Are you struggling with symptoms of an Autoimmune disorder? The stimulation of an immediate immune response may worsen the clinical condition. In the presence of self-antibodies, an immune stimulation may enhance the attack against self-tissue. Therefore, it may be contraindicative to use immune stimulating nutrition in such cases. This makes it difficult to choose a protocol that will both kill a pathogen and not stimulate or utilize your own immune system to do so.
Ingredients
Gamma-tocotrienol: Vitamin E tocotrienols are most effective in preventing lipid oxidation and have been highlighted as a superior antioxidant. (1) They possess potent antioxidant and anti-inflammatory activities and studies show use provides a marked reduction in the severity of histopathological changes observed in autoimmune arthritis. (2)
Resveratrol: Many studies have shown that resveratrol has antioxidant, anti-inflammatory, and neuroprotective properties as it suppresses microglia activation, and promotes Th2 responses by increasing anti-inflammatory cytokines, essential for those with autoimmune disorders. It can also promote neurogenesis, and prevent hippocampal damage. In addition, the antioxidant activity of resveratrol plays an important role in neuronal differentiation through the activation of silent information regulator-1 (SIRT1). (3) Moreover, resveratrol regulates immunity by interfering with immune cell regulation, proinflammatory cytokines' synthesis, and gene expression. (4)
Curcumin (C3 Curcuminoids): Curcumin has a wide range of beneficial properties e.g., anti-inflammatory, anti-oxidant, anti-cancer, anti-proliferative, anti-fungal and anti-microbial. (5) Its anti-inflammatory mechanism is attributed through inhibition of inducible nitric oxide synthase (iNOS), Cycloxygenase-2 (COX-2), inhibition in production of pro-inflammatory cytokines [IL-1, IL-6, IL-8, IL-12, interferon γ (IFN-γ), tumor necrosis factor-α (TNF-α).
Grape Seed Extract: Grape seeds are considered one of the most import- ant sources for phenolic and other compounds that work against biofilm production. (6)
Sodium Alginate (Grifola frondosa and Ganoderma lucidum): Sodium alginate is a soluble dietary fiber extracted from brown seaweed and its solution has been used to support GUT healing, bind toxins in the intestinal tract, and as a hemostatic agent to aid in gastrointestinal bleeding due to gastric ulcers. (7, 8)
N-Acetyl L-Cysteine (NAC): NAC is widely known as a precursor to the antioxidant glutathione as it modulates glutamatergic, neurotrophic, and inflammatory pathways. (9)
Glycine: Glycine acts as precursor for several key metabolites of low molecular weight such as creatine, glutathione, haem, purines, and porphyrins. Supplementation of glycine is effectual in aiding metabolic disorders such as cardiovascular diseases, several inflammatory diseases, obesity, cancers, neurological disorders, and diabetes. (10) Glycine decreases the levels of oxidative stress markers in liver and helps balance glutathione levels leading to reduced oxidative stress. (11)
Phosphatidylcholine: Phosphatidylcholine is the major phospholipid in bile, which is the major route for elimination of cholesterol and toxins from the liver. Bile is also the major route of excretion of trace metals, particularly arsenic, copper, manganese, lead, mercury, selenium, silver, and zinc. (12)
Artichoke (Cynara scolymus): Extremely safe, well-studied nutrient that has antioxidant, choleretic, hepatoprotective, bile-enhancing and lipid-lowering effects. (13, 14, 15, 16, 17)
NOTE: All of the above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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References
1. Shahidi F, de Camargo AC. Tocopherols and Tocotrienols in Common and Emerging Dietary Sources: Occurrence, Applications, and Health Benefits. Int J Mol Sci. 2016;17(10):1745. Published 2016 Oct 20. doi:10.3390/ijms17101745
2. Zainal Z, Rahim AA, Radhakrishnan AK, Chang SK, Khaza'ai H. Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo. Sci Rep. 2019;9(1):16793. Published 2019 Nov 14. doi:10.1038/s41598-019-53424-7
3. Gomes BAQ, Silva JPB, Romeiro CFR, et al. Neuroprotective Mechanisms of Resveratrol in Alzheimer's Disease: Role of SIRT1. Oxid Med Cell Longev. 2018;2018:8152373. Published 2018 Oct 30. doi:10.1155/2018/8152373
4. Malaguarnera L. Influence of Resveratrol on the Immune Response. Nutrients. 2019;11(5):946. Published 2019 Apr 26. doi:10.3390/nu11050946
5. Hewlings SJ, Kalman DS. Curcumin: A Review of Its' Effects on Human Health. Foods. 2017;6(10):92. Published 2017 Oct 22. doi:10.3390/- foods6100092
6. Al-Mousawi, A.H., Al-kaabi, S.J., Albaghdadi, A.J.H. et al. Effect of Black Grape Seed Extract (Vitis vinifera) on Biofilm Formation of Methicillin-Resis- tant Staphylococcus aureus and Staphylococcus haemolyticus. Curr Microbiol (2019) doi:10.1007/s00284-019-01827-0
7. Horibe S, Tanahashi T, Kawauchi S, Mizuno S, Rikitake Y. Preventative Effects of Sodium Alginate on Indomethacin-induced Small-intestinal Injury in Mice. Int J Med Sci. 2016;13(9):653–663. Published 2016 Aug 1. doi:10.7150/ijms.16232
8. Mackie AR, Macierzanka A, Aarak K, et al. Sodium alginate decreases the permeability of intestinal mucus. Food Hydrocoll. 2016;52:749–755. doi:10.1016/j.foodhyd.2015.08.004
9. Bavarsad Shahripour R, Harrigan MR, Alexandrov AV. N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities. Brain Behav. 2014;4(2):108–122. doi:10.1002/brb3.208
10. Razak MA, Begum PS, Viswanath B, Rajagopal S. Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Oxid Med Cell Longev. 2017;2017:1716701. doi:10.1155/2017/1716701
11. El-Hafidi M, Franco M, RamÃrez AR, et al. Glycine Increases Insulin Sensitivity and Glutathione Biosynthesis and Protects against Oxidative Stress in a Model of Sucrose-Induced Insulin Resistance. Oxid Med Cell Longev. 2018;2018:2101562. Published 2018 Feb 21. doi:10.1155/2018/2101562
12. Boyer JL. Bile formation and secretion. Compr Physiol. 2013;3(3):1035–1078. doi:10.1002/cphy.c120027
13. Salem, B et al Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits. Plant Foods Hum Nutr. 2015 Dec;70(4):441-53. doi: 10.1007/s11130-015-0503-8
14. Kirchhoff, R. et al. Increase in choleresis by means of artichoke extract. Results of a randomized placebo-controlled double-blind study. Phytomed- icine 1994; 1: 107.
15. Held C. Artischoke bei Gallenwegsdyskinesien: Workshop “Neue Aspekte zur Therapie mit Chloretika.†Kluvensiek. 1991; 2:9. Cited in Kraft K. Artichoke leaf extract—Recent findings reflecting effects on lipid metabolism, liver and gastrointestinal tracts. Phytomedicine. 1997; 4(4):369-378
16. Rondanelli M. et al Health-promoting properties of artichoke in preventing cardiovascular disease by its lipidic and glycemic-reducing action. Monaldi Arch Chest Dis. 2013 Mar;80(1):17-26.
17. El-Boshy M1et al Studies on the protective effect of the artichoke (Cynara scolymus) leaf extract against cadmium toxicity-induced oxidative stress, hepatorenal damage, and immunosuppressive and hematological disorders in rats. Environ Sci Pollut Res Int. 2017 May;24(13):12372-12383.