- Activated Broccoli Raffinate seed
- Sulforaphane Glucosinolate
- Myrosinase Enzyme
- Pomegranate Extract
- Pterocarpus Marsupium pulp
- Ginkgo Biloba Extract leaf
- Dong Quai root
- Trans-Resveratrol root
- Grapeseed Extract
- provides support for the Nrf2 process in cells that create antioxidants & Phase II enzyme
- Supports cellular integrity and stabilizes proteins
Your Nrf2 pathway is your primary intracellular path to detoxify oxidizing agents. Failure for Nrf2 to be released to do its job (common with Keap1 gene defects) and Nrf2 production (NFE2 gene defects) may decrease Nrf2 function and be a cause of severe illness.
Description - Nrf2 Basics
Nrf2, or nuclear factor erythroid-2-related factor 2, is a master transcription factor for hundreds of human genes involved in cell protection and detoxification. Nrf2 protects cells against oxidative stress and environmental toxins through the induction of cytoprotective genes.
Cells devote great energy to maintaining the Nrf2 pathway, ensuring its rapid induction upon cellular insult, with return to normal levels once the threat has been neutralized.
Key Nrf2 Actions
Nrf2 has four key domains:
1. Nrf2 quells oxidative stress by stimulating key antioxidant enzymes such as heme oxygenase and glutathionerelated enzymes.
2. Nrf2 damps inflammation by down-regulating pro-inflammatory cytokines such as interleukins and NFkappaB, and by up-regulating antioxidant responses.[1,3]
3. Nrf2 promotes mitochondrial biogenesis and improves mitochondrial function, with all that that implies.
4. Nrf2 stimulates autophagy, which removes damaged and toxic molecules and aggregates [1,4] (see tech info sheet: Autophagy Assist).
The Nrf2 pathway can be induced by a wide variety of dietary and plant chemicals, by low-level oxidative stress (hormesis effect), and by exercise and caloric restriction. Healthy diets such as the Mediterranean and Okinawan diets, "paleo" diets emphasizing a variety of vegetables, and WFPB (whole food plant-based) diets, are rich in compounds that boost Nrf2.
The Standard American Diet (SAD), loaded with refined sugars and fats, is sadly lacking in same. Nrf2 appears to be the final common pathway for the protective effects of a plethora of the best-documented phytochemicals including phenolic antioxidants (grapes, grape seed, pomegranate, green tea), sulforaphane (broccoli and other crucifers), carotenoids (red, green and yellow vegetables), and omega-3 fatty acids.