Hista Clear - DAO Enzyme (60 tablets)

{"id":2150888407104,"title":"Hista Clear - DAO Enzyme (60 tablets)","handle":"hista-clear-dao-enzyme","description":"\u003cp class=\"page\" title=\"Page 2\"\u003e\u003cspan style=\"color: #ff2a00;\"\u003e\u003cstrong\u003eNEW: Now in NEW packaging\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"page\" title=\"Page 2\"\u003eConners Clinic Originals Hista Clear is a patented enzyme formula containing diamine oxidase (DAO) - the main enzyme responsible for the degradation of ingested histamine.  This enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract.  \u003cbr\u003e\u003c\/p\u003e\n\u003cdiv class=\"page\" title=\"Page 2\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"page\" title=\"Page 2\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"page\" title=\"Page 2\"\u003e\n\u003cdiv class=\"layoutArea\"\u003e\n\u003cdiv class=\"column\"\u003e\n\u003cdiv class=\"page\" title=\"Page 1\"\u003e\n\u003cdiv class=\"section\"\u003e\n\u003cp\u003eOur bodies are complex, and there is usually more at play than we think. What most don’t take into consideration when addressing histamine-related health issues is genetics. Whether you’re on a low histamine diet due to histamine intolerance, or simply trying to reduce high histamine foods for general health, you will benefit from understanding how your genes are related. Learn more about\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.connersclinic.com\/histamine-and-your-genes\/\" target=\"_blank\"\u003ehistamine and genetics here\u003c\/a\u003e!\u003c\/p\u003e\n\u003cp\u003eOur body has two distinct methods of clearing things that could bring it harm: our immune system kills living toxins (bacteria, virus, parasites…) and our detoxification pathways clear non-living toxins (chemicals, heavy metals, drugs…). We have one other system that sits somewhere in the middle between the immune and the detoxification systems that helps with both: the mast cells. Read more about\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.connersclinic.com\/histamines-double-edge-sword-in-the-formation-and-progression-of-cancer\/\" target=\"_blank\"\u003eHistamine’s Double-edge Sword in the Formation and Progression of Cancer\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e \u003ciframe height=\"400\" width=\"700\" src=\"https:\/\/videos.connersclinic.com\/embed\/rJVL2SUm8dbqMLV?color=04abf2\" allowfullscreen=\"\" frameborder=\"0\"\u003e\u003c\/iframe\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdl\u003e\n\u003cdt\u003e\u003cstrong\u003eClinical Applications\u003c\/strong\u003e\u003c\/dt\u003e\n\u003cdd\u003e\n\u003cul\u003e\n\u003cli\u003eSupports Healthy Degradation of Food-Derived Histamine*\u003c\/li\u003e\n\u003cli\u003eEnhances the Presence of Diamine Oxidase in the Digestive Tract*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/dd\u003e\n\u003c\/dl\u003e\n\u003cdl class=\"mt-3\" id=\"longDescription\"\u003e\n\u003cdt\u003e\u003cstrong\u003eDescription:\u003c\/strong\u003e\u003c\/dt\u003e\n\u003cdd\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cmeta charset=\"utf-8\"\u003eHista Clear \u003c\/span\u003eprovides a concentrated source of diamine oxidase (DAO)—the main enzyme responsible for the degradation of ingested histamine. This formula delivers the clinically researched dose of DAO in an easy-to-swallow, gastro-resistant mini-tablet, which is essential for releasing DAO in the small intestine, where it breaks down food-derived histamine. HistDAO does not manage or address antibody-related or IgE-related food allergies.*\u003c\/p\u003e\n\u003c\/dd\u003e\n\u003c\/dl\u003e\n\u003cp\u003e\u003cstrong style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003eDiscussion:\u003c\/strong\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eHistamine is a bioactive or “vasoactive” amine produced in the body in response to an injury or foreign substance. It has an array of physiological effects, including increasing blood supply to specific sites in the body. In addition, histamine is involved in the immune response, regulation of gastric acid, permeability of blood vessels, contraction of muscles, and the normal response to inflammation.[1] The highest concentrations of histamine in the body are found in the gastrointestinal tract, lungs, and skin, with lesser amounts in the brain and heart.*\u003c\/p\u003e\n\u003cp\u003eHistamine is not only produced in the body but is also present in many fermented foods, such as sauerkraut, sausage, cheese, yogurt, and alcoholic beverages. Tuna, olives, spinach, eggplant, avocados, tomatoes, cherries, and citrus fruits are other histamine-containing foods. Despite their absence of histamine, some foods, such as berries, tea, and a variety of spices, stimulate the endogenous production of the amine due to their benzoate content. In addition, microbial fermentation can convert the histidine in high-protein foods to histamine so that the histamine content of food can increase over time.*[1]\u003c\/p\u003e\n\u003cp\u003eEndogenous and exogenous histamine must be broken down in order to maintain homeostasis and histamine balance. The enzyme diamine oxidase (DAO) degrades histamine by converting it from 2-(4-imidazolyl)- ethylamine to the inactive metabolite imidazole acetaldehyde.[2] The active ingredient in HistaClear is porcine-derived diamine oxidase, and research suggests that DAO derived from porcine kidney appears to have identical action to DAO derived from porcine intestine.[3] In humans and other mammals, DAO is found in high concentrations in the gastrointestinal mucosa. Animal studies suggest that circulating DAO may be a marker for mucosal integrity and maturity.[4] Certain drugs may affect histamine balance in the body by promoting histamine release or inhibiting DAO.*[2]\u003c\/p\u003e\n\u003cp\u003eHistamine tolerance may not be the same for everyone. Results of a double-blind, placebo-controlled crossover study suggest that tolerance to histamine can vary from individual to individual.[5] Total body histamine load must be considered when evaluating histamine tolerance, and a balance between histamine and DAO appears to be crucial to maintaining skin, rhinoconjunctival, and gastrointestinal health.[2,6] Genetic and environmental factors may interact to influence DAO expression. Ongoing research addresses the role that genetic variations may play in individual differences in DAO metabolism, and serum activity was significantly associated with seven single nucleotide variations within the DAO gene.[7,8] Histamine tolerance may be reflected in detailed questionnaires, food intake logs, trial with low-histamine diet, and measurement of DAO and histamine.*[9,10]\u003c\/p\u003e\n\u003cp\u003eHistamine tolerance and its manifestation may vary from organ to organ as well. A study of 39 patients suggested that intake of DAO produced a statistically significant reduction in symptoms associated with exogenous histamine ingestion, although single symptoms were not found to be reproducible.*[11]\u003c\/p\u003e\n\u003cp\u003eUltimately, diminished serum DAO levels appear to be associated with changes in histamine degradation and serum histamine levels.[10] Although the mechanism of histamine degradation is uniform throughout the body, HistaClear only addresses excess exogenous histamine found in the folds, villi, and microvilli of the small intestine. HistaClear is not absorbed and therefore does not have systemic activity. A two-capsule dose of HistaClear contains 20 mg of vitamin C and 20,000 HDU (histamine degrading units) from diamine oxidase. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eRead our article: \u003ca href=\"https:\/\/www.connersclinic.com\/low-histamine-diet-the-food-list\/\" title=\"Low Histamine Diet: The High Histamine Foods List\" target=\"_blank\"\u003eLow Histamine Diet: The High Histamine Foods List\u003c\/a\u003e\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cb\u003e\u003ci\u003eGenetic supplementation is complex and requires a deep understanding of the entire genetic picture.\u003cspan class=\"Apple-converted-space\"\u003e  \u003c\/span\u003eOur \u003c\/i\u003e\u003c\/b\u003e\u003ca href=\"https:\/\/shop.connersclinic.com\/collections\/memberships\/products\/genetic-review\"\u003e\u003cspan class=\"s1\"\u003e\u003cb\u003e\u003ci\u003eGenetics Membership\u003c\/i\u003e\u003c\/b\u003e\u003c\/span\u003e\u003c\/a\u003e\u003cb\u003e\u003ci\u003e includes the kit, a full workup, review, report, summary, Dr. Conners’ personalized recommendations - and MORE.\u003cspan class=\"Apple-converted-space\"\u003e  \u003c\/span\u003eClick \u003c\/i\u003e\u003c\/b\u003e\u003ca href=\"https:\/\/shop.connersclinic.com\/collections\/memberships\/products\/genetic-review\"\u003e\u003cspan class=\"s1\"\u003e\u003cb\u003e\u003ci\u003eHERE\u003c\/i\u003e\u003c\/b\u003e\u003c\/span\u003e\u003c\/a\u003e\u003cb\u003e\u003ci\u003e for details.\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"layoutArea\"\u003e\u003cstrong\u003eVideo:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"layoutArea\"\u003e\n\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003ciframe src=\"https:\/\/www.youtube.com\/embed\/4JzCBWb8HvY\" width=\"540\" height=\"355\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen=\"\" frameborder=\"0\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTake 1-2 capsules no more than 15 minutes before the consumption of histamine-rich foods, or take as directed by your healthcare practitioner.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCautions:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eConsult your healthcare practitioner before use, especially if you are pregnant or nursing. Keep out of reach of children. Avoid if allergic to pork or any other ingredient. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cvideo width=\"540\" height=\"355\" controls=\"controls\"\u003e\n \u003csource src=\"https:\/\/21431710.fs1.hubspotusercontent-na1.net\/hubfs\/21431710\/Whats%20the%20Difference%20Between%20Hista%20Clear%20and%20Clear%20Histamine%20Scavenger%3F.mp4\" type=\"video\/mp4\"\u003e\n Your browser does not support the video tag.\n \u003c\/source\u003e\u003c\/video\u003e\u003c\/p\u003e","published_at":"2020-05-22T08:55:20-05:00","created_at":"2019-01-03T20:37:30-06:00","vendor":"Conners Clinic","type":"Supplement","tags":["Wholesale"],"price":6400,"price_min":6400,"price_max":6400,"available":true,"price_varies":false,"compare_at_price":8400,"compare_at_price_min":8400,"compare_at_price_max":8400,"compare_at_price_varies":false,"variants":[{"id":20393408102464,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"","requires_shipping":true,"taxable":true,"featured_image":null,"available":true,"name":"Hista Clear - 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DAO Enzyme Conners Clinic Supplement - Conners Clinic","id":22403680108710,"position":3,"preview_image":{"aspect_ratio":2.155,"height":328,"width":707,"src":"\/\/shop.connersclinic.com\/cdn\/shop\/products\/hista-clear-dao-enzyme-conners-clinic-conners-clinic-29942487548070.jpg?v=1704381585"},"aspect_ratio":2.155,"height":328,"media_type":"image","src":"\/\/shop.connersclinic.com\/cdn\/shop\/products\/hista-clear-dao-enzyme-conners-clinic-conners-clinic-29942487548070.jpg?v=1704381585","width":707}],"requires_selling_plan":false,"selling_plan_groups":[{"id":"5f8d65106e24918d4c8d98151c70432075c719c9","name":"Subscribe for 5% off","options":[{"name":"Deliver every","position":1,"values":["2 weeks","3 weeks","month","6 weeks","2 months","10 weeks","3 months","4 months"]}],"selling_plans":[{"id":533004454,"name":"2 Week Subscription","description":"5% 𝙙𝙞𝙨𝙘𝙤𝙪𝙣𝙩 𝙨𝙩𝙖𝙧𝙩𝙞𝙣𝙜 𝙤𝙣 𝙮𝙤𝙪𝙧 𝙨𝙚𝙘𝙤𝙣𝙙 𝙤𝙧𝙙𝙚𝙧","options":[{"name":"Deliver every","position":1,"value":"2 weeks"}],"recurring_deliveries":true,"price_adjustments":[{"order_count":1,"position":1,"value_type":"percentage","value":0},{"order_count":null,"position":2,"value_type":"percentage","value":5}],"checkout_charge":{"value_type":"percentage","value":100}},{"id":28511371484,"name":"3 week subscription","description":"5% 𝙙𝙞𝙨𝙘𝙤𝙪𝙣𝙩 𝙨𝙩𝙖𝙧𝙩𝙞𝙣𝙜 𝙤𝙣 𝙮𝙤𝙪𝙧 𝙨𝙚𝙘𝙤𝙣𝙙 𝙤𝙧𝙙𝙚𝙧","options":[{"name":"Deliver every","position":1,"value":"3 weeks"}],"recurring_deliveries":true,"price_adjustments":[{"order_count":1,"position":1,"value_type":"percentage","value":0},{"order_count":null,"position":2,"value_type":"percentage","value":5}],"checkout_charge":{"value_type":"percentage","value":100}},{"id":530776230,"name":"Monthly Subscription","description":"5% 𝙙𝙞𝙨𝙘𝙤𝙪𝙣𝙩 𝙨𝙩𝙖𝙧𝙩𝙞𝙣𝙜 𝙤𝙣 𝙮𝙤𝙪𝙧 𝙨𝙚𝙘𝙤𝙣𝙙 𝙤𝙧𝙙𝙚𝙧","options":[{"name":"Deliver every","position":1,"value":"month"}],"recurring_deliveries":true,"price_adjustments":[{"order_count":1,"position":1,"value_type":"percentage","value":0},{"order_count":null,"position":2,"value_type":"percentage","value":5}],"checkout_charge":{"value_type":"percentage","value":100}},{"id":533037222,"name":"6 Week Subscription","description":"5% 𝙙𝙞𝙨𝙘𝙤𝙪𝙣𝙩 𝙨𝙩𝙖𝙧𝙩𝙞𝙣𝙜 𝙤𝙣 𝙮𝙤𝙪𝙧 𝙨𝙚𝙘𝙤𝙣𝙙 𝙤𝙧𝙙𝙚𝙧","options":[{"name":"Deliver every","position":1,"value":"6 weeks"}],"recurring_deliveries":true,"price_adjustments":[{"order_count":1,"position":1,"value_type":"percentage","value":0},{"order_count":null,"position":2,"value_type":"percentage","value":5}],"checkout_charge":{"value_type":"percentage","value":100}},{"id":530808998,"name":"2 Month Subscription","description":"5% 𝙙𝙞𝙨𝙘𝙤𝙪𝙣𝙩 𝙨𝙩𝙖𝙧𝙩𝙞𝙣𝙜 𝙤𝙣 𝙮𝙤𝙪𝙧 𝙨𝙚𝙘𝙤𝙣𝙙 𝙤𝙧𝙙𝙚𝙧","options":[{"name":"Deliver every","position":1,"value":"2 months"}],"recurring_deliveries":true,"price_adjustments":[{"order_count":1,"position":1,"value_type":"percentage","value":0},{"order_count":null,"position":2,"value_type":"percentage","value":5}],"checkout_charge":{"value_type":"percentage","value":100}},{"id":23582376156,"name":"10 week subscription","description":"5% 𝙙𝙞𝙨𝙘𝙤𝙪𝙣𝙩 𝙨𝙩𝙖𝙧𝙩𝙞𝙣𝙜 𝙤𝙣 𝙮𝙤𝙪𝙧 𝙨𝙚𝙘𝙤𝙣𝙙 𝙤𝙧𝙙𝙚𝙧","options":[{"name":"Deliver every","position":1,"value":"10 weeks"}],"recurring_deliveries":true,"price_adjustments":[{"order_count":1,"position":1,"value_type":"percentage","value":0},{"order_count":null,"position":2,"value_type":"percentage","value":5}],"checkout_charge":{"value_type":"percentage","value":100}},{"id":22287089884,"name":"3 Month subscription","description":"5% 𝙙𝙞𝙨𝙘𝙤𝙪𝙣𝙩 𝙨𝙩𝙖𝙧𝙩𝙞𝙣𝙜 𝙤𝙣 𝙮𝙤𝙪𝙧 𝙨𝙚𝙘𝙤𝙣𝙙 𝙤𝙧𝙙𝙚𝙧","options":[{"name":"Deliver every","position":1,"value":"3 months"}],"recurring_deliveries":true,"price_adjustments":[{"order_count":1,"position":1,"value_type":"percentage","value":0},{"order_count":null,"position":2,"value_type":"percentage","value":5}],"checkout_charge":{"value_type":"percentage","value":100}},{"id":24937955548,"name":"4 Month subscription","description":"5% 𝙙𝙞𝙨𝙘𝙤𝙪𝙣𝙩 𝙨𝙩𝙖𝙧𝙩𝙞𝙣𝙜 𝙤𝙣 𝙮𝙤𝙪𝙧 𝙨𝙚𝙘𝙤𝙣𝙙 𝙤𝙧𝙙𝙚𝙧","options":[{"name":"Deliver every","position":1,"value":"4 months"}],"recurring_deliveries":true,"price_adjustments":[{"order_count":1,"position":1,"value_type":"percentage","value":0},{"order_count":null,"position":2,"value_type":"percentage","value":5}],"checkout_charge":{"value_type":"percentage","value":100}}],"app_id":"Seal Subscriptions"}],"content":"\u003cp class=\"page\" title=\"Page 2\"\u003e\u003cspan style=\"color: #ff2a00;\"\u003e\u003cstrong\u003eNEW: Now in NEW packaging\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"page\" title=\"Page 2\"\u003eConners Clinic Originals Hista Clear is a patented enzyme formula containing diamine oxidase (DAO) - the main enzyme responsible for the degradation of ingested histamine.  This enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract.  \u003cbr\u003e\u003c\/p\u003e\n\u003cdiv class=\"page\" title=\"Page 2\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"page\" title=\"Page 2\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003cdiv class=\"page\" title=\"Page 2\"\u003e\n\u003cdiv class=\"layoutArea\"\u003e\n\u003cdiv class=\"column\"\u003e\n\u003cdiv class=\"page\" title=\"Page 1\"\u003e\n\u003cdiv class=\"section\"\u003e\n\u003cp\u003eOur bodies are complex, and there is usually more at play than we think. What most don’t take into consideration when addressing histamine-related health issues is genetics. Whether you’re on a low histamine diet due to histamine intolerance, or simply trying to reduce high histamine foods for general health, you will benefit from understanding how your genes are related. Learn more about\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.connersclinic.com\/histamine-and-your-genes\/\" target=\"_blank\"\u003ehistamine and genetics here\u003c\/a\u003e!\u003c\/p\u003e\n\u003cp\u003eOur body has two distinct methods of clearing things that could bring it harm: our immune system kills living toxins (bacteria, virus, parasites…) and our detoxification pathways clear non-living toxins (chemicals, heavy metals, drugs…). We have one other system that sits somewhere in the middle between the immune and the detoxification systems that helps with both: the mast cells. Read more about\u003cspan\u003e \u003c\/span\u003e\u003ca href=\"https:\/\/www.connersclinic.com\/histamines-double-edge-sword-in-the-formation-and-progression-of-cancer\/\" target=\"_blank\"\u003eHistamine’s Double-edge Sword in the Formation and Progression of Cancer\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e \u003ciframe height=\"400\" width=\"700\" src=\"https:\/\/videos.connersclinic.com\/embed\/rJVL2SUm8dbqMLV?color=04abf2\" allowfullscreen=\"\" frameborder=\"0\"\u003e\u003c\/iframe\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cdl\u003e\n\u003cdt\u003e\u003cstrong\u003eClinical Applications\u003c\/strong\u003e\u003c\/dt\u003e\n\u003cdd\u003e\n\u003cul\u003e\n\u003cli\u003eSupports Healthy Degradation of Food-Derived Histamine*\u003c\/li\u003e\n\u003cli\u003eEnhances the Presence of Diamine Oxidase in the Digestive Tract*\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/dd\u003e\n\u003c\/dl\u003e\n\u003cdl class=\"mt-3\" id=\"longDescription\"\u003e\n\u003cdt\u003e\u003cstrong\u003eDescription:\u003c\/strong\u003e\u003c\/dt\u003e\n\u003cdd\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cmeta charset=\"utf-8\"\u003eHista Clear \u003c\/span\u003eprovides a concentrated source of diamine oxidase (DAO)—the main enzyme responsible for the degradation of ingested histamine. This formula delivers the clinically researched dose of DAO in an easy-to-swallow, gastro-resistant mini-tablet, which is essential for releasing DAO in the small intestine, where it breaks down food-derived histamine. HistDAO does not manage or address antibody-related or IgE-related food allergies.*\u003c\/p\u003e\n\u003c\/dd\u003e\n\u003c\/dl\u003e\n\u003cp\u003e\u003cstrong style=\"font-family: -apple-system, BlinkMacSystemFont, 'San Francisco', 'Segoe UI', Roboto, 'Helvetica Neue', sans-serif; font-size: 0.875rem;\"\u003eDiscussion:\u003c\/strong\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eHistamine is a bioactive or “vasoactive” amine produced in the body in response to an injury or foreign substance. It has an array of physiological effects, including increasing blood supply to specific sites in the body. In addition, histamine is involved in the immune response, regulation of gastric acid, permeability of blood vessels, contraction of muscles, and the normal response to inflammation.[1] The highest concentrations of histamine in the body are found in the gastrointestinal tract, lungs, and skin, with lesser amounts in the brain and heart.*\u003c\/p\u003e\n\u003cp\u003eHistamine is not only produced in the body but is also present in many fermented foods, such as sauerkraut, sausage, cheese, yogurt, and alcoholic beverages. Tuna, olives, spinach, eggplant, avocados, tomatoes, cherries, and citrus fruits are other histamine-containing foods. Despite their absence of histamine, some foods, such as berries, tea, and a variety of spices, stimulate the endogenous production of the amine due to their benzoate content. In addition, microbial fermentation can convert the histidine in high-protein foods to histamine so that the histamine content of food can increase over time.*[1]\u003c\/p\u003e\n\u003cp\u003eEndogenous and exogenous histamine must be broken down in order to maintain homeostasis and histamine balance. The enzyme diamine oxidase (DAO) degrades histamine by converting it from 2-(4-imidazolyl)- ethylamine to the inactive metabolite imidazole acetaldehyde.[2] The active ingredient in HistaClear is porcine-derived diamine oxidase, and research suggests that DAO derived from porcine kidney appears to have identical action to DAO derived from porcine intestine.[3] In humans and other mammals, DAO is found in high concentrations in the gastrointestinal mucosa. Animal studies suggest that circulating DAO may be a marker for mucosal integrity and maturity.[4] Certain drugs may affect histamine balance in the body by promoting histamine release or inhibiting DAO.*[2]\u003c\/p\u003e\n\u003cp\u003eHistamine tolerance may not be the same for everyone. Results of a double-blind, placebo-controlled crossover study suggest that tolerance to histamine can vary from individual to individual.[5] Total body histamine load must be considered when evaluating histamine tolerance, and a balance between histamine and DAO appears to be crucial to maintaining skin, rhinoconjunctival, and gastrointestinal health.[2,6] Genetic and environmental factors may interact to influence DAO expression. Ongoing research addresses the role that genetic variations may play in individual differences in DAO metabolism, and serum activity was significantly associated with seven single nucleotide variations within the DAO gene.[7,8] Histamine tolerance may be reflected in detailed questionnaires, food intake logs, trial with low-histamine diet, and measurement of DAO and histamine.*[9,10]\u003c\/p\u003e\n\u003cp\u003eHistamine tolerance and its manifestation may vary from organ to organ as well. A study of 39 patients suggested that intake of DAO produced a statistically significant reduction in symptoms associated with exogenous histamine ingestion, although single symptoms were not found to be reproducible.*[11]\u003c\/p\u003e\n\u003cp\u003eUltimately, diminished serum DAO levels appear to be associated with changes in histamine degradation and serum histamine levels.[10] Although the mechanism of histamine degradation is uniform throughout the body, HistaClear only addresses excess exogenous histamine found in the folds, villi, and microvilli of the small intestine. HistaClear is not absorbed and therefore does not have systemic activity. A two-capsule dose of HistaClear contains 20 mg of vitamin C and 20,000 HDU (histamine degrading units) from diamine oxidase. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.*\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eRead our article: \u003ca href=\"https:\/\/www.connersclinic.com\/low-histamine-diet-the-food-list\/\" title=\"Low Histamine Diet: The High Histamine Foods List\" target=\"_blank\"\u003eLow Histamine Diet: The High Histamine Foods List\u003c\/a\u003e\u003c\/strong\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp class=\"p1\"\u003e\u003cb\u003e\u003ci\u003eGenetic supplementation is complex and requires a deep understanding of the entire genetic picture.\u003cspan class=\"Apple-converted-space\"\u003e  \u003c\/span\u003eOur \u003c\/i\u003e\u003c\/b\u003e\u003ca href=\"https:\/\/shop.connersclinic.com\/collections\/memberships\/products\/genetic-review\"\u003e\u003cspan class=\"s1\"\u003e\u003cb\u003e\u003ci\u003eGenetics Membership\u003c\/i\u003e\u003c\/b\u003e\u003c\/span\u003e\u003c\/a\u003e\u003cb\u003e\u003ci\u003e includes the kit, a full workup, review, report, summary, Dr. Conners’ personalized recommendations - and MORE.\u003cspan class=\"Apple-converted-space\"\u003e  \u003c\/span\u003eClick \u003c\/i\u003e\u003c\/b\u003e\u003ca href=\"https:\/\/shop.connersclinic.com\/collections\/memberships\/products\/genetic-review\"\u003e\u003cspan class=\"s1\"\u003e\u003cb\u003e\u003ci\u003eHERE\u003c\/i\u003e\u003c\/b\u003e\u003c\/span\u003e\u003c\/a\u003e\u003cb\u003e\u003ci\u003e for details.\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"layoutArea\"\u003e\u003cstrong\u003eVideo:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"layoutArea\"\u003e\n\u003cstrong\u003e\u003c\/strong\u003e\u003cbr\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003ciframe src=\"https:\/\/www.youtube.com\/embed\/4JzCBWb8HvY\" width=\"540\" height=\"355\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen=\"\" frameborder=\"0\"\u003e\u003c\/iframe\u003e\u003c\/p\u003e\n\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003e\u003cstrong\u003eDirections:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eTake 1-2 capsules no more than 15 minutes before the consumption of histamine-rich foods, or take as directed by your healthcare practitioner.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCautions:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eConsult your healthcare practitioner before use, especially if you are pregnant or nursing. Keep out of reach of children. Avoid if allergic to pork or any other ingredient. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cvideo width=\"540\" height=\"355\" controls=\"controls\"\u003e\n \u003csource src=\"https:\/\/21431710.fs1.hubspotusercontent-na1.net\/hubfs\/21431710\/Whats%20the%20Difference%20Between%20Hista%20Clear%20and%20Clear%20Histamine%20Scavenger%3F.mp4\" type=\"video\/mp4\"\u003e\n Your browser does not support the video tag.\n \u003c\/source\u003e\u003c\/video\u003e\u003c\/p\u003e"}