Healthgevity

Featured Benefits:  Improves gastrointestinal symptoms Promotes the development of a balanced microbiome Enhances performance and muscle recovery Reduces post-workout muscle fatigue Supports joint comfort and mobility Improves muscle strength and preservation Supports the gut-muscle axis Improves vessel elasticity and blood flow We are proud to be the first global partner of Maolac™, a biotech company based in Israel who is using advanced AI and protein intelligence to develop the next generation of bioactives. Led by a team of dedicated scientists and doctors, their mission is to accelerate the world’s transition to indication-specific impact nutrition. They have developed Maolactin™, which is a proprietary AI precision system that scans all existing scientific data regarding specific proteins and their ability to promote a variety of health benefits which has assisted in the discovery of bio-functional proteins optimized for human needs. You may have heard about the remarkable health benefits of bovine colostrum. Colostrum is a nutrient- rich fluid released from the mammary glands of mammals after giving birth. Its purpose is to nourish and provide essential nutrients to their young. Colostrum supplements are known for their various health advantages, including but not limited to: Supporting Gut Health Strengthening the Immune System Aiding in Muscle Recovery Boosting Cellular Health At Healthgevity, our bioREPAIR is carefully crafted from bovine colostrum, selecting proteins with high biosimilarity to human breast milk. This ensures a superior product compared to standard bovine colostrum.  Our breakthrough formula features a proprietary delivery system that expertly mimics the protein’s natural structure found in breast milk LPPDS™ - Lipid Proteo Protective Delivery System. This is achieved through a unique microencapsulation process, ensuring that our product is functional upon absorption Maolac™ ingredients are protein-based combinations derived from bovine colostrum. Using their proprietary Maoreka™ Proteomic AI discovery platform, these combinations are meticulously tailored for specific indications. Maoreka® screens all human proteins and compares them with those found in human breast milk, utilizing AI-based technology to develop highly effective products that require low dosage consumption. Maoreka®  analyzes both amino acid sequences and 3D structures using innovative AI methods, ensuring over 95% bio-similarity with human proteins. Subsequently, they isolate these identified proteins from bovine colostrum through filtration and chromatography techniques. The result is a combination of 9-13 proteins with high biosimilarity to human breast milk, working in synergy to present a highly effective ingredient in much smaller dosages than bovine colostrum. Maolactin-GI™: a bioactive combination of several functional proteins designed to improve a range of gastrointestinal conditions. This revolutionary product acts as a long-term solution that effectively restarts gut health and helps maintain an optimal environment for the good bacteria to thrive. Maolactin-GI™ is designed to maximize gut health, repair the gut immune barrier, reduce inflammatory reactions and help fight bloating, constipation and stomach aches. This revolutionary product acts as a long-term solution that effectively restarts gut health. Maolactin-FMR™: a bioactive combination of several functional proteins designed to reduce systemic inflammation through various biological cascades, including actively promoting muscle recovery, enhancing joint comfort and better managing muscle loss.  Maolactin-FMR™ is a bioactive blend of functional proteins formulated to lower inflammation and enhance muscle recovery. This innovative ingredient assists athletes of all skill levels, as well as the anyone concerned in improving mobility and enhancing exercise recovery. Here is brief overview of the activity featured in bioREPAIR:  IgGs-like DomainIg-like Domain Containing Proteins (IGLDCPs) are a diverse group of proteins characterized by the presence of immunoglobulin-like (Ig-like) domains. These domains share structural similarities with those found in antibodies and are involved in various critical biological functions, including immune responses, cell adhesion, and molecular recognition. Their widespread presence in proteins that regulate cellular and molecular communication underscores their essential role in maintaining the body's homeostasis and overall health. Glycoproteins Glycoproteins are proteins that have carbohydrate molecules attached to them. These molecules are vital for various biological functions, including immune system modulation, cell-to-cell communication, and protein stability. Many hormones, enzymes, and antibodies are glycoproteins, which makes them crucial in maintaining overall health and facilitating physiological processes. Structural ProteinsStructural proteins provide support and shape to cells and tissues. They form the scaffolding within cells and contribute to the mechanical strength of tissues such as skin, hair, and connective tissues. Examples include collagen, elastin, and keratin, which are key to maintaining the structural integrity of the body. Thioredoxin Thioredoxin is a small protein that plays a key role in maintaining cellular redox balance. It acts as an antioxidant by facilitating the reduction of other proteins through cysteine residues, thereby protecting cells from oxidative stress. This protein is involved in various cellular processes, including DNA synthesis, repair, and regulation of cell growth. Cathelicidin Cathelicidins are a family of antimicrobial peptides that serve as part of the body's innate immune system. They help defend against bacterial, viral, and fungal infections by disrupting the integrity of microbial membranes. In addition to their antimicrobial properties, cathelicidins are involved in modulating inflammation and wound healing. Cathepsins Cathepsins are a group of proteolytic enzymes, or proteases, found in lysosomes. They play a vital role in breaking down proteins within the cell, particularly during processes like autophagy and apoptosis. Cathepsins are essential for normal cellular turnover, immune function, and tissue remodeling. This product contains dairy. 

BPC-157 is a pentadecapeptide made up of 15 amino acids that is derived from human gastric juice. It has a molecular weight of 2212 daltons and its sequence is: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. BPC-157 is also known as the “Wolverine” peptide, for its ability to help support repair and recovery, many have also found that it’s helped support gut issues, gastric reflux, depression, performance, and more.  BPC-157 has been studied for a variety of topics and has shown to be helpful in many areas such as: tendinopathy, gastric ulcers, general inflammation, and even neuroprotection. BPC-157 seems to work by interacting with our cells’ systems that are responsible for growth and repair, thus helping the body to heal itself. One of the most exciting potential benefits of BPC-157 is its ability to help with tendon repair. Tendons are the tough, fibrous tissues that connect our muscles to our bones and are essential for movement. However, tendons are also susceptible to injury and can often be slow to heal. This is where BPC-157 comes in; by aiding in the repair and regeneration of damaged tendons, BPC-157 could potentially help reduce recovery time and improve outcomes following an injury. BPC-157 has also been shown to be beneficial in supporting the healing of gastric ulcers. Gastric ulcers are a type of peptic ulcer that develops in the lining of the stomach. They are a common and often painful condition that can be difficult to treat. However, BPC-157 has been shown to promote healing of gastric ulcers and improve symptoms. There is also some evidence to suggest that BPC-157 may be helpful in supporting inflammatory bowel disease (IBD). IBD is a chronic condition that causes inflammation of the digestive tract. Symptoms can include abdominal pain, diarrhea, and weight loss. BPC-157 has been shown to reduce inflammation and improve symptoms in animal models of IBD. Overall, BPC-157 appears to be a promising compound with the potential to support a variety of gastrointestinal disorders.  One of the best things about BPC-157 is that it is orally bioavailable, particularly the arginate salt we use, is extremely stable.   We wanted to make sure that oral bioavailability was maximized which is why we included a molecule called SNAC in our formulation. Salcaprozate sodium, or SNAC, is one of the most advanced intestinal permeation enhancers that have been tested in clinical trials for oral delivery of macromolecules. It was originally designed for the oral delivery of insulin. In one study, SNAC increased the absorption of a peptide (a short chain of amino acids) by nine-fold without affecting tight junctions.  Healthgevity's formulation includes an optimal ratio of salcaprozate sodium to our active ingredients. This combination results in exceptional oral absorption of this combination without compromising its stability or efficacy. *This item may take longer to ship out* REFERENCES BPC-157: Staresinic M, Japjec M, Vranes H, Prtoric A, Zizek H, Krezic I, Gojkovic S, Smoday IM, Oroz K, Staresinic E, Dretar V, Yago H, Milavic M, Sikiric S, Lovric E, Batelja Vuletic L, Simeon P, Dobric I, Strbe S, Kokot A, Vlainic J, Blagaic AB, Skrtic A, Seiwerth S, Sikiric P. Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle. Biomedicines. 2022; 10(12):3221. https://doi.org/10.3390/biomedicines10123221 Seiwerth, Sven et al. “BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing.” Current pharmaceutical design vol. 24,18 (2018): 1972-1989. doi:10.2174/1381612824666180712110447 Gwyer, Daniel et al. “Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing.” Cell and tissue research vol. 377,2 (2019): 153-159. doi:10.1007/s00441-019-03016-8 Chang, Chung-Hsun et al. “The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.” Journal of applied physiology (Bethesda, Md. : 1985) vol. 110,3 (2011): 774-80. doi:10.1152/japplphysiol.00945.2010 Sikiric, Predrag et al. “Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications.” Current neuropharmacology vol. 14,8 (2016): 857-865. doi:10.2174/1570159x13666160502153022  Seiwerth, S., Sikiric, P., Grabarevic, Z., Zoricic, I., Hanzevacki, M., Ljubanovic, D., … Kolega, Z. (1997). BPC 157’s effect on Healing. Journal of Physiology Paris, 91(3–5), 173–178. https://doi.org/10.1016/S0928-4257(97)89480-6 Salcaprozate sodium (SNAC): Twarog, Caroline et al. “Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C10).” Pharmaceutics vol. 11,2 78. 13 Feb. 2019, doi:10.3390/pharmaceutics11020078 Zhu Q, Chen Z, Paul PK, Lu Y, Wu W, Qi J. Oral delivery of proteins and peptides: Challenges, status quo and future perspectives. Acta Pharm Sin B. 2021 Aug;11(8):2416-2448. doi: 10.1016/j.apsb.2021.04.001. Epub 2021 Apr 29. PMID: 34522593; PMCID: PMC8424290. Aroda, V.R., Blonde, L. & Pratley, R.E. A new era for oral peptides: SNAC and the development of oral semaglutide for the treatment of type 2 diabetes. Rev Endocr Metab Disord 23, 979–994 (2022). https://doi.org/10.1007/s11154-022-09735-8

BPC+PEA 500 is a synergistic blend of highly orally bio-available BPC-157 (Arginine Salt) with Palmitoylethanolamide (PEA) and added Salcaprozate sodium (SNAC) for enhanced absorption.  This is an ideal formula for anyone looking to support full body repair and regeneration. The peptide BPC-157 is a pentadecapeptide made up of 15 amino acids that is derived from human gastric juice. It has a molecular weight of 2212 daltons and its sequence is: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. BPC-157 is also known as the “Wolverine” peptide, for its ability to help support repair and recovery, many have also found that it’s helped support gut issues, gastric reflux, depression, performance, and more.  BPC-157 has been studied for a variety of topics and has shown to be helpful in many areas such as: tendinopathy, gastric ulcers, general inflammation, and even neuroprotection. BPC-157 seems to work by interacting with our cells’ systems that are responsible for growth and repair, thus helping the body to heal itself. One of the most exciting potential benefits of BPC-157 is its ability to help with tendon repair. Tendons are the tough, fibrous tissues that connect our muscles to our bones and are essential for movement. However, tendons are also susceptible to injury and can often be slow to heal. This is where BPC-157 comes in; by aiding in the repair and regeneration of damaged tendons, BPC-157 could potentially help reduce recovery time and improve outcomes following an injury. BPC-157 has also been shown to be beneficial in supporting the healing of gastric ulcers. Gastric ulcers are a type of peptic ulcer that develops in the lining of the stomach. They are a common and often painful condition that can be difficult to treat. However, BPC-157 has been shown to promote healing of gastric ulcers and improve symptoms. There is also some evidence to suggest that BPC-157 may be helpful in supporting inflammatory bowel disease (IBD). IBD is a chronic condition that causes inflammation of the digestive tract. Symptoms can include abdominal pain, diarrhea, and weight loss. BPC-157 has been shown to reduce inflammation and improve symptoms in animal models of IBD. Overall, BPC-157 appears to be a promising compound with the potential to support a variety of gastrointestinal disorders.  One of the best things about BPC-157 is that it is orally bioavailable, particularly the arginate salt we use, is extremely stable.   We wanted to make sure that oral bioavailability was maximized which is why we included a molecule called SNAC in our formulation. Salcaprozate sodium, or SNAC, is one of the most advanced intestinal permeation enhancers that have been tested in clinical trials for oral delivery of macromolecules. It was originally designed for the oral delivery of insulin. In one study, SNAC increased the absorption of a peptide (a short chain of amino acids) by nine-fold without affecting tight junctions.  Healthgevity's formulation includes an optimal ratio of salcaprozate sodium to our active ingredients. This combination results in exceptional oral absorption of this combination without compromising its stability or efficacy. Palmitoylethanolamide (PEA) is an 18-carbon long- chain fatty acid. Nobel Prize winner Levi-Montalcini identified PEA as a naturally occurring molecule, describing its value in treating chronic infections and pain. Following her discovery, hundreds of scientific studies have been published to show that it is very effective and safe to use. PEA is thought to work by supporting the inflammatory response through the PPAR-a receptor, COX-2 and through effects on NF-kappaB signaling while also by restoring balance in the endocannabinoid system. Its mechanism of action is similar to that of non-steroidal anti-inflammatory drugs (NSAIDs). Palmitoylethanolamide (PEA) is the body’s go-to- molecule and is made on demand when required under disease conditions.  This naturally occurs to help resolve inflammation and pain to restore the body to a normal, health state. Due to its ubiquitous nature and presence in all cells, PEA has wide-ranging therapeutic applications. Some of the most common clinical applications are analgesic effects, chronic pain, and inflammation support. PEA has anti-inflammatory effects on the body by inhibiting the production of pro-inflammatory cytokines and by reducing the activity of activated microglia cells. It is also thought to reduce pain by modulating the neurotransmitters involved in pain signaling. In addition to its analgesic and anti-inflammatory effects, PEA is also thought to offer neuroprotection by reducing the levels of reactive oxygen species and by modulating cell death pathways. It has also been shown to improve cognitive function in animal models of Alzheimer's disease. The endocannabinoid system is involved in a wide range of physiological processes, including digestion. The role of the endocannabinoid system in the gut has been studied extensively and it is now well-established that cannabinoids modulate gastrointestinal motility, secretion and inflammation. PEA is one of the most abundant endocannabinoids in the gut and is thought to play a key role in gut-brain axis. The endocannabinoid system is known to be involved in various digestive disorders, such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD). Several studies have shown that PEA is effective in reducing symptoms of IBS, such as abdominal pain and bloating. A recent clinical trial showed that a PEA-based product was able to significantly reduce IBS symptoms in patients who did not respond to standard therapy. PEA has also been shown to be effective in supporting other digestive disorders such as GERD and IBD. In a clinical trial, PEA was able to significantly reduce symptoms of GERD, such as heartburn and acid reflux. *This item may take longer to ship out*

Discover the power of BPC-157,  KPV (Lysine-Proline-Valine) and Palmitoylethanolamide (PEA) in our advanced formulation, enriched with salcaprozate sodium (SNAC) for superior absorption. BPC-157 has been studied for a variety of topics and has shown to be helpful in many areas such as: tendinopathy, gastric ulcers, general inflammation, and even neuroprotection. BPC-157 seems to work by interacting with our cells’ systems that are responsible for growth and repair, thus helping the body to heal itself. One of the best things about BPC-157 is that it is orally bioavailable, particularly the arginate salt we use, is extremely stable.   We wanted to make sure that oral bioavailability was maximized which is why we included a molecule called SNAC in our formulation.  KPV stands out for its remarkable anti-inflammatory support potential. Consisting of lysine, proline, and valine, has shown significant promise in modulating the body's inflammatory responses, making it a subject of great interest in medical research. KPV has become a focal point for researchers due to its diverse supportive health benefits. Its anti-inflammatory supportive properties are particularly noteworthy in the context of chronic inflammatory conditions, such as inflammatory bowel disease (IBD), arthritis, and various skin disorders. Studies have demonstrated that KPV can support inflammation by modulating the production of pro-inflammatory cytokines and modulating immune cell activity.  Palmitoylethanolamide (PEA) is an 18-carbon long- chain fatty acid. Nobel Prize winner Levi-Montalcini identified PEA as a naturally occurring molecule, describing its value in treating chronic infections and pain. Following her discovery, hundreds of scientific studies have been published to show that it is very effective and safe to use. PEA is thought to work by supporting the inflammatory response through the PPAR-a receptor, COX-2 and through effects on NF-kappaB signaling while also by restoring balance in the endocannabinoid system. Its mechanism of action is similar to that of non-steroidal anti-inflammatory drugs (NSAIDs). Palmitoylethanolamide (PEA) is the body’s go-to- molecule and is made on demand when required under disease conditions.  This naturally occurs to help resolve inflammation and pain to restore the body to a normal, health state. Due to its ubiquitous nature and presence in all cells, PEA has wide-ranging therapeutic applications. Some of the most common clinical applications are analgesic effects, chronic pain, and inflammation support. PEA has anti-inflammatory effects on the body by inhibiting the production of pro-inflammatory cytokines and by reducing the activity of activated microglia cells. It is also thought to reduce pain by modulating the neurotransmitters involved in pain signaling. In addition to its analgesic and anti-inflammatory effects, PEA is also thought to offer neuroprotection by reducing the levels of reactive oxygen species and by modulating cell death pathways. It has also been shown to improve cognitive function in animal models of Alzheimer's disease. The endocannabinoid system is involved in a wide range of physiological processes, including digestion. The role of the endocannabinoid system in the gut has been studied extensively and it is now well-established that cannabinoids modulate gastrointestinal motility, secretion and inflammation. PEA is one of the most abundant endocannabinoids in the gut and is thought to play a key role in gut-brain axis. The endocannabinoid system is known to be involved in various digestive disorders, such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD). Several studies have shown that PEA is effective in reducing symptoms of IBS, such as abdominal pain and bloating. A recent clinical trial showed that a PEA-based product was able to significantly reduce IBS symptoms in patients who did not respond to standard therapy. PEA has also been shown to be effective in supporting other digestive disorders such as GERD and IBD. In a clinical trial, PEA was able to significantly reduce symptoms of GERD, such as heartburn and acid reflux. The synergy of BPC, KPV and PEA,  offers a comprehensive approach often used to support inflammation, gut health, and conditions such as Inflammatory Bowel Disease (IBD). PEA's documented anti-inflammatory, analgesic, antimicrobial, immunomodulatory, and neuroprotective effects make it a versatile ingredient with broad therapeutic applications. Salcaprozate sodium, or SNAC, is one of the most advanced intestinal permeation enhancers that have been tested in clinical trials for oral delivery of macromolecules. It was originally designed for the oral delivery of insulin. In one study, SNAC increased the absorption of a peptide (a short chain of amino acids) by nine-fold without affecting tight junctions.  Healthgevity's formulation includes an optimal ratio of salcaprozate sodium to our active ingredients. This combination results in exceptional oral absorption of this combination without compromising its stability or efficacy. *This item may take longer to ship out*

Brain Boost+ is a powerful combination of paraxanthine, alpha-GPC, lion’s mane, N-acetyl L-tyrosine (NALT) and L-Theanine help to increase energy levels, cognitive function, motivation, and focus all while reducing fatigue. Brain Boost+ may also aid in the prevention of age-related cognitive decline and has neuroprotective properties without the jitters or crash.  The ingredients included in Brain Boost+ have shown positive changes in brain wave activity specifically delta and theta waves which are associated with focus and decision making under pressure, making it the ideal formula to utilize when needing a desired edge.  Paraxanthine (enfinity®) is caffeine’s primary metabolite in the human body, contributing to the vast majority of caffeine’s beneficial effects. It is a central nervous system stimulant without the toxicity associated with caffeine and has shown greater benefits than caffeine itself. Caffeine has numerous issues with the gene (CYP1A2, caffeine metabolizer gene), where some are slow metabolizers and deal with much of the side effects and fast metabolizers get little of the benefits.  Only about 30% are ideal metabolizers of caffeine leading to much diversity in how it is experienced. When ingested, enfinity® functions more consistently than caffeine, leading to fewer side effects, greater enjoyability, improved mood, and a more focused mindset.  Multiple studies have shown those benefits to include:  Energy, focus, and wakeful clarity. Enhanced mood and sense of wellbeing. Neuroprotective cognitive accelerant. Improved reaction time and reduced mental errors. Increased caloric expenditure and thermogenesis. Significantly lessened side effects of caffeine with dramatically reduced toxicity. More consistent results: eliminates caffeine’s genetic variability, reducing crashes and anxiety. Alpha-GPC or Alpha-Glycerophoscholine, is a natural compound found in the brain that also exists in small amounts in certain foods.  It’s known for its potential cognitive enhancement and physical performance properties. GeniusPure®Alpha-GPC is a new breakthrough version, 90% yield that is engineered to be hygroscopically stable. Various studies show alpha-GPC supports cognitive function, memory and learning.  Alpha-GPC is a precursor to acetylcholine, a neurotransmitter critical for brain health and crosses the blood-brain barrier.  Lion’s Mane (Hericium erinaceus) is a type of mushroom that has been used in traditional medicine for its potential health benefits especially for the brain.  Lion’s Mane contains compounds that may stimulate the production of nerve growth factor (NGF) in the brain.  NGF is involved in the growth, maintenance, and survival of neurons.  By promoting NGF production, Lion’s Mane may support brain health and cognitive function. N-acetyl L-tyrosine (NALT) is a modified form of the amino acid L-tyrosine.  Tyrosine is a precursor to several important neurotransmitters, including dopamine, norepinephrine, and epinephrine.  These neurotransmitters play key roles in mood regulation, focus, attention, stress support and cognitive function. L-Theanine is an amino acid known for its calming effects and potential benefits for relaxation, focus and cognitive function.   It is known to have a synergistic effect when paired with paraxanthine promoting alertness and focus without the jittery side effects often associated with caffeine use. L-Theanine can cross the blood-brain barrier and affect various neurotransmitters in the brain such as GABA, serotonin and dopamine. It is also known to increase alpha brain wave activity which is associated with a relaxed but alert mental state. *This item may take longer to ship out* 

Enhancing vascular health and addressing the challenges of aging represent critical healthcare priorities worldwide. The foundation of healthy aging hinges upon maintaining robust arterial function and a strong, resilient heart. Introducing Cardio NAD+ 2.0: an advanced solution crafted with cutting-edge ingredients aimed at optimizing cardiovascular well-being. Meticulously formulated to synergistically target various aspects of heart health, this groundbreaking blend underscores the crucial interplay between NAD+ and cardiac vitality, showcasing potent cardioprotective effects. Featured Supportive Benefits:  Improves net NAD+ status by supporting both its synthesis and limiting its degradation  Supports healthy blood pressure  Improves vascular aging, endothelial function and glycocalyx health Supports healthy fibrinolytic activity and clotting function Promotes healthy circulation and blood flow  Inhibits platelet & red blood cell aggregation Decreases blood viscosity Supports clinical measures of inflammation  Supports healthy levels of nitric oxide Inhibits lipid peroxidation Supports healthy lipid metabolism Demonstrated reduction in various independent cardiovascular risk factors *This item may take longer to ship out* NAD3® + Niacinamide: The first ingredient selected is NAD3®, a new and novel ingredient which uses a different approach to manage cardiovascular factors while having positive influences on the hallmarks of aging.  NAD3® is a unique blend of Wasabi japonica extract, theacrine and copper(I)-niacin complex. It turbocharges enzymes that boost the conversion of NAD+ precursors to NAD+ while also suppressing the activity proteins that deplete NAD+. This product has been designed to help modulate inflammation and reduce lipids in our blood associated with heart disease. Compared to placebo, at a dose of 312mg daily, NAD3® lead to significant changes in multiple cardiovascular risk factors (-19%VLDL, -16%LDL, -12%Tot Chol) with a safe, well-tolerated dietary supplement that also demonstrated multiple additional benefits related to healthy aging and cellular longevity.  NAD3® may improve NAD+ status by supporting its synthesis and limiting its degradation, in addition to activating the downstream signaling pathways of longevity, while minimizing the chronic stress of aging. NAD3® slows down biological aging by playing both “offense” (amplifying the stress-resilience/ longevity genes), and “defense” (by mitigating the molecular and biochemical hallmarks of aging).  A recent published study demonstrated NAD3® can positively alter molecular markers related to lipid metabolism, cardiometabolic health and hallmarks of aging. NAD3® is a multi-mechanistic solution for healthy aging, mitochondrial performance, cellular longevity. In addition, we have added 200mg’s of niacinamide per serving. A single dose of 200 mg niacinamide has been shown to be sufficient to target NAD+ salvage and other metabolic pathways to affect blood metabolites.These findings demonstrate the feasibility of niacinamide supplementation to modulate metabolic pathways in humans, especially since niacinamide has been studied as a dietary supplement for decades and excellent safety data on long-term use are already available. PeptiPump™ Peptide Complex: Healthgevity has also partnered with Nuritas to harness their proprietary technology, which evaluates millions of plant proteins. This innovative approach sifts through vast molecular data to forecast natural plant bioactive peptides, identifying which have the most Angiotensin-converting enzyme inhibition (ACEi) activity. Leveraging state-of-the-art AI-driven precision technology, Nuritas uncovered groundbreaking peptides known as PeptiPump™. Derived from lentil protein hydrolysate, PeptiPump™ boasts a network of patented bioactive peptides, meticulously designed to withstand gastrointestinal digestion. Studies have demonstrated that ACE inhibition not only enhances muscle oxygenation but also promotes improved blood flow within skeletal muscles. Coenzyme Q10 (CoQ10): CoQ10 is renowned for its myriad health benefits, encompassing support for heart health, cognitive function, and muscular vitality. Its potent antioxidative properties combat oxidative stress, enhance energy production, and contribute to supporting healthy blood pressure and cholesterol levels. By shielding cells from oxidative damage, CoQ10 holds promise in mitigating the risk of chronic ailments. Crucially, CoQ10 plays a pivotal role in cellular energy production, rendering it a compelling natural remedy for combatting fatigue and muscle weakness. Cardio NAD+ features a novel ingredient newly introduced to the US market, featuring CoQ10 enhanced by LEO-HB® technology. This eco-friendly, cutting-edge solid-solid technology transforms poorly soluble, bioactive ingredients with limited bioavailability into highly efficient, free-flowing powders. These powders seamlessly disperse in cold water, ensuring rapid solubility and superior performance. Fucoidan: Mekabu extract, sourced from Undaria pinnatifida, commonly known as wakame, is specifically derived from the sporophyll, the reproductive structure of this brown seaweed. This extract is standardized to contain approximately 85% fucoidan, a complex carbohydrate abundantly present in various brown seaweeds. Fucoidan has garnered considerable attention in the realm of nutrition and health, particularly for its potential cardiovascular benefits. The glycocalyx, a layer of intricate carbohydrates enveloping endothelial cells along blood vessel walls, plays a pivotal role in vascular function. Dysfunction or damage to the glycocalyx is closely linked to cardiovascular diseases like atherosclerosis and hypertension. Research indicates that fucoidan exhibits remarkable properties in glycocalyx regeneration. By fostering the repair and rejuvenation of the glycocalyx, fucoidan aids in preserving endothelial integrity and functionality. Consequently, this supports enhanced vascular health and potentially mitigates the risk of cardiovascular complications. FitNox®: FitNox® is a cutting-edge formulation featuring three potent botanical extracts (moringa, pomegranate and black ginger) meticulously chosen to amplify vasodilation and endurance by naturally boosting nitric oxide (NO) levels within the body, without relying on nitrates. Harnessing the power of Polar-Nonpolar-Sandwich (PNS) technology, these botanical components are encapsulated within a protective plant-based matrix for optimal delivery. Scientific studies have demonstrated that FitNox® significantly elevates nitric oxide (NO) levels by up to 336%, facilitating enhanced vasodilation and blood flow. It targets various components involved in NO production, thereby supporting improved endurance while counteracting factors that induce fatigue and limit performance. Moreover, short-term supplementation with FitNox® yields rapid and sustained increases in Nitrate and Nitrite levels, with effects manifesting within just one hour and lasting up to ten hours. This swift and enduring response underscores its capacity to promptly elevate nitric oxide levels, fostering improved pump and blood flow for enhanced performance.A long term (22 day) study was performed to investigate the efficacy of oral intake of 250 mg of FitNox® on physical endurance in healthy male adults before and after exercise. Measurements were taken in regard to nitrate and nitrite (PK), Lactate dehydrogenase (LDH), Malondialdehyde (MDA), dopamine and exercise efficiency. Nattokinase: We've meticulously crafted ingredient combinations to address critical facets of heart health, including blood pressure regulation and blood viscosity management. Cardio NAD+ features nattokinase, renowned for its ability to promote healthy inflammation levels, mitigate clot formation, and optimize blood pressure, supported by extensive research spanning numerous years. Derived from soybeans, this natural ingredient has demonstrated remarkable efficacy, with studies showcasing a reduction in systolic blood pressure by 13.55 points in just four weeks. In vitro experiments and human trials further highlight nattokinase's potential to enhance blood flow, decrease blood viscosity, diminish red blood cell stickiness, and inhibit platelet aggregation. Bergamot: Citrus Bergamot, an aromatic fruit from southern Italy, has also been added to the formula.  Bergamot's remarkable properties have been extensively studied, revealing its ability to positively impact various cardio-metabolic biomarkers, including cholesterol, triglycerides, LDL, and HDL. This unique blend of natural ingredients offers unparalleled supportive protection against one of the leading global causes of mortality. By fortifying lipid profiles, optimizing blood pressure, and addressing systemic inflammation, this formulation enhances cardiovascular mechanics and offers multifaceted benefits for overall heart health and well-being. If you have a known sensitivity to niacin, we recommend starting with one capsule to assess your tolerance before gradually increasing to the full dose. Consult your healthcare provider for personalized guidance on the best way to incorporate this supplement into your routine.

DailyDIM+™ was created in collaboration with leading bioidentical hormone providers and is a scientifically formulated supplement designed to support optimal estrogen metabolism and detoxification in both men and women. With a synergistic blend of bioactive ingredients, DailyDIM+™ promotes hormone balance, cellular health, and antioxidant protection support. Key Benefits: Supports Estrogen Balance – Helps maintain a healthy estrogen ratio to promote hormonal harmony. Enhances Estrogen Detoxification – Supports liver pathways for proper estrogen metabolism and excretion support. Encourages Cellular Antioxidant Defense – Protects DNA stability and may reduce oxidative stress. Optimized Absorption & Bioavailability – Includes AstraGin® and Ioniplex® for enhanced nutrient uptake. Ingredient Overview:  DIM (Diindolylmethane) Diindolylmethane (DIM) is a bioactive compound derived from cruciferous vegetables that supports hormonal balance, estrogen metabolism, and cellular health. Research shows DIM promotes the conversion of estrogen into protective metabolites while reducing harmful forms, benefiting both men and women. It may also act as a natural aromatase inhibitor, supporting a healthy testosterone-to-estrogen ratio in men. Additionally, DIM enhances liver detoxification, reduces oxidative stress through NRF2 activation, and exhibits anti-inflammatory properties. Studies suggest DIM plays a role in breast and prostate health.  Its ability to modulate hormone levels, support detox pathways, and provide antioxidant protection makes it a valuable supplement for overall wellness. Calcium-D-Glucarate Calcium-D-Glucarate is a calcium salt of D-glucaric acid, a naturally occurring compound found in fruits and vegetables that supports detoxification and hormone balance. It works by inhibiting beta-glucuronidase, an enzyme that can reabsorb toxins and excess estrogen in the gut, thereby promoting their excretion through phase II liver detox pathways. This helps maintain healthy estrogen metabolism, reducing estrogen dominance and supporting conditions like PMS, PCOS, and hormone-related imbalances. Additionally, Calcium-D-Glucarate aids in the elimination of carcinogens and environmental toxins, making it beneficial for liver health, cellular protection, and overall detoxification. Activated BroccoRaphanin™ Activated BroccoRaphanin™ (Broccoli Seed Extract + Myrosinase Enzyme) is a broccoli seed extract enhanced with myrosinase enzyme, designed to optimize the production of sulforaphane, a powerful bioactive compound known for its detoxification, antioxidant, and anti-inflammatory properties. Sulforaphane activates the NRF2 pathway, which boosts the body's natural defense system against oxidative stress and supports cellular detoxification. It enhances liver function, promotes the elimination of toxins and excess hormones, and has been shown to support estrogen metabolism and hormone balance. Additionally, sulforaphane has neuroprotective and cardioprotective benefits, supports a healthy inflammatory response, and has been widely studied for its potential role in immune health. Ioniplex® (Fulvic Ionic Mineral Complex) Ioniplex® is a natural fulvic ionic mineral complex designed to enhance nutrient absorption and cellular energy production. By facilitating the transport of essential nutrients into cells while aiding in the removal of waste, it supports the body’s natural detoxification processes. Clinically tested, Ioniplex® has been shown to improve mitochondrial function, optimize glucose metabolism, and promote effective detoxification, making it a powerful component for overall health and vitality. AstraGin® (Astragalus membranaceus and Panax notoginseng)  AstraGin®, a proprietary blend of root extracts from Astragalus membranaceus and Panax notoginseng,  contain key bioactive compounds, astragaloside I, IV, and ginsenoside Rb1, which are known to play a significant role in supporting hormone optimization by enhancing nutrient absorption, modulating estrogen activity, regulating stress hormones, and promoting cellular resilience. This Patented blend that enhances bioavailability of nutrients, including DIM and calcium-D-glucarate.  AstraGin® also been shown to support gut health and optimize nutrient transport across the intestinal barrier in over 20 studies supporting these capabilities. *This item may take longer to ship out*

Ignite+ is an exclusive breakthrough formula combining the leading ingredients available to increase metabolism, improve insulin signaling, body composition, reduce uptake of glucose into our bodies, and so much more. One of the best ways to prevent insulin resistance is to help remove excess glucose from our blood. We are the first to pair these several effective glucose disposal agents together to target several vital pathways that regulate metabolic efficiency. Ignite+ is an advanced metabolic optimization formula whose ingredients have been shown to support: Reduction of adiposity and visceral fat* Increase thermogenesis by raising the metabolic rate and calorie burning* Browning of white adipose tissue* Diet-induced weight gain* Increase fatty acid oxidation* Ramp up ketone levels* Improves glucose tolerance and glucose control* AMPK activation* Leptin and ghrelin levels* Regulation of a healthy metabolism and mitochondrial health* WHAT MAKES IGNITE+ SO IMPACTFUL? First, we have included InnoSlim®, a proprietary blend of purified, fractionated extracts of Panax notoginseng and Astragalus root produced by a pharmaceutical-grade extraction technology which delivers astragalosides and ginsenosides Rg1 and Rb1. Research has shown it supports the production of adiponectin, a protein hormone that helps modulate metabolic processes such as glucose regulation and fatty acid metabolism. InnoSlim® reduces glucose absorption in the intestine by 42%. This means that only 58% of the glucose you eat will be absorbed in your intestine. In addition, InnoSlim® also increases glucose absorption in muscle and fat cells by 50% and 68% by upregulating GLUT4 transporters, which takes glucose from our blood and transfers it into the muscle tissue. InnoSlim® has also been shown to support appetite control, AMPK activation, insulin resistance, triglycerides and sdLDL in cell, animal and human studies. One other mechanism Ignite targets to improve our metabolic health and weight is to increase the energy expenditure of our bodies. Ignite delivers several ingredients in the formula which help our bodies do this process. Each of these has unique mechanisms of action but combine to make massive differences in the energy we use and how we process glucose in our bloodstream. MitoBurn® (L-BAIBA): Mitoburn® is an exercise mimetic, which mimics exercise’s effect on our tissues. This signals the body to help reduce fatty acids in our system, which are another energy source other than glucose. It can also help produce ketones which reduce appetite and improve energy output. It has also been shown to: Assist in the browning of white fat, activating AMPK, increasing metabolic rate, supporting leptin levels, and insulin resistance. GlucoVantage® Dihydroberberine: Dihydroberberine is a new version of traditional berberine that is up to 5x more bioavailable/absorbable and 2x longer lasting (8 hours vs. 4 hours). In one study, this led to 25.9% reduced blood glucose levels compared to the start of the trial in many patients. Dihydroberberine can also help with advanced glycation end products correlated with aging while supporting blood glucose disposal and improving insulin sensitivity and body composition. Factor21® (Bitter Melon Extract): Factor21® is a natural regulator of a hormone growth factor called Fibroblast Growth Factor 21 (FGF21) and is an AMPK activator. FGF21 is a potent longevity factor coordinating interactions between energy metabolism and stress responses. Recent studies have revealed that supporting FGF21 can alleviate many age-related metabolic disorders. Factor21® is also an exercise mimetic that has many actions, including improved insulin secretion to drive glucose out of the bloodstream and inhibit fat cell growth. DNF-10 satiety peptide complex is obtained from a screening of small molecular weight peptides (<10 kDa) after proteolysis of Saccharomyces cerevisiae, a non-pathogenic yeast. The peptides from DNF-10 lower the hypothalamic expression of neuropeptide Y and downregulate ghrelin, thereby reducing the physiological hunger cues confirmed in multiple published studies. CalorieBurn GP® Grains of Paradise seed extract (6-Paradol 12.5%): CalorieBurn® contains bioactive compounds 6-paradol, 6-shogaol, 6-gingerol, and 6- gingerdione. These have been shown to effectively trigger highly thermogenic Brown Adipose Tissue (BAT) when taken in a precise ratio to one another, resulting in a 5X increase in calories burned over 2 hours compared to placebo. On average, burned 97 kcal more calories daily and lost more visceral fat. In another study, 40mg results in a 400% increase in metabolic rate within 30 minutes. Administration of this also reverses the unbalanced gut microbiota composition induced by a high-fat diet with a decrease in Firmicutes / Bacteroidetes ratio and increase in general Bifidobacterium and Akkermansia. Actiponin® (gynostemma pentaphyllum extract): Actiponin® is a patented, clinically backed, natural fat loss ingredient derived from gynostemma pentaphyllum. The patented technology featured in Actiponin® makes it 10 times more potent than traditional gynostemma pentaphyllum extracts. The fundamental mechanism of Actiponin® is the activation of 5′ AMP-activated protein kinase (AMPK) which is typically activated by exercise and plays a crucial role in metabolic health by regulating fat-burning along with energy production.During 12 weeks of Actiponin® supplementation, total abdominal fat area, body weight, body fat mass, percent body fat, and BMI were significantly decreased. In this same study, waist circumference decreased on average 2.90 cm (1.1 inches) over 3 months. Another recent study showed that 88% of Americans were metabolically unhealthy. Metabolic resistance is a concern for everyone as they try to improve their physical appearance and overall health. Ignite is a unique combination of clinically verified ingredients built to help optimize metabolic health and weight control. Together, these ingredients synergize to reduce the factors which lead to weight gain and insulin sensitivity to create the best metabolic control formulation on the market. *This item may take longer to ship out*

Featured Benefits:  Optimizes iron levels fueling cellular energy and oxygen to the muscles Supports a healthy immune system Promotes a healthy gut function Balances  a healthy microbiome Modulates a healthy inflammatory response Maintains iron homeostasis Supports respiratory health From birth to old age, the human body constantly faces harmful factors that disrupt its natural balance, damage the genome, trigger cell death, and lead to degeneration, which can result in various diseases. These disruptions, caused by pathogens, viruses, gene dysregulation, and immune system disorders, challenge our health daily. However, lactoferrin, often dubbed a "miracle molecule," has emerged as a potent protective agent. This powerful protein boasts antimicrobial, antiviral, antioxidant, and immune-stimulating properties while also binding to DNA, offering a robust defense against these harmful forces. We are thrilled to be partnering with Helaina, a cutting-edge biotechnology company that uses precision fermentation to recreate human proteins found in colostrum, launching a new category of adaptive nutrients. Helaina's replicated human bioactive compounds precisely mirror their natural counterparts, ensuring optimal bioavailability, superior absorption, purity, and effectiveness. Over the past few years, a team of over 35 scientists collaborated to develop their flagship innovation: effera™, the world’s first human-identical lactoferrin. Effera™ is designed to support balanced iron metabolism, enhance immune function, and promote optimal health and vitality. Backed by 49 patents, 2 clinical studies, and 5 preclinical studies, effera™ stands as a groundbreaking advancement in nutrition. This includes a 2024 human safety study that showed no antibody production against effera™, confirming the body recognizes it as its own and not as a foreign protein.  The protein also breaks down into the same beneficial peptides as naturally occurring human lactoferrin.  Human lactoferrin, the most abundant protein in human colostrum, also naturally occurs in saliva, sweat, and tears, playing a vital role in optimizing iron levels and promoting balanced iron utilization and homeostasis. With its innate intelligence, human lactoferrin identifies and buffers areas with excess iron, making it essential for active lifestyles and women's health during life stages such as menstruation, pregnancy, menopause, and lactation. Effera™ leverages these iron-regulating properties to promote a healthy immune and inflammatory response, foster gut health by stimulating beneficial bacteria like bifidobacteria, and help maintain a balanced microbiome for overall well-being. IMMUSE® is a unique, patented strain of lactic acid bacteria (microorganisms commonly used in food fermentation) scientifically known as Lactococcus lactis strain Plasma (or LC-Plasma) that stimulates multiple types of immune cells for more comprehensive immune support in a single ingredient. However, it’s not a probiotic like most lactic acid bacteria. IMMUSE® is a postbiotic,  an exciting new category of biotics shown to provide health benefits to the body. In this case, an added level of protection and revolutionary immunity support thanks to LC-Plasma’s novel mechanism of action. Backed by 30 published studies, including 15 human trials, IMMUSE® has been clinically shown to safely stimulate immune function at the cellular level for more dynamic and robust responses — preparing your body’s natural defense system to protect your physical health. LC-Plasma is the first bacteria strain clinically shown to activate a rare type of immune cell called pDC (plasmacytoid dendritic cell), an important leader of the immune system. Once activated, pDCs signal the stimulation of other key immune cells involved in the innate and adaptive immune responses. Clinical research shows that IMMUSE's novel mechanism of action helps get multiple immune cell types ready to perform their specialized roles, providing comprehensive immune support without overstimulating the immune system. 2′-O-fucosyllactose (2′-FL) is the most abundant human milk oligosaccharide (HMO), a type of complex sugar naturally found in human breast milk. HMO's are commonly associated with infant nutrition. However, emerging research highlights its potential health benefits for adults, particularly in supporting gut health, immunity, and reducing inflammation HMOs, including 2′-FL, work through four key mechanisms: Immunomodulation and Pathogen Protection Microbiome Homeostasis Gut Barrier Maturation and Function Gut-Brain Axis Support Here’s how 2′-FL can play a pivotal role in optimizing adult health: 1. Supports Gut Health 2′-FL acts as a prebiotic, stimulating the growth of beneficial gut bacteria, such as Bifidobacteria. This supports a healthy microbiome, which is crucial for digestion, nutrient absorption, and immune function. 2. Enhances Immune Function 2′-FL enhances immune function by acting as a decoy for harmful pathogens, including bacteria and viruses, preventing them from binding to intestinal cells and triggering infections. This function is particularly beneficial for adults, as it strengthens immune defenses, lowers the incidence of gastrointestinal infections, and contributes to overall immune resilience—especially important as the immune system naturally declines with age. *This item may take longer to ship out*

  Discover the power of KPV (Lysine-Proline-Valine) and Palmitoylethanolamide (PEA) in our advanced formulation, enriched with Salcaprozate sodium (SNAC) for superior absorption.   The synergy of KPV with PEA, an endocannabinoid-like lipid mediator, offers a comprehensive approach often used to support inflammation, and gut health. PEA's documented anti-inflammatory, analgesic, antimicrobial, immunomodulatory, and neuroprotective effects make it a versatile ingredient with broad therapeutic applications.  Notably, our formulation incorporates SNAC, a cutting-edge intestinal permeation enhancer tested in clinical trials for oral macromolecule delivery. In a groundbreaking study, SNAC demonstrated a remarkable nine-fold increase in amino acid absorption without impacting tight junctions. This innovation underscores our commitment to maximizing the bioavailability of KPV and PEA for optimal effectiveness. *This item may take longer to ship out*

  Biological aging is directly impacted by physiological integrity. Muscle strength, mass, function, quantity, and quality loss are some of the main issues associated with the process of aging. As we age the performance of our muscle cells decline which leads to a weakened immune system, sarcopenia, obesity, and chronic disease among much more. Healthgevity has selected PeptiStrong®, Senactiv®, PeptiPump® and AstraGin® which are all clinically proven ingredients to put your muscles in the best position to thrive regardless of your age. In a recent study it was concluded that lower muscle strength in late adolescence showed direct connection with higher risk of chronic disease. As such, skeletal muscle might be the central integrator between sarcopenia, obesity, immune senescence and more in an aging biological system. Preserving muscle mass is critical for optimizing health span.  Research shows the strongest one-third of the population over the age of 60 has a 50% lower death rate than the weakest, making muscle a key predictor of longevity.  Recent discoveries of clinically proven ‘growth promoting’ ingredients have made the process of building and preserving muscle more obtainable.  PeptiStrong®, Senactiv®, PeptiPump®  and AstraGin® work synergistically to target multiple mechanisms, to provide a wide range of benefits in muscle health.  PeptiStrong® (Peptides from hydrolyzed fava bean protein)  Through cutting edge Al-precision technology, Nuritas is creating a brand-new category of precision peptide ingredients from nature. Their cell-signaling power helps the body function at its best. Longevity is the first product resulting from Healthgevity's collaboration with Nuritas and contains PeptiStrong® : precision peptides that have been clinically proven to support muscle health. PeptiStrong® can increase muscle synthesis by supporting mTOR, reduce muscle loss by downregulating muscle atrophy related genes and improve muscle health by reducing inflammation properties. Backed by two peer-reviewed clinical studies, this plant-based intelligent ingredient has outperformed animal protein. It has a multi-dimensional effect on muscle health: promoting muscle strength, improving recovery after intense exercise, boosting energy,and supporting the synthesis of protein that assists in maintaining and building muscle. A 'peptide-specific’ effect to address the muscle homeostasis between muscle protein synthesis, muscle atrophy and inflammation, offers an alternative to a purely uncharacterized nutritional intervention.  In the most recent double blind placebo clinical study,  PeptiStrong®  alone provided:   Featured PeptiStrong® research benefits:  Regenerates muscles by increasing the expression of new muscle fibers. Type I “Slow Twitch” Muscle Fibers are responsible for endurance and strength endurance. They contain a higher number of mitochondria and utilize fat for energy. Type II “Fast Twitch” Muscle fibers are responsible for strength and forceproduction. Loss of Type II fibers is most associated with aging. Reduces muscle loss and fat accumulation Reduces Tumor Necrosis Factor-alpha (TNF-α) Improves cellular metabolism through the activation of AMPK which in turn increases the levels of NAD+ and sirtuins Maintains autophagy in skeletal muscle similar to fasting Induces mitochondrial biogenesis in the muscle cell   Senactiv® (Panax notoginseng (root) and Rosa roxburghii (fruit)) extracts containing ginsenoside Rg1 (new: dose doubled to 100mg) Senactiv® has over 10 years of research behind it including 2 in vivo studies and 5 human clinical trials.  A recent study confirmed a process to reverse aging in muscle cells. Aging in muscle cells is a function of a cell itself, not being able to divide and repair itself. The process is known as cellular senescence, and it happens during aging. This study found that by the overexpression of a particular protein called NANOG, the cell does not have be reset to a different state to reverse aging. Ginsenoside Rg1 contained in Senactiv®, has the potential to activate expression of NANOG to help in reversing the aging process in skeletal muscle.  A new mechanism of aging has been uncovered by researchers: the accumulation of sphingolipids. Ceramides, a widely known class of sphingolipids, build up in aging muscle and reduce its function, impacting the functional capacity of older adults.   Senactiv® has the potential to inhibit sphingolipid synthesis prevent age-related decline in muscle mass and reduce its function.   Senactiv® has been also shown to have the potential to:  Increase endurance performance endurance performance was extended by increasing energy in cells and increasing glycogen replenishment in muscles Speed up muscle fatigue recovery speeding up muscle fatigue recovery can be achieved by decreasing muscle inflammation during exercise and accelerating muscle inflammation recovery after exercise Muscle regeneration  muscle regeneration was increased by eliminating senescent cells and increasing new muscle growth PeptiPump® Peptide Complex: Healthgevity has tapped into new technology discovered by Nuritas to harness their proprietary technology, which evaluates millions of plant proteins. This innovative approach sifts through vast molecular data to forecast natural plant bioactive peptides, identifying which have the most Angiotensin-converting enzyme inhibition (ACEi) activity. Leveraging state-of-the-art AI-driven precision technology, Nuritas uncovered groundbreaking peptides known as PeptiPump™. Derived from lentil protein hydrolysate, PeptiPump™ boasts a network of patented bioactive peptides, meticulously designed to withstand gastrointestinal digestion. Studies have demonstrated that ACE inhibition not only enhances muscle oxygenation but also promotes improved blood flow within skeletal muscles. AstraGin® (Astragalus membranaceus and Panax notoginseng) root extracts containing astragaloside I, II, IV and ginsenoside Rb1: AstraGin® has been shown to increase intestinal arginine and leucine absorption by 67% and 58%, respectively, which contributes to the activation of the mTOR pathway and suggest increasing the skeletal muscle protein synthesis by up to 30%.  Recent studies show that the gut-muscle axis is a physiological target for combatting anabolic resistance and reducing risk of sarcopenia. AstraGin® has shown in 16 in-vitro and 8 in-vivo studies that are published in the Journal of Agricultural and Food Chemistry, Molecular Nutrition & Food Research and Scientific Reports to:  Increase the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up regulating the absorption specific mRNA and transporters, such as SGLT1, CAT1, and GLUT4.  Repair ulcerated and damaged intestinal walls and reduce intestinal submucosa inflammation. AstraGin® was shown in a hematoxylin-eosin stain and a MPO assay to reduce ulceration and unclear surfaces of intestinal epithelial cells and sub-mucosal edema in TNBS- induced colitis rats.  May help maintain a healthy microbiota population by mending ulcerated and damaged intestinal epithelial cell surfaces for the microbiota to populate.  May help support stronger immune functions by mending ulcerated epithelial cells and reducing the inflammation in intestinal mucosal lamina propria that hosts the gut- associated lymphoid tissue (GALT1), T cells, plasma cells, mast cells, dendritic cells, and macrophages.  *This item may take longer to ship out*

  N-acetylcysteine (NAC) has a long and varied history for supporting many different beneficial mechanisms in the body. It’s an amino acid that plays a significant role in optimal detoxification processes, lung health, and immune function. NAC’s unique ability to increase the production of glutathione, help promote a healthy inflammatory response,  support the body from toxic insults. NAC is proving useful for its ability to up regulate signaling pathways that boost natural, cellular protections against oxidative stress that promotes cellular senescence.  Selenium, L-lysine, molybdenum, zinc, and copper are also included for its synergistic influences especially when used with NAC long-term.  NAC 900+ has a wide range of potential health benefits, including supporting: Acting as an antioxidant to protect cells from damage* Immune function* Helping to clear mucus from the lungs* Inflammation* Detoxifying the body* Cognitive health* Mood disorders* *This item may take longer to ship out*

  Introducing a powerful, cutting-edge supplement designed to support and enhance healthy NAD+ levels—vital for energy, cellular repair, and overall vitality. This innovative formula combines NMN (Nicotinamide Mononucleotide), a precursor to NAD+, with TMG(Trimethylglycine), which helps optimize methylation and support detoxification. Added Pterostilbene, a potent antioxidant, helps protect cells from oxidative stress while promoting healthy aging, and Apigenin, a natural flavonoid, further supports cellular health and cognitive function. Together, these ingredients work synergistically to elevate NAD+ levels, boost energy support, improve metabolic function, and promote longevity. Nicotinamide Mononucleotide: 1,000mg Key Benefits: Boosts NAD+ Levels: Nicotinamide Mononucleotide is a direct precursor to NAD+, an essential molecule for energy production and cellular repair. By replenishing NAD+, NMN combats age-related declines in mitochondrial function and supports optimal metabolism. Supports Longevity Pathways: Nicotinamide Mononucleotide activates sirtuins, enzymes that regulate DNA repair, inflammation control, and cellular health. Enhances Physical and Cognitive Performance: Higher NAD+ levels improve endurance, recovery, and brain function. Scientific Evidence: Studies show Nicotinamide Mononucleotide supplementation restores NAD+ levels, improving mitochondrial function and lifespan in animal models【1】 Human trials demonstrate Nicotinamide Mononucleotide's ability to enhance blood flow and muscle oxygenation【2】 Trimethylglycine (TMG) (as Betaine Anhydrous): 500mg Key Benefits: Supports Methylation Processes: TMG acts as a methyl donor, critical for processing homocysteine into methionine. This helps maintain healthy DNA and supports NMN's conversion into NAD+. Protects Cells from Stress: TMG stabilizes proteins and cell membranes under osmotic stress, ensuring cellular integrity. Supports Heart and Liver Health: Helps support homocysteine levels and cardiovascular risk factors. Scientific Evidence: Research highlights TMG’s role in enhancing cellular methylation and metabolic efficiency【3】【4】 TMG improves physical endurance and energy production in athletes【5】 Pterostilbene: 50mg Key Benefits: Antioxidant Powerhouse: A more bioavailable analog of resveratrol, pterostilbene neutralizes free radicals and protects against oxidative damage. Activates Sirtuins: Supports longevity by enhancing sirtuin activity, which depends on NAD+. Supports Cognitive Function: Protects brain cells from age-related decline, enhancing memory and focus. Scientific Evidence: Studies suggest pterostilbene is more bioavailable and effective than resveratrol at promoting cellular health【6】【7】. Pterostilbene has anti-inflammatory effects, supporting cardiovascular and brain health【8】. Apigenin: 50mg Key Benefits: Inhibits CD38: Apigenin blocks CD38, an enzyme that depletes NAD+ levels, ensuring more NAD+ is available for critical cellular processes. Anti-Inflammatory Properties: Supports chronic inflammation, a key driver of aging and age-related diseases. Protects Against Oxidative Stress: Enhances cellular resilience by reducing oxidative damage to DNA, proteins, and lipids. Scientific Evidence: Research confirms apigenin’s ability to inhibit CD38 and increase NAD+ availability【9】【10】. Apigenin also shows neuroprotective effects, supporting healthy brain aging【11 The Synergy of Science By combining these four powerhouse ingredients,  supports NAD+ production through multiple pathways: NMN: Directly replenishes NAD+ levels. TMG: Facilitates Nicotinamide Mononucleotide metabolism via methylation. Pterostilbene: Protects and enhances NAD+ and Sirtuin activity. Apigenin: Reduces NAD+ depletion by inhibiting CD38. References Mills, K. F., et al. (2016). Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metabolism. Imai, S., & Guarente, L. (2014). NAD+ and sirtuins in aging and disease. Trends in Cell Biology. Craig, S. A. (2004). Betaine in human nutrition. American Journal of Clinical Nutrition. Zhao, X., et al. (2018). TMG alleviates mitochondrial stress by supporting methylation. Cell Reports. Hoffman, J. R., et al. (2009). Betaine supplementation and exercise performance. Journal of the International Society of Sports Nutrition. Remsberg, C. M., et al. (2008). Pharmacokinetics and metabolism of pterostilbene. Life Sciences. Rimando, A. M., et al. (2005). Pterostilbene as an antioxidant. Journal of Agricultural and Food Chemistry. McCormack, D., & McFadden, D. (2013). Pterostilbene and cancer. Antioxidants & Redox Signaling. Chini, C., et al. (2017). CD38 as a regulator of cellular NAD+ homeostasis. Nature Metabolism. Escande, C., et al. (2013). Apigenin and CD38 inhibition. Journal of Molecular Biology. Nabavi, S. F., et al. (2015). Neuroprotective effects of apigenin. Current Neurovascular Research. Additional Key References on  NAD Song, Qin et al. “The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.” Advances in nutrition (Bethesda, Md.) vol. 14,6 (2023): 1416-1435. doi:10.1016/j.advnut.2023.08.008 Yi, Lin et al. “The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial.” GeroScience vol. 45,1 (2023): 29-43. doi:10.1007/s11357-022-00705-1 Soma, Mounica, and Satya Kumar Lalam. “The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions.” Molecular biology reports vol. 49,10 (2022): 9737-9748. doi:10.1007/s11033-022-07459-1 Wei, Zisong et al. “Nicotinamide mononucleotide: An emerging nutraceutical against cardiac aging?.” Current opinion in pharmacology vol. 60 (2021): 291-297. doi:10.1016/j.coph.2021.08.006 Rahman, Sajid Ur et al. “Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging.” Aging and disease vol. 15,2 565-583. 1 Apr. 2024, doi:10.14336/AD.2023.0519-1 Fukamizu, Yuichiro et al. “Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women.” Scientific reports vol. 12,1 14442. 24 Aug. 2022, doi:10.1038/s41598-022-18272-y *This item may take longer to ship out*

Organic Lion’s Mane Extract (Hericium erinaceus)Lion’s Mane is a well-researched nootropic mushroom that helps support healthy brain function and mental clarity. Sourced from the organically cultivated fruiting body, this extract is known to promote neurotrophic activity, which may support cognitive processes such as memory, focus, and concentration. It’s valued for its ability to support both short-term mental performance and long-term brain health. Uridine MonophosphateUridine is a naturally occurring nucleotide that plays a key role in brain cell membrane synthesis and synaptic communication. It helps support neuronal function, learning, and healthy cognitive performance, particularly when combined with key nutrients like DHA and choline. Uridine also plays a role in promoting cellular energy production through mitochondrial pathways. Salidroside (as SalidroPure®)Salidroside is a bioactive compound found in Rhodiola rosea, delivered here in a high-purity, nature-identical form through precision fermentation. It acts as a mitochondrial adaptogen, supporting energy metabolism, resilience to occasional stress, and cognitive endurance. Salidroside may help promote neurotransmitter balance and contribute to mental stamina and mood support, especially during periods of physical or mental strain. L-Ergothioneine (as  MitoPrime®) L-Ergothioneine is a naturally occurring amino acid with antioxidant properties that support the body’s defense against oxidative stress. MitoPrime® delivers a bioavailable form of this compound that is transported into high-energy-demand tissues, such as the brain and liver, via the OCTN1 transporter. It helps maintain mitochondrial function, supports healthy aging, and promotes cellular and cognitive vitality. Together, MitoPrime® and SalidroPure® offer a layered cellular defense system: SalidroPure® supports new mitochondria and boosts energy output MitoPrime® protects existing mitochondria and minimizes oxidative damage The combination also promotes neurotransmitter balance and enhances neurotrophin signaling for optimized cognitive function and mental clarity support. Dihexa Dihexa is a amino-based compound that supports cognitive function and synaptic activity. It is known to promote the formation of new neural connections and may help support memory, learning capacity, and overall brain performance. Dihexa is being studied for its potential to support neuroplasticity, a key component of healthy brain aging.   *This item may take longer to ship out*

Prime Gut Health was created because the digestive system is the foundation of getting and staying healthy. There are many benefits to an optimal digestive system such as a healthy immune system and the protection against harmful viruses, bacteria, fungi, and yeast. The ingredients selected in Prime Gut Health work together to help restore gut homeostasis and GI barrier function.  There are many benefits to taking Prime Gut Health, including:  Supports healthy GI barrier function*   Helps restore gut homeostasis* Binds and neutralizes bacterial toxins in the gut*  Promotes a healthy immune system and respiratory health* Supports digestive health and gut discomfort*  Increased nutrient absorption*  Supports gut inflammation especially within the intestinal wall*  Promotes a healthier GI environment* Promoted regularity and healthy bowel function*  WHAT MAKES PRIME GUT HEALTH SO IMPACTFUL? ImmunoLin® is the branded ingredient serum-derived bovine immunoglobulin/protein isolate (SBI) with over 40 human studies demonstrating its clinical efficacy in digestive and immune health.   SBI has been shown to be a broad-spectrum modulator of the immune system by targeting excessive or imbalanced immunity.* In addition, ImmunoLin® works by binding, neutralizing, and removing pathogenic bacteria, viruses, and other gut irritants that can lead to inflammation.* It also helps to repair the gut lining and restore gut homeostasis.* Tributyrin (as CoreBiome®) is a postbiotic and the most important short-chain fatty acid (SCFA) for supporting digestive, gut, immune and gastrointestinal health. CoreBiome® is a unique butyrate formula intended to pass intact through the stomach and small intestine to deliver butyrate right where it’s needed—the colon.  CoreBiome® supports: Delivery of butyrate to the colon where it helps maintain the integrity of your intestinal lining* Helps repair the gut lining and restore gut homeostasis*  Tight junctures in the intestinal lining*  Regularity and regulation of a normal inflammatory response* Sporebiotics:  Soil-based probiotics have been touted for their stability, ability to improve digestion, stimulate the immune system, and help maintain a healthy gut microbiota. Bacillus coagulans SNZ 1969®, Bacillus subtilis SNZ 1972 and Bacillus clausii SNZ 1971 are supported with an over 50 year history of use and over 30 human studies covering gut health, gastrointestinal discomfort, immunity against GI tract pathogens, inhibition of food borne pathogens, inhibition of bacteria causing dental carries and gingivitis along with bacterial vaginosis. AstraGin® is a 100% natural compound derived from the roots of two traditional Chinese herbs: Panax notoginseng and Astragalus membranaceous,  containing astragaloside I, II, IV and ginsenoside Rb1. AstraGin® enhances nutrient absorption by up-regulating nutrient transporters, such as CAT1, SGLT1, and FR. AstraGin® restores gut wall integrity by triggering an anti-inflammatory response and activating the mTOR pathway for rapid intestinal stem cell migration and differentiation in the inflamed intestinal mucosal barrier (epithelial cell and tight junction). AstraGin® promotes gut ecosystem homeostasis by the symbiotic effect of restoring gut wall integrity and increasing microbiota-immunity communication.  AstraGin® activates the immune system through the symbiotic effect of improved gut wall integrity and enhanced microbiota-immunity communication. AstraGin® demonstrated in a recent published human clinical trial, to improve upon a number of measurable factors relating to gut health making it an ideal addition into Prime Gut Health.    *This item will take longer to ship out*