Healthgevity

BPC-157 is a pentadecapeptide made up of 15 amino acids that is derived from human gastric juice. It has a molecular weight of 2212 daltons and its sequence is: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. BPC-157 is also known as the “Wolverine” peptide, for its ability to help support repair and recovery, many have also found that it’s helped support gut issues, gastric reflux, depression, performance, and more.  BPC-157 has been studied for a variety of topics and has shown to be helpful in many areas such as: tendinopathy, gastric ulcers, general inflammation, and even neuroprotection. BPC-157 seems to work by interacting with our cells’ systems that are responsible for growth and repair, thus helping the body to heal itself. One of the most exciting potential benefits of BPC-157 is its ability to help with tendon repair. Tendons are the tough, fibrous tissues that connect our muscles to our bones and are essential for movement. However, tendons are also susceptible to injury and can often be slow to heal. This is where BPC-157 comes in; by aiding in the repair and regeneration of damaged tendons, BPC-157 could potentially help reduce recovery time and improve outcomes following an injury. BPC-157 has also been shown to be beneficial in supporting the healing of gastric ulcers. Gastric ulcers are a type of peptic ulcer that develops in the lining of the stomach. They are a common and often painful condition that can be difficult to treat. However, BPC-157 has been shown to promote healing of gastric ulcers and improve symptoms. There is also some evidence to suggest that BPC-157 may be helpful in supporting inflammatory bowel disease (IBD). IBD is a chronic condition that causes inflammation of the digestive tract. Symptoms can include abdominal pain, diarrhea, and weight loss. BPC-157 has been shown to reduce inflammation and improve symptoms in animal models of IBD. Overall, BPC-157 appears to be a promising compound with the potential to support a variety of gastrointestinal disorders.  One of the best things about BPC-157 is that it is orally bioavailable, particularly the arginate salt we use, is extremely stable.   We wanted to make sure that oral bioavailability was maximized which is why we included a molecule called SNAC in our formulation. Salcaprozate sodium, or SNAC, is one of the most advanced intestinal permeation enhancers that have been tested in clinical trials for oral delivery of macromolecules. It was originally designed for the oral delivery of insulin. In one study, SNAC increased the absorption of a peptide (a short chain of amino acids) by nine-fold without affecting tight junctions.  Healthgevity's formulation includes an optimal ratio of salcaprozate sodium to our active ingredients. This combination results in exceptional oral absorption of this combination without compromising its stability or efficacy. REFERENCES BPC-157: Staresinic M, Japjec M, Vranes H, Prtoric A, Zizek H, Krezic I, Gojkovic S, Smoday IM, Oroz K, Staresinic E, Dretar V, Yago H, Milavic M, Sikiric S, Lovric E, Batelja Vuletic L, Simeon P, Dobric I, Strbe S, Kokot A, Vlainic J, Blagaic AB, Skrtic A, Seiwerth S, Sikiric P. Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle. Biomedicines. 2022; 10(12):3221. https://doi.org/10.3390/biomedicines10123221 Seiwerth, Sven et al. “BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing.” Current pharmaceutical design vol. 24,18 (2018): 1972-1989. doi:10.2174/1381612824666180712110447 Gwyer, Daniel et al. “Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing.” Cell and tissue research vol. 377,2 (2019): 153-159. doi:10.1007/s00441-019-03016-8 Chang, Chung-Hsun et al. “The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.” Journal of applied physiology (Bethesda, Md. : 1985) vol. 110,3 (2011): 774-80. doi:10.1152/japplphysiol.00945.2010 Sikiric, Predrag et al. “Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications.” Current neuropharmacology vol. 14,8 (2016): 857-865. doi:10.2174/1570159x13666160502153022  Seiwerth, S., Sikiric, P., Grabarevic, Z., Zoricic, I., Hanzevacki, M., Ljubanovic, D., … Kolega, Z. (1997). BPC 157’s effect on Healing. Journal of Physiology Paris, 91(3–5), 173–178. https://doi.org/10.1016/S0928-4257(97)89480-6 Salcaprozate sodium (SNAC): Twarog, Caroline et al. “Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C10).” Pharmaceutics vol. 11,2 78. 13 Feb. 2019, doi:10.3390/pharmaceutics11020078 Zhu Q, Chen Z, Paul PK, Lu Y, Wu W, Qi J. Oral delivery of proteins and peptides: Challenges, status quo and future perspectives. Acta Pharm Sin B. 2021 Aug;11(8):2416-2448. doi: 10.1016/j.apsb.2021.04.001. Epub 2021 Apr 29. PMID: 34522593; PMCID: PMC8424290. Aroda, V.R., Blonde, L. & Pratley, R.E. A new era for oral peptides: SNAC and the development of oral semaglutide for the treatment of type 2 diabetes. Rev Endocr Metab Disord 23, 979–994 (2022). https://doi.org/10.1007/s11154-022-09735-8

BPC+PEA 500 is a synergistic blend of highly orally bio-available BPC-157 (Arginine Salt) with Palmitoylethanolamide (PEA) and added Salcaprozate sodium (SNAC) for enhanced absorption.  This is an ideal formula for anyone looking to support full body repair and regeneration. The peptide BPC-157 is a pentadecapeptide made up of 15 amino acids that is derived from human gastric juice. It has a molecular weight of 2212 daltons and its sequence is: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. BPC-157 is also known as the “Wolverine” peptide, for its ability to help support repair and recovery, many have also found that it’s helped support gut issues, gastric reflux, depression, performance, and more.  BPC-157 has been studied for a variety of topics and has shown to be helpful in many areas such as: tendinopathy, gastric ulcers, general inflammation, and even neuroprotection. BPC-157 seems to work by interacting with our cells’ systems that are responsible for growth and repair, thus helping the body to heal itself. One of the most exciting potential benefits of BPC-157 is its ability to help with tendon repair. Tendons are the tough, fibrous tissues that connect our muscles to our bones and are essential for movement. However, tendons are also susceptible to injury and can often be slow to heal. This is where BPC-157 comes in; by aiding in the repair and regeneration of damaged tendons, BPC-157 could potentially help reduce recovery time and improve outcomes following an injury. BPC-157 has also been shown to be beneficial in supporting the healing of gastric ulcers. Gastric ulcers are a type of peptic ulcer that develops in the lining of the stomach. They are a common and often painful condition that can be difficult to treat. However, BPC-157 has been shown to promote healing of gastric ulcers and improve symptoms. There is also some evidence to suggest that BPC-157 may be helpful in supporting inflammatory bowel disease (IBD). IBD is a chronic condition that causes inflammation of the digestive tract. Symptoms can include abdominal pain, diarrhea, and weight loss. BPC-157 has been shown to reduce inflammation and improve symptoms in animal models of IBD. Overall, BPC-157 appears to be a promising compound with the potential to support a variety of gastrointestinal disorders.  One of the best things about BPC-157 is that it is orally bioavailable, particularly the arginate salt we use, is extremely stable.   We wanted to make sure that oral bioavailability was maximized which is why we included a molecule called SNAC in our formulation. Salcaprozate sodium, or SNAC, is one of the most advanced intestinal permeation enhancers that have been tested in clinical trials for oral delivery of macromolecules. It was originally designed for the oral delivery of insulin. In one study, SNAC increased the absorption of a peptide (a short chain of amino acids) by nine-fold without affecting tight junctions.  Healthgevity's formulation includes an optimal ratio of salcaprozate sodium to our active ingredients. This combination results in exceptional oral absorption of this combination without compromising its stability or efficacy. Palmitoylethanolamide (PEA) is an 18-carbon long- chain fatty acid. Nobel Prize winner Levi-Montalcini identified PEA as a naturally occurring molecule, describing its value in treating chronic infections and pain. Following her discovery, hundreds of scientific studies have been published to show that it is very effective and safe to use. PEA is thought to work by supporting the inflammatory response through the PPAR-a receptor, COX-2 and through effects on NF-kappaB signaling while also by restoring balance in the endocannabinoid system. Its mechanism of action is similar to that of non-steroidal anti-inflammatory drugs (NSAIDs). Palmitoylethanolamide (PEA) is the body’s go-to- molecule and is made on demand when required under disease conditions.  This naturally occurs to help resolve inflammation and pain to restore the body to a normal, health state. Due to its ubiquitous nature and presence in all cells, PEA has wide-ranging therapeutic applications. Some of the most common clinical applications are analgesic effects, chronic pain, and inflammation support. PEA has anti-inflammatory effects on the body by inhibiting the production of pro-inflammatory cytokines and by reducing the activity of activated microglia cells. It is also thought to reduce pain by modulating the neurotransmitters involved in pain signaling. In addition to its analgesic and anti-inflammatory effects, PEA is also thought to offer neuroprotection by reducing the levels of reactive oxygen species and by modulating cell death pathways. It has also been shown to improve cognitive function in animal models of Alzheimer's disease. The endocannabinoid system is involved in a wide range of physiological processes, including digestion. The role of the endocannabinoid system in the gut has been studied extensively and it is now well-established that cannabinoids modulate gastrointestinal motility, secretion and inflammation. PEA is one of the most abundant endocannabinoids in the gut and is thought to play a key role in gut-brain axis. The endocannabinoid system is known to be involved in various digestive disorders, such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD). Several studies have shown that PEA is effective in reducing symptoms of IBS, such as abdominal pain and bloating. A recent clinical trial showed that a PEA-based product was able to significantly reduce IBS symptoms in patients who did not respond to standard therapy. PEA has also been shown to be effective in supporting other digestive disorders such as GERD and IBD. In a clinical trial, PEA was able to significantly reduce symptoms of GERD, such as heartburn and acid reflux.   *This item may take longer to ship*

Brain Boost+ is a powerful combination of paraxanthine, alpha-GPC, lion’s mane, N-acetyl L-tyrosine (NALT) and L-Theanine help to increase energy levels, cognitive function, motivation, and focus all while reducing fatigue. Brain Boost+ may also aid in the prevention of age-related cognitive decline and has neuroprotective properties without the jitters or crash.  The ingredients included in Brain Boost+ have shown positive changes in brain wave activity specifically delta and theta waves which are associated with focus and decision making under pressure, making it the ideal formula to utilize when needing a desired edge.  Paraxanthine (enfinity®) is caffeine’s primary metabolite in the human body, contributing to the vast majority of caffeine’s beneficial effects. It is a central nervous system stimulant without the toxicity associated with caffeine and has shown greater benefits than caffeine itself. Caffeine has numerous issues with the gene (CYP1A2, caffeine metabolizer gene), where some are slow metabolizers and deal with much of the side effects and fast metabolizers get little of the benefits.  Only about 30% are ideal metabolizers of caffeine leading to much diversity in how it is experienced. When ingested, enfinity® functions more consistently than caffeine, leading to fewer side effects, greater enjoyability, improved mood, and a more focused mindset.  Multiple studies have shown those benefits to include:  Energy, focus, and wakeful clarity. Enhanced mood and sense of wellbeing. Neuroprotective cognitive accelerant. Improved reaction time and reduced mental errors. Increased caloric expenditure and thermogenesis. Significantly lessened side effects of caffeine with dramatically reduced toxicity. More consistent results: eliminates caffeine’s genetic variability, reducing crashes and anxiety. Alpha-GPC or Alpha-Glycerophoscholine, is a natural compound found in the brain that also exists in small amounts in certain foods.  It’s known for its potential cognitive enhancement and physical performance properties. GeniusPure®Alpha-GPC is a new breakthrough version, 90% yield that is engineered to be hygroscopically stable. Various studies show alpha-GPC supports cognitive function, memory and learning.  Alpha-GPC is a precursor to acetylcholine, a neurotransmitter critical for brain health and crosses the blood-brain barrier.  Lion’s Mane (Hericium erinaceus) is a type of mushroom that has been used in traditional medicine for its potential health benefits especially for the brain.  Lion’s Mane contains compounds that may stimulate the production of nerve growth factor (NGF) in the brain.  NGF is involved in the growth, maintenance, and survival of neurons.  By promoting NGF production, Lion’s Mane may support brain health and cognitive function. N-acetyl L-tyrosine (NALT) is a modified form of the amino acid L-tyrosine.  Tyrosine is a precursor to several important neurotransmitters, including dopamine, norepinephrine, and epinephrine.  These neurotransmitters play key roles in mood regulation, focus, attention, stress support and cognitive function. L-Theanine is an amino acid known for its calming effects and potential benefits for relaxation, focus and cognitive function.   It is known to have a synergistic effect when paired with paraxanthine promoting alertness and focus without the jittery side effects often associated with caffeine use. L-Theanine can cross the blood-brain barrier and affect various neurotransmitters in the brain such as GABA, serotonin and dopamine. It is also known to increase alpha brain wave activity which is associated with a relaxed but alert mental state. *This item may take longer to ship out* 

Prime Gut Health was created because the digestive system is the foundation of getting and staying healthy. There are many benefits to an optimal digestive system such as a healthy immune system and the protection against harmful viruses, bacteria, fungi, and yeast. The ingredients selected in Prime Gut Health work together to help restore gut homeostasis and GI barrier function.  There are many benefits to taking Prime Gut Health, including:  Supports healthy GI barrier function*   Helps restore gut homeostasis* Binds and neutralizes bacterial toxins in the gut*  Promotes a healthy immune system and respiratory health* Supports digestive health and gut discomfort*  Increased nutrient absorption*  Supports gut inflammation especially within the intestinal wall*  Promotes a healthier GI environment* Promoted regularity and healthy bowel function*  WHAT MAKES PRIME GUT HEALTH SO IMPACTFUL? ImmunoLin® is the branded ingredient serum-derived bovine immunoglobulin/protein isolate (SBI) with over 40 human studies demonstrating its clinical efficacy in digestive and immune health.   SBI has been shown to be a broad-spectrum modulator of the immune system by targeting excessive or imbalanced immunity.* In addition, ImmunoLin® works by binding, neutralizing, and removing pathogenic bacteria, viruses, and other gut irritants that can lead to inflammation.* It also helps to repair the gut lining and restore gut homeostasis.* Tributyrin (as CoreBiome®) is a postbiotic and the most important short-chain fatty acid (SCFA) for supporting digestive, gut, immune and gastrointestinal health. CoreBiome® is a unique butyrate formula intended to pass intact through the stomach and small intestine to deliver butyrate right where it’s needed—the colon.  CoreBiome® supports: Delivery of butyrate to the colon where it helps maintain the integrity of your intestinal lining* Helps repair the gut lining and restore gut homeostasis*  Tight junctures in the intestinal lining*  Regularity and regulation of a normal inflammatory response* Sporebiotics:  Soil-based probiotics have been touted for their stability, ability to improve digestion, stimulate the immune system, and help maintain a healthy gut microbiota. Bacillus coagulans SNZ 1969®, Bacillus subtilis SNZ 1972 and Bacillus clausii SNZ 1971 are supported with an over 50 year history of use and over 30 human studies covering gut health, gastrointestinal discomfort, immunity against GI tract pathogens, inhibition of food borne pathogens, inhibition of bacteria causing dental carries and gingivitis along with bacterial vaginosis. AstraGin® is a 100% natural compound derived from the roots of two traditional Chinese herbs: Panax notoginseng and Astragalus membranaceous,  containing astragaloside I, II, IV and ginsenoside Rb1. AstraGin® enhances nutrient absorption by up-regulating nutrient transporters, such as CAT1, SGLT1, and FR. AstraGin® restores gut wall integrity by triggering an anti-inflammatory response and activating the mTOR pathway for rapid intestinal stem cell migration and differentiation in the inflamed intestinal mucosal barrier (epithelial cell and tight junction). AstraGin® promotes gut ecosystem homeostasis by the symbiotic effect of restoring gut wall integrity and increasing microbiota-immunity communication.  AstraGin® activates the immune system through the symbiotic effect of improved gut wall integrity and enhanced microbiota-immunity communication. AstraGin® demonstrated in a recent published human clinical trial, to improve upon a number of measurable factors relating to gut health making it an ideal addition into Prime Gut Health.    *This item will take longer to ship*