Brain & Hypothalamus/Pituitary Axis
Abnormalities of the hypothalamus-pituitary-adrenal axis regulation are common with aging. For example, regions of the brain showed major deficits in cell signaling in older animals.13 In the brain, accumulation of oxidized protein corresponds to a loss of key enzyme activities.
Since the early 1980’s, Biotics Research has been at the forefront of glandular production, reflecting its commitment to research and innovation. Glandulars from Biotics Research are prepared strictly from BSE-free countries and collected under USDA inspection. Most Biotics Research glandular products incorporate tissues from newborn calves, harvested specifically for Biotics Research, to ensure quality and to provide a reproducible source of the bovine tissues. Inevitably, in certain cases, adult organs must be used, as in the case of ovarian and orchic tissue, which is unobtainable from very young animals.
Tissues from newborn animals possess high anabolic activity, and have had minimal exposure to environmental stressors. Atrophy, fatty infiltration, tissue degeneration and the accumulation of oxidative waste products (lipofuscin) are not observed in tissues from newborn calves.
In contrast, the usual sources of most commercially available glandular products are glands and organs collected from different cattle carcasses of various ages, obtained from numerous slaughterhouses. Tissues are pooled, and processed with the resulting powdered preparation sold to manufacturers. As a result, physicians and consumers using such products have little or no detailed knowledge of their sources, such as the ages or health of animals harvested, or the degree of exposure to environmental stressors.
The development of Biotics Research glandular products was the offshoot of original research performed by our CDC-licensed, genetics-toxicology testing laboratory in the 1980’s. When Biotics Research developed the first mobile laboratory to respond to environmental contamination requiring a rapid assessment of possible chromosomal damage, fetal calf serum was required to culture human cells. When the supply of fetal calf serum became limited due to increased demand by biotech firms, Biotics Research had to examine newborn calves as an alternative source. Serum isolated from these animals, tested at the National Institutes of Health, matched the quality of fetal calf serum. The use of newborn calves as a source of high quality glandular tissues resulted from this research.