from which its name is derived). It has become increasingly popular as people seek natural compounds that may aid in maintaining healthy blood glucose and insulin levels, without some of the adverse side-effects of pharmaceutical medications commonly used for this purpose. Berberine helps promote healthy blood glucose levels and sensitivity to insulin through multiple mechanisms.* One way berberine may aid in healthy glucose regulation is by limiting the activity of enzymes that digest carbohydrates in the small intestine, thus resulting in less glucose being absorbed into the bloodstream after meals. Alpha Lipoic Acid Alpha lipoic acid (ALA) is best known as an antioxidant. ALA is both water- and fat-soluble, meaning it exerts its antioxidant effects in different types of tissues and different compartments in the body. In addition to its antioxidant effects, ALA supports healthy insulin secretion and sensitivity, in part by facilitating the way cells take up glucose from the blood. ALA is also a key cofactor for enzymes inside the cells’ mitochondria, which is where fats, carbohydrates, and proteins are converted into energy. Thus, ALA helps support a healthy metabolism. Does Not Contain: Gluten, animal or dairy products, ingredients derived from genetically modified organisms (GMOs). Warning:  If you are on insulin treatment or taking hypoglycemic medications, consult with your healthcare practitioner before using this product.   * NOTE: All of the above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Special - save $5 per bottle! Clear CV / OrthoMune is a balanced blend of flavonoids and crucial vitamins and minerals that provide safe, long-term immune support for all populations without overstimulating the immune system. Clear CV is a targeted blend of nutrients designed to provide a broad-spectrum support to the body’s immune reserves. The formula includes quercetin, a powerful bioflavonoid that aids in supporting the immune system. Vitamin C and N-acetyl cysteine are potent antioxidants that promote respiratory function and support the function of quercetin. Vitamin D and zinc are important micronutrients needed to create a robust immune reserve. This powerful combination works to promote healthy respiratory and immune function. Vitamin D3 It has been shown that low vitamin D levels have immunologic implications with a significant decrease in immune function, affecting respiratory health.11,12,17 This is most likely because the vitamin D receptor is expressed by several immune cells including monocytes, macrophages, dendritic cells, B and T cells.18 Supplementation with vitamin D has been shown to modulate NK cell activity to promote a healthy innate immune response.15,19 Along with these immune-supporting benefits, vitamin D has also been shown to support the respiratory system and epithelial tight junction integrity.15,19,20,21 Zinc Zinc is essential for maintaining immune system integrity and healthy immune development.12,13,14 Supplementation with zinc supports key immune functions such as natural killer cell activity and phagocytosis by macrophages and neutrophils.15 Furthermore, studies show that zinc can directly support the body during immune system challenges and can help support healthy respiratory function.15,16 Vitamin C Vitamin C is a potent antioxidant that has been studied for many years for its immune-supporting effects. Through its antioxidant functions, vitamin C has been shown to protect important immune cells from oxidative damage.5 Data shows vitamin C is heavily concentrated in macrophages, supports lymphocyte activity, modulates cytokine release, improves endothelial function, restores mitochondrial function, and can directly support a challenged immune system.3 Of particular interest, vitamin C has been shown to recycle oxidized quercetin back to its parent compound, which supports a robust immune response while increasing the efficacy of quercetin.3,6 Quercetin Quercetin is best known for its antioxidant activity in scavenging free radicals. Additionally, quercetin helps balance the level of cytokines and improve T-lymphocyte balance. Several mechanism studies highlight quercetin’s ability to provide immune system support while also stimulating the ciliary beat frequency of the nasal epithelium, aiding the excretion of respiratory mucus.1,2,3 Quercetin has been shown to block the mechanisms by which microbes enter the host cells and replicate within the body.3 Additionally, a human clinical trial found quercetin supplementation supported healthy respiratory function following a stressor (i.e., intense bout of exercise), compared to placebo.4 N-Acetyl Cysteine (NAC) NAC is the precursor of the master antioxidant, glutathione. NAC has been shown to support mucus clearance and normal respiratory function, through its ability to cleave disulfide bonds in mucus.7,8 NAC is found to raise glutathione levels, which is important to protect the biologic activity and safe metabolism of quercetin.3,9 Along with protecting the activity of quercetin, NAC supports all detoxification pathways and helps maintain immune balance by supporting glutathione levels.10,11 NOTE: All of the above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.  Directions 2 capsules per day or as recommended by your health care professional.  Learn more about OrthoMune here >> ConnersClinic.com/blog   Studies on COVID-19 and Nutrition** US National Library of Medicine | National Institutes of Health: N-Acetylcysteine to Combat COVID-19: An Evidence Review US National Library of Medicine | National Institutes of Health: The prophylaxis and treatment potential of supplements for COVID-19 US National Library of Medicine | National Institutes of Health: Quercetin, Inflammation and Immunity FLCCC Alliance iMASK+: Preventions & Early Outpatient Treatment Protocol for COVID-19 References  1. Wu W, Li R, Li X, et al. Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry. Viruses. 2015;8(1). 2. Mehrbod P, Hudy D, Shyntum D, Markowski J, Łos MJ, Ghavami S. Quercetin as a Natural Therapeutic Candidate for the Treatment of Influenza Virus. Biomolecules. 2020;11(1). 3. Colunga Biancatelli RML, Berrill M, Catravas JD, Marik PE. Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19). Frontiers in immunology. 2020;11:1451. 4. Nieman DC, Henson DA, Gross SJ, et al. Quercetin reduces illness but not immune perturbations after intensive exercise. Med Sci Sports Exerc. 2007;39(9):1561-1569. 5. Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017;9(11). 6. Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. European journal of pharmacology. 2008;585(2-3):325-337. 7. De Rosa SC, Zaretsky MD, Dubs JG, et al. N-acetylcysteine replenishes glutathione in HIV infection. European journal of clinical investigation. 2000;30(10):915-929. 8. Aldini G, Altomare A, Baron G, et al. N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radic Res. 2018;52(7):751-762. 9. Rushworth GF, Megson IL. Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits. Pharmacology therapeutics. 2014;141(2):150-159. 10. Grandjean EM, Berthet P, Ruffmann R, Leuenberger P. Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebo-controlled clinical trials. Clinical therapeutics. 2000;22(2):209-221. 11. Falluel-Morel A, Lin L, Sokolowski K, McCandlish E, Buckley B, DiCicco-Bloom E. N-acetyl cysteine treatment reduces mercury-induced neurotoxicity in the developing rat hippocampus. J Neurosci Res. 2012;90(4):743-750. 12. Linus Pauling Institute. Zinc. 2019; https://lpi.oregonstate.edu/mic/minerals/zinc#impaired-immune-function. Accessed January 7, 2021. 13. Baum, M. K., Shor-Posner, G., Campa, A. (2000). Zinc status in human immunodeficiency virus infection. The Journal of nutrition, 130(5S Suppl), 1421S–3S. https://doi.org/10.1093/jn/130.5.1421S 14. Maares, M., Haase, H. (2016). Zinc and immunity: An essential interrelation. Archives of biochemistry and biophysics, 611, 58–65. https://doi.org/10.1016/j.abb.2016.03.022 15. Rondanelli M, Miccono A, Lamburghini S, et al. Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and Echinacea in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds-Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds. Evidence-based complementary and alternative medicine : eCAM. 2018;2018:5813095. 16. Hemilä H. Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage. JRSM open. 2017;8(5):2054270417694291. 17. Ginde AA, Sullivan AF, Mansbach JM, Camargo CA, Jr. Vitamin D insufficiency in pregnant and nonpregnant women of childbearing age in the United States. Am J Obstet Gynecol. 2010;202(5):436.e431-438. 18. Sassi F, Tamone C, D’Amelio P. Vitamin D: Nutrient, Hormone, and Immunomodulator. Nutrients. 2018;10(11). 19. Prietl B, Treiber G, Pieber TR, Amrein K. Vitamin D and immune function. Nutrients. 2013;5(7):2502-2521. 20. Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017;356:i6583. 21. Shi, Y. Y., Liu, T. J., Fu, J. H., Xu, W., Wu, L. L., Hou, A. N., Xue, X. D. (2016). Vitamin D/VDR signaling attenuates lipopolysaccharide-induced acute lung injury by maintaining the integrity of the pulmonary epithelial barrier. Molecular medicine reports, 13(2), 1186–1194. https://doi.org/10.3892/mmr.2015.4685 **Disclaimer Regarding Clear CV This information is for educational purposes only. We are not making the claim that Clear CV or its ingredients can prevent or fight COVID-19. It is recommended that you do your own research and consult your physician before making any decisions on what to do for your health.

Para 1 is CellCore’s flagship immune and digestive support product. Made from the Mimosa Pudica Seed, this fat-soluble supplement has the ability to deliver tangible, visible results. In the digestive tract, Mimosa Pudica seed becomes jelly-like and sticky as it scrubs the gut and grabs unwanted elements in the digestive tract.

SULFORAXYM Tomorrow’s Nutrition Pro brand SulforaXym Veggie Caps (62 count) delivers broccoli sprouts with AstraZyme. • Contains stabilized Sulforaphane & Glucoraphanin from Broccoli sprouts • Contains AstraZyme*• Contains stable Myrosinase Recommendations: Adults, as a dietary supplement, take two capsules daily. Other Ingredients: Capsule (vegetable cellulose, water). Contains clinically proven AstraZyme **: • 95% Complete protein digestion• 41% Increase in absorption of peptides• 31% Faster absorption of peptides• 60% increase in absorption of amino acids

Developed over years of clinical trials, Para 2 Immune & Digestive Support is a multi-herb formula specifically designed for powerful immune and digestive support. The proprietary blend includes multiple ingredients built to maximize the body’s ability to boost immune system function and detox.

SBI Protect is the only purified, dairy-free source of immunoglobulin G (IgG) available as a dietary supplement. Pure IgG helps to maintain a healthy intestinal immune system by binding a broad ranges of microbes and toxins within the gut lumen. Clear SBI Protect provides concentrated immunoglobulins to enhance mucosal immunity, help maintain microbial balance, support GI barrier health and integrity and also helps maintain normal inflammatory balance. Ingredients Serum-Derived Bovine (Immunoglobulin Concentrate) Immunoglobulin G (IgG) Does Not Contain Gluten, corn, yeast, artificial colors or flavors. Potential Benefits/Discussion The discovery that the gut barrier plays a key role in immune health fueled the search to strengthen it. In that search, researchers found that the binding capabilities of immunoglobulins have a positive effect on gut barrier function. Immunoglobulins bind microbes and toxins in the GI tract and eliminate them prior to immune system activation. As these unwanted triggers are removed, it resets healthy immune tolerance and builds a stronger barrier to the external environment. SBI and GI Health - SBI has been shown to bind microbes and toxins, further enhancing microbiome balance and facilitating gut barrier strength. Broad-spectrum binding capabilities demonstrate the positive influence of non-allergenic forms of immunoglobulins. As seen in several studies, SBI has the potential to bind many types of microbes and toxins. This binding and elimination decreases microbe and toxin encounters by the immune system and resets immune tolerance. SBI and Immune Health - In studies evaluating the effect of SBI on immune function, subjects showed positive outcomes in several areas, including inflammatory balance, gut barrier function and immune cell counts. In an open-label human clinical study, GI-challenged patients were given 2.5 mg SBI twice daily. They had increased CD4+ counts in the duodenum after eight weeks, indicating a regenerative effect on the tissue and immune function in the intestines. NOTE: All of the above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.  Directions Take 1 scoop (2.5 grams) in 4 ounces of water or the beverage of your choice 2 times daily or as recommended by your health care professional. Free Download - The 7 Phases of Detox

Conners Clinic Originals Hista Clear is a patented enzyme formula containing diamine oxidase (DAO) - the main enzyme responsible for the degradation of ingested histamine.  This enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract.   Our bodies are complex, and there is usually more at play than we think. What most don’t take into consideration when addressing histamine-related health issues is genetics. Whether you’re on a low histamine diet due to histamine intolerance, or simply trying to reduce high histamine foods for general health, you will benefit from understanding how your genes are related. Learn more about histamine and genetics here! Our body has two distinct methods of clearing things that could bring it harm: our immune system kills living toxins (bacteria, virus, parasites…) and our detoxification pathways clear non-living toxins (chemicals, heavy metals, drugs…). We have one other system that sits somewhere in the middle between the immune and the detoxification systems that helps with both: the mast cells. Read more about Histamine’s Double-edge Sword in the Formation and Progression of Cancer.   Ingredients: Vitamin C (ascorbic acid) Diamine Oxidase (DAO) Does Not Contain: Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or artificial preservatives. Potential Benefits: addresses excess exogenous histamine found in the folds, villi, and microvilli of the small intestine Discussion: Histamine is a bioactive or “vasoactive” amine produced in the body in response to an injury or foreign substance. It has an array of physiological effects, including increasing blood supply to specific sites in the body. In addition, histamine is involved in the immune response, regulation of gastric acid, permeability of blood vessels, contraction of muscles, and the normal response to inflammation.[1] The highest concentrations of histamine in the body are found in the gastrointestinal tract, lungs, and skin, with lesser amounts in the brain and heart.* Histamine is not only produced in the body but is also present in many fermented foods, such as sauerkraut, sausage, cheese, yogurt, and alcoholic beverages. Tuna, olives, spinach, eggplant, avocados, tomatoes, cherries, and citrus fruits are other histamine-containing foods. Despite their absence of histamine, some foods, such as berries, tea, and a variety of spices, stimulate the endogenous production of the amine due to their benzoate content. In addition, microbial fermentation can convert the histidine in high-protein foods to histamine so that the histamine content of food can increase over time.*[1] Endogenous and exogenous histamine must be broken down in order to maintain homeostasis and histamine balance. The enzyme diamine oxidase (DAO) degrades histamine by converting it from 2-(4-imidazolyl)- ethylamine to the inactive metabolite imidazole acetaldehyde.[2] The active ingredient in HistaClear is porcine-derived diamine oxidase, and research suggests that DAO derived from porcine kidney appears to have identical action to DAO derived from porcine intestine.[3] In humans and other mammals, DAO is found in high concentrations in the gastrointestinal mucosa. Animal studies suggest that circulating DAO may be a marker for mucosal integrity and maturity.[4] Certain drugs may affect histamine balance in the body by promoting histamine release or inhibiting DAO.*[2] Histamine tolerance may not be the same for everyone. Results of a double-blind, placebo-controlled crossover study suggest that tolerance to histamine can vary from individual to individual.[5] Total body histamine load must be considered when evaluating histamine tolerance, and a balance between histamine and DAO appears to be crucial to maintaining skin, rhinoconjunctival, and gastrointestinal health.[2,6] Genetic and environmental factors may interact to influence DAO expression. Ongoing research addresses the role that genetic variations may play in individual differences in DAO metabolism, and serum activity was significantly associated with seven single nucleotide variations within the DAO gene.[7,8] Histamine tolerance may be reflected in detailed questionnaires, food intake logs, trial with low-histamine diet, and measurement of DAO and histamine.*[9,10] Histamine tolerance and its manifestation may vary from organ to organ as well. A study of 39 patients suggested that intake of DAO produced a statistically significant reduction in symptoms associated with exogenous histamine ingestion, although single symptoms were not found to be reproducible.*[11] Ultimately, diminished serum DAO levels appear to be associated with changes in histamine degradation and serum histamine levels.[10] Although the mechanism of histamine degradation is uniform throughout the body, HistaClear only addresses excess exogenous histamine found in the folds, villi, and microvilli of the small intestine. HistaClear is not absorbed and therefore does not have systemic activity. A two-capsule dose of HistaClear contains 20 mg of vitamin C and 20,000 HDU (histamine degrading units) from diamine oxidase. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.* Read our article: Low Histamine Diet: The High Histamine Foods List Genetic supplementation is complex and requires a deep understanding of the entire genetic picture.  Our Genetics Membership includes the kit, a full workup, review, report, summary, Dr. Conners’ personalized recommendations - and MORE.  Click HERE for details. Video: Directions: Take 1-2 capsules no more than 15 minutes before the consumption of histamine-rich foods, or take as directed by your healthcare practitioner. Cautions: Consult your healthcare practitioner before use, especially if you are pregnant or nursing. Keep out of reach of children. Avoid if allergic to pork or any other ingredient. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.   Your browser does not support the video tag.

 SPECIAL GIFT IDEA - SAVE $10.00 PER BOTTLE Turmero Clear is a full-spectrum turmeric product that contains an exclusive blend of bioactive nutrients. It is a natural turmeric matrix standardized to contain curcuminoids, turmeric oils and turmerin protein, along with many other active turmeric compounds that deliver comprehensive support. Turmero Clear offers a well-rounded blend of turmeric phytonutrients that help support normal inflammatory balance and strengthen immune reserves. The Complete Turmeric Matrix (CTM) formula provides comprehensive benefits and supports healthy breathing, cognitive function, gut and immune function. The molecular structure of CTM contributes to its bio-efficacy and maximizes its pleiotropic effects, making it an essential support to balance various biochemical pathways in our body. The Complete Turmeric Matrix is unique to Ortho Molecular Products where bio-efficacy is maintained as the ultimate focus in driving patient outcomes. NOTE: All of the above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Natural Killer Cell Formula Transfer Factor Multi-Immune™ provides an advanced comprehensive immune support formula, promoting healthy natural killer cells, macrophage, T-cells, and cell division. Product may be used as a daily-use supplement to promote and maintain healthy natural killer cell function as well as providing additional support to the immune system during acute health challenges. Free of: Eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, soy, corn and gluten. GMO-free Suggested Use: As a dietary supplement, take three capsules away from meals (one hour before eating or two hours after eating) or as directed by your health care professional. Cautions: If pregnant or nursing, consult your health care professional before use. Frequently Asked Questions Is the Green Tea Extract decaffeinated? Our raw material specifications call for only decaffeinated green tea extract. As a result, our green tea extract contains less than 2 mg of caffeine per serving. A typical cup of drip coffee may contain 115 mg – 175 mg of caffeine. A typical chocolate bar contains 30 mg of caffeine. Is the colostrum hormone-free? Our colostrum is from cows that are not exposed to hormones. Is the bovine colostrum BSE-free? Yes. All materials of animal origin used in the preparation of this product are safe. These materials originated from sources considered being free from animal Transmissible Spongiform Encephalopathy (TSE) that includes BSE infection or contamination. It does not contain any OIE World Organization for Animal Health Specified Risk Materials. No ruminant (or other animal) material sources other than bovine lacteal secretions (colostrum/milk/milk products) are incorporated into the colostrum product. When is the best time to take this product? It is better absorbed when taken away from food. You may also take it at bedtime, if you have not eaten before going to bed. Is it OK to take this product with enzymes? No, primarily because the enzymes could adversely impact proper absorption.