The postnatal pancreas responds to hormonal stimulation, for example as triggered by cholecystokinin. The gastrointestinal peptides motilin, cholecystokinin and secretin have been shown to increase pancreatic secretions in preruminant calves. The neonatal pancreas shows a much stronger expression of cytokeratins, as compared to adults.
Lower enzyme production in the adult bovine pancreas is also evidenced by the diminished production of the enzyme rennet, an enzyme that curdles milk, shown to be significantly lower in adult animals, as compared to a higher prevalence in newborn pancreas. Additionally, calf pancreatic enzymes, such as chymotrypsin, elastase, carboxypeptidases and amylase, from milk-fed calves increased in activity after birth until weaning.
The secretory activity of the pancreatic islets has also shown a decline in function with increasing age, as evidenced by fibrosis around the pancreatic islets in aged animals, as compared to islets of younger animals. Amylase output is also markedly higher in younger animals, which was shown to decrease to below 20% in older animals.
Since the early 1980’s, Biotics Research has been at the forefront of glandular production, reflecting its commitment to research and innovation. Glandulars from Biotics Research are prepared strictly from BSE-free countries and collected under USDA inspection. Most Biotics Research glandular products incorporate tissues from newborn calves, harvested specifically for Biotics Research, to ensure quality and to provide a reproducible source of the bovine tissues. Inevitably, in certain cases, adult organs must be used, as in the case of ovarian and orchic tissue, which is unobtainable from very young animals.
Tissues from newborn animals possess high anabolic activity, and have had minimal exposure to environmental stressors. Atrophy, fatty infiltration, tissue degeneration and the accumulation of oxidative waste products (lipofuscin) are not observed in tissues from newborn calves.
In contrast, the usual sources of most commercially available glandular products are glands and organs collected from different cattle carcasses of various ages, obtained from numerous slaughterhouses. Tissues are pooled, and processed with the resulting powdered preparation sold to manufacturers. As a result, physicians and consumers using such products have little or no detailed knowledge of their sources, such as the ages or health of animals harvested, or the degree of exposure to environmental stressors.