Ortho-Molecular

CLINICAL APPLICATIONS Promotes Healthy Collagen Formation to Maintain Healthy Blood Vessels Supports Connective Tissues Maintains Normal Inflammatory Balance Boosts Immune System Function OVERVIEW While most mammals can synthesize vitamin C, humans lack the enzyme required to synthesize vitamin C from glucose and, must obtain the vitamin from their diet. C-Flav is a formula that combines vitamin C with various bioflavonoids to mirror the way vitamin C is found in nature. Suggested Use: 1 or more capsules per day or as recommended by your health care professional. INGREDIENT BENEFITS Immune Support Vitamin C has long been recognized for its role in supporting the immune system, specifically T cells, which absorb and concentrate vitamin C. Inflammatory Balance Vitamin C plays a key role in maintaining normal inflammatory balance. Bioflavonoids Bioflavonoids are a group of plant pigments that provide the colors of many fruits and flowers. Flavonoid intake is associated with cardiovascular health and microbial balance.

CLINICAL APPLICATIONS Promotes Healthy Microbial Balance Helps Maintain Gastro-Intestinal Comfort Provides Nutrients that Increase Antioxidant Protection Enhances Immune Function OVERVIEW Gastrointestinal health is directly affected by factors like poor diet and a stressful lifestyle. The prevalence of refined sugars and carbohydrates and lack of fiber in Western diets have been directly linked to changes in the intestinal and colonic environments. Since more than 70% of the body’s immune system resides in the gut, establishing a healthy microbial balance is critical in reducing immune challenges and maintaining inflammatory balance. Candicid Forte provides a blend of nutrients, potent botanicals and essential oils to promote healthy microbial balance and immune support. Formulated with the goal of building a healthy gastrointestinal (GI) flora, Candicid Forte includes biotin, a nutrient that inhibits yeast from converting into the more aggressive fungal form. In addition, sodium caprylate is included to disrupt the metabolism of Candida and create a hostile environment for colonization. It also includes potent botanicals, such as berberine HCl, Pau d’Arco, oregano, rosemary, cinnamon and ginger, to sooth the GI tract, provide potent antioxidant support, and ensure microbial balance. Suggested Use: 2 capsules three times per day or as recommended by your health care professional INGREDIENT BENEFITS Biotin Biotin is a water-soluble vitamin and cofactor for carboxylases; the nutrient affects several key systemic functions such as tissue growth, development, immunity and metabolism. Deficiencies in biotin have also been linked with mild immune impairment. The role that biotin can play in the GI tract is primarily based on its ability to establish microflora balance by preventing yeast, especially Candida albicans, from converting to its more invasive fungal form. In the presence of biotin, yeast is unable to change into the mycelium form. Oregano Phytonutrients from oregano, such as rosmarinic acid and quercetin, have been shown to play a role in supporting antioxidant mechanisms and healthy microbial balance in the body. In addition, the high ORAC (oxygen radical absorbance capacity), on a scale developed by scientists at the National Institute of Aging) value of oregano, indicates its significant antioxidant-scavenging capacity to combat free radicals that cause oxidative stress. Oregano oil also contains two naturally occurring microbial balancing agents named carvacrol and thymol. Research suggests that these compounds relieve GI dysbiosis and promote a healthy GI microflora. Pau d’Arco The inner portion of the Pau d’Arco bark has been used by Native Americans for thousands of years to support intestinal microbial health. The herb has been shown to be effective in promoting healthy intestinal flora and is recommended by herbalists for a wide variety of GI challenges. Studies have shown that Pau d’Arco may also balance musculoskeletal inflammation and in vitro studies have shown fractions from Pau d’Arco support microbial balance. Sodium Caprylate Sodium Caprylate is the stable sodium salt of caprylic acid, a fatty acid found in coconuts. In vitro studies show that sodium caprylate inhibits aerobic and anaerobic growth, provokes loss of cytoplasm organization and organelles, inhibits budding, triggers potassium loss, and is destructive to the cellular integrity of Candida albicans. Caprylic acid has been shown to contribute to microbial balance. Berberine HCl An alkaloid extracted from plant roots, berberine has been found to express strong microbe balancing activity in vitro, and was found to be the best of four agents studied in inhibition of Candida albicans’ adherence to HT-29 epithelial cells. Berberine was also found to inhibit SAP (secreted aspartyl proteinases) activity by 70.2% +/-6%, a marker of yeast conversion to the aggressive fungal form. In one in vitro study, mice given 1 mg/kg body weight of berberine had a potent effect on microbial balance, and displayed synergistic effects with fungal balancing agents. Rosemary The essential oil of rosemary has been shown to exhibit broad-spectrum microbial balancing effects. The oil was analyzed in vitro for its microbial balancing and antioxidant activities and was found to have strong activity. Rosemary extract has also been shown to decrease oxidative stress in various tissues. Cinnamon Bark Extract In an in vitro study looking at different strains of microbes, including MRSA and Candida species, the essential oil of cinnamon showed consistent ability to maintain microbial balance. In vitro research has shown that cinnamon extract causes a change in cell morphology, destruction of organelles and cellular burst when microbes are exposed to the essential oils of cinnamon.

CLINICAL APPLICATIONS Supports Cardiovascular and Neurologic Health Supports Homocysteine Balance Supports Healthy Arterial Function Maintains Normal Inflammatory Balance OVERVIEW Methylation is a vitamin-requiring biochemical process in the body that is critical for maintaining mental and physical health. Methylation helps convert the problematic amino acid metabolite homocysteine into the amino acids methionine and cysteine. Consistent recycling of homocysteine is vital for supporting cardiovascular health. Proper methylation can be inhibited by nutrient deficiencies, especially of folic acid, B6 and B12. Cardio B contains targeted amounts of folic acid, B12, B6 and betaine (trimethylglycine) to support methylation pathways in the body. Suggested Use: 1 or more capsules per day or as recommended by your health care professional INGREDIENT BENEFITS Folate Adequate folate status is critical for maintaining optimal methylation, red blood cell balance, DNA and RNA synthesis and healthy cell division and replication. Folic acid is converted into its metabolically active form, 5-MTHF, by the enzyme methylenetetrahydrofolate reductase (5-MTHFR). 5-MTHF donates its methyl group to vitamin B12 (cobalamin), forming methylcobalamin. Methylcobalamin helps convert the problematic amino acid metabolite homocysteine into the amino acid methionine. B12 Vitamin B12 (methylcobalamin) works along with folic acid in many body processes, including the synthesis of DNA, red blood cells and supporting health of the myelin sheath, the insulating exterior that surrounds nerve cells. B12 is found primarily in animal foods. Vegetarians and the elderly are at highest risk for B12 deficiency. B12 is considered by many to be a vital nutrient required to balance homocysteine levels. Methylcobalamin is the biologically active form of B12 and supports up-regulation of methylation pathways. B6 Vitamin B6 (pyridoxine) is a B vitamin that is required for more than 60 different enzymatic reactions that occur in the body. Vitamin B6 works along with folic acid and B12 for in the recycling of homocysteine. B6 also supports a healthy cardiovascular system by promoting healthy platelet aggregation and aids in maintaining healthy blood pressure. Vitamin B6 is required for the activation of lysyl oxidase, an enzyme responsible for the cross-linking of collagen, and elastin, which is crucial for maintaining normal circulation and arterial function. Trimethylglycine (Betaine) Trimethylglycine (betaine) functions in the body as a unique methyl donor, supporting liver function and detoxification pathways and the conversion of homocysteine to methionine. Trimethylglycine also works alongside B6, B12 and folic acid in supporting homocysteine balance.

Cardio MET Pack provides a complete cardiometabolic protocol, combining three comprehensive supplemental formulas in convenient, easy-to-take packets. Clinical Applications Provides Essential Fatty Acids Supports Healthy Metabolic Function and Maintains Normal Inflammatory Balance Supports Healthy Lipid Balance and Blood Glucose Levels Already Within the Normal Range It is estimated that one-third to one-half of Americans have cardiovascular and metabolic health concerns, and this number shows no sign of slowing down. Not only does this reality put a significant burden on the metabolic health of Americans, but also on the health care system itself. Over the past few decades there have been many advancements in our understanding of metabolic health and how nutrients support proper metabolic function. Further, it is clear that no single nutrient alone is sufficient to maintain metabolic health for the majority of patients. Cardio MET Pack solves this problem by delivering a supplemental protocol combining the most researched and effective combination of nutrients for cardiovascular and metabolic health, in a convenient daily pack. Suggested Use: 1 packet per day or as recommended by your health care professional.

This may be fulfilled by a product that this manufacturer Private Labels for us Clear Estro DIM Pro / CDG EstroDIM is a targeted supplement that combines the synergistic benefits of the cruciferous vegetable metabolites Indole-3-carbinol (I3C) and diindolylmethane (DIM) to support proper estrogen metabolism. Formulating I3C and DIM together creates the ideal combination of beneficial metabolites to support estrogen balance and breast and prostate health. We Private Label Orthomolecular's CDG EstroDIM as our Clear Estro DIM Pro. By purchasing this product you are agreeing to receive it as our private labeled Clear Estro DIM Pro. It is the exact same product the Orthomolecular packages and labels for us. The Health Benefits of Cruciferous Vegetable Metabolites† Many of the health benefits derived from eating cruciferous vegetables (cabbage, brussels sprouts, broccoli, etc.), especially those that may be beneficial for breast and prostate health, are thought to be derived from the group of secondary metabolites known as glucosinolates. When these vegetables are cut, crushed or chewed the enzyme myrosinase (released from the cells) hydrolyses these glucosinolates into other compounds. For instance, glucosinolates from broccoli and brussel sprouts readily convert into I3C when consumed. I3C can then be further converted via stomach acid into other health promoting compounds, including DIM. These compounds are generally thought to be responsible for the various cellular activities that lead to hormone health. Overview Estrogen collectively refers to the female hormones estradiol, estrone and estriol. Hormones have important functions in every area of the body. They are chemical messengers that interact with cells all over the body (especially tissues that are more sensitive to them, including breast and prostate tissues). The most important message they deliver to cells is to grow, divide and multiply. For this reason, hormones are critically important in human development and tissue repair. Supporting proper estrogen synthesis, metabolism and detoxification is essential for proper hormonal balance. The means in which estrogen is metabolized can result in different metabolites, each with individual biological activity. By keeping hormones in balance and ensuring the body is able to process hormones properly, cruciferous vegetable metabolites (such as I3C and DIM) work together to reduce hormone overload and maintain cellular health. Current data on I3C and DIM suggests that these phytonutrients have strong potential for supporting breast, cervical, uterine and prostate health.1-4 Together, I3C and DIM promote the creation of the favorable and protective 2-hydroxyestrone (2-OHE) metabolite versus production of 4-hydroxyestrone (4-OHE) and 16-alpha-hydroxyestrone (16-alphaOHE), metabolites which can overstimulate cells and create free radicals that cause DNA damage.5 The influence of I3C and DIM on estrogen metabolism creates a more desirable ratio of 2-OHE to 16-alpha-OHE. This assessment of 2:16-alpha- OHE ratio has been used to evaluate breast health. With this in mind, CDG EstroDIM includes targeted doses of both I3C and DIM in a two capsule per day dosing to make daily balancing of hormones easy and convenient. I3C† I3C (indole-3-carbinol) is a naturally occurring compound found in numerous cruciferous vegetables, such as broccoli, cauliflower, kale and cabbage. Following ingestion of I3C, the body converts it to several different metabolites, one of which is diindolylmethane (DIM). Both of these compounds, as well as many other I3C metabolites, have been shown to impact metabolic shifts and cellular activities for improved health outcomes. I3C has also been shown to temper estrogen signals by competing for binding sites and inhibiting the activity of estrogen receptors.6-15 A study published in the Journal of Nutrition unveiled evidence that I3C supports healthy cellular function related to estrogen metabolism.16 DIM† Diindolylmethane (DIM) is a phytonutrient and plant indole also found in cruciferous vegetables with potential for enhancing proliferation of healthy cells and cellular activities. As a dimer (formed chemical structure of two substances) of indole-3-carbinol, DIM promotes beneficial estrogen metabolism in both sexes supporting the formation of healthy estrogen metabolites and enhancing the potential for greater antioxidant activity.17-19 Calcium D-Glucarate † Calcium D-Glucarate is the supplemental calcium salt form of D-glucaric acid, a substance produced naturally in the body and obtained through consumption of certain fruits and vegetables. Calcium D-glucarate has been extensively studied and has been shown to inhibit beta-glucuronidase, an enzyme found in certain bacteria that reside in the gut. This activity supports the body’s ability to detoxify estrogens, foreign molecules and fat-soluble toxins.20-23 Directions 2 capsules per day or as recommended by your health care professional. Does Not Contain Wheat, gluten, corn, yeast, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners or preservatives. Cautions Do not consume this product if you are pregnant or nursing.

CLINICAL APPLICATIONS Formulated Specifically for Patients with Occasional Sleeplessness Promotes Calmness and Relaxation Supports Normal, Uninterrupted Sleep Provides Comprehensive Neurotransmitter Support OVERVIEW Sleep is the body’s way of metabolically and psychologically resetting itself. The body’s circadian rhythm is regulated by an internal biological clock with an approximate 24-hour cycle. In order to maintain restorative sleep, it is crucial that the brain has optimal levels of serotonin and gamma-aminobutyric acid (GABA), the relaxing and sleep-regulating neurotransmitters, as well as the sleep-regulating hormone melatonin. The synergistic ingredients in Cerenity PM, including 5-HTP, PharmaGABA®, and taurine, boost levels of the neurotransmitters and hormones that promote relaxation prior to bedtime and increase the deep, restorative stages of sleep. Suggested Use: 4 capsules taken one to two hours before bedtime or as recommended by your health care professional INGREDIENT BENEFITS 5-HTP The sleep-regulating hormone melatonin requires the essential amino acid, L-tryptophan for conversion. A deficiency of L-tryptophan in the diet can lead to low serotonin and melatonin levels, which can contribute to sleep challenges. L-tryptophan is converted into the amino acid intermediate 5-hydroxytryptophan (5-HTP), which is then converted directly into serotonin, followed by melatonin conversion. PharmaGABA® Gamma-amino butyric acid (GABA) is one of the major inhibitory neurotransmitters in the brain. GABA provides a calming effect and plays a direct role in activating the sleep cycle in the evening. Most commercially available forms of GABA utilize synthetically-produced GABA, manufactured from pyrrolidinone, a compound not allowed for use in Japan. Cerenity PM includes a patented, naturally-sourced, non-synthetic form of GABA called PharmaGABA®. In a study utilizing 100 mg of PharmaGABA®, supplemented before bedtime, PharmaGABA® was shown to reduce sleep latency by 20%, while increasing time spent in a deep sleep by 20%. Phosphatidylserine Phosphatidylserine (PS) is a phospholipid found in high concentrations in the brain. Phosphatidylserine has been shown to play a role in regulating cortisol excretion. Elevated levels of cortisol throughout the night can contribute to frequent waking. When taken in the evening, PS can help reduce cortisol excretion from the body’s stress response system, the hypothalamic-pituitaryadrenal (HPA) axis, in order to promote a healthy sleep cycle. Taurine Taurine is an amino acid that is found abundantly in the brain and has neuroprotective properties. Taurine promotes inhibitory neurotransmission by activating GABA receptors. Taurine also supports inhibitory neurotransmission by activating glycine receptors in the brain. Mineral Blend Calcium and magnesium are two minerals that play a major role in supporting a healthy sleep cycle. Magnesium (Mg) calms the nervous system and has been shown to play a role in the regulation of the HPA axis. Magnesium promotes relaxation by decreasing the activity of glutamate, the primary excitatory (stimulating) neurotransmitter in the brain. Calcium ions are a critical requirement in the synthesis of melatonin. The combination of 5-HTP and calcium in Cerenity PM provides a significant and natural boost to melatonin levels, aiding in the conversion and activation of this crucial sleep hormone.

CitraNOX is formulated specifically to maintain healthy blood pressure levels by enhancing endothelial cell and arterial function. Using a combination of high- dose L-citrulline, quercetin and grape seed extract, CitraNOX delivers full-spectrum support to help maintain normal inflammatory balance, arterial elasticity, optimal nitric oxide levels, and blood flow. CitraNOX provides a powerful formula for those seeking to optimize several mechanisms of cardiovascular health. Overview Stress placed on coronary arteries as a result of normal cardiac function is an expected part of the aging process. This stress can lead to disruptions in arterial function, proliferation of vascular smooth muscle, decreases in circulating nitric oxide (NO) levels, and eventually vasocontraction of key coronary arteries.1,2 CitraNOX provides a blend of targeted nutrients designed to help dampen this stress by maintaining normal inflammatory balance, balancing NO levels, maintaining smooth muscle integrity, and optimizing vasodilation of key coronary arteries. L-Citrulline† L-citrulline is one of three dietary amino acids in the urea cycle responsible for converting ammonia into urea as well as for the production of NO, an important cellular signaling molecule. In this process, L-citrulline is the natural precursor of L-arginine, the substrate used by endothelial nitric oxide synthase (eNOS) to produce NO. As a signaling molecule, NO has been shown to have a very powerful effect on vasodilation and blood flow.3-5 Because of this, optimizing circulating NO levels has long been a target of aerobic and anaerobic athletes. In fact, numerous clinical trials have been conducted showing that L-citrulline and L-arginine supplementation have a profound effect on exercise performance and power output.6-10 The benefits of circulating NO levels stretch far beyond exercise performance. As a vasodilator, NO improves arterial elasticity, decreases platelet adhesion, scavenges free radicals, and prevents oxidation of LDL cholesterol.11-13 Studies show low levels of NO are associated with endothelial cell dysfunction, vasoconstriction, and blood flow challenges.13-15 Unfortunately, supplemental L-arginine has a small, transient effect, with no long-term benefit on circulating NO levels, because liver metabolism restricts excess arginine from the blood to avoid long-term physiological consequences.14,16,17 However, recent research shows that supplementing L-citrulline bypasses liver metabolism, thus making it more bioavailable in the blood stream and allowing it to significantly impact circulating NO levels.18 In a direct comparison, a recent study showed 3,000 mg of L-citrulline supplementation increased circulating NO levels 1.6-fold higher than 3,200 mg of L-arginine.19 Another direct comparison study showed L-citrulline supplementation significantly sustained peak plasma NO levels for upwards of four hours, and NO levels in the L-arginine group begin to decline at 1.5 hours.20 Quercetin Dihydrate† A flavonoid found in a variety of botanicals, vegetables and fruits, quercetin is a potent antioxidant that inhibits inducible ICAM-1 expression, an important pathway for maintaining normal inflammatory balance.21 Quercetin has been shown to support normal inflammatory balance by directly inhibiting the activity of NFkB, similar to turmeric.22 Quercetin is known for its ability to improve endothelial cell dysfunction by maintaining normal inflammatory balance in specific pathways.23 MegaNatural® BP Grape Seed Extract† MegaNatural® BP is a premium grape seed extract made in California from a special seed blend extracted with water from a variety of white wine grape seeds. Grapes and grape products contain phenolic compounds found to have health-promoting properties, particularly in cardiovascular wellness.24 Grape seed extract has a high concentration of phenolic compounds, which have been found to support healthy arterial dilation and blood flow. These polyphenols have been shown to activate NOS, the enzyme that facilitates NO production.25 A study examining the effects of MegaNatural® BP grape seed extract in 27 volunteers found that after four weeks of supplementation with either 150 mg or 300 mg, the participants were able to maintain healthy blood pressure levels.26 The participants taking 300 mg also had a significant reduction in oxidized low-density lipoprotein when compared to placebo. Directions 4 capsules per day or as recommended by your health care professional. Does Not Contain Gluten, corn, yeast, artificial colors and flavors. Cautions If you are pregnant or nursing, consult your health care professional before taking this product.

CLINICAL APPLICATIONS Multidimensional Support for Cardiovascular Health Enhances Cell Signaling for Efficient ATP Production Supports Blood Sugar Balance Already Within Normal Levels Maintains Healthy Cholesterol Levels OVERVIEW Clinical research shows that maintaining optimal cardiovascular health should address multiple metabolic factors. CM Core, a formula backed by extensive clinical research, is designed to address several factors associated with ideal cardiometabolic health. The powerful combination of berberine and alpha lipoic acid (ALA) helps maintain heart function, metabolism, antioxidant status, and lipid and glucose levels. CM Core provides a powerful formula for those seeking to optimize the multiple mechanisms of cardiovascular and metabolic health. Suggested Use: 3 capsules per day or as recommended by your health care professional INGREDIENT BENEFITS Berberine Berberine is a plant extract that has been used in Chinese and Ayurvedic medicine for over 2,500 years for its broad range of health-promoting properties. Berberine can be found in the roots and stems of plants such as Hydastatis canadensis (goldenseal), Coptis chinensis (goldenthread), Berberis aquifolium(Oregon grape) and Berberis vulgaris (barberry). Clinical trials have demonstrated that berberine administration supports cardiovascular health in a number of synergistic ways. Alpha Lipoic Acid (ALA) Alpha lipoic acid (ALA) is a nutrient required for cellular metabolism, specifically the breakdown of carbohydrates and fatty acids. ALA has been shown to support blood sugar balance already within normal levels by activating AMPK, a major regulator of cellular energy.

CLINICAL APPLICATIONS Maintains Healthy Joint Function for Normal Mobility and Lubrication Provides Precursors for Generation of Cartilage, Tendons, Ligaments, Fascia and Skin Promotes a Healthy Joint Environment by Supporting Normal Activity of Cytokines and Catabolic Enzymes OVERVIEW Collagen Factors provides targeted precursors and cofactors known to be involved in the biochemical processes that support healthy connective tissue in the skin, tendons, ligaments, cartilage, joints and bone extracellular matrix. This formulation contains patented hyaluronic acid, MSM, free-form amino acids, key minerals and vitamin C. Suggested Use:2 capsules per day or as recommended by your health care professional. INGREDIENT BENEFITS Hyaluronic Acid ExtractMobilee® is a patented, high-molecular-weight hyaluronic acid (HA), which enhances the viscoelastic, lubricating properties of synovial fluid. In addition, it contains collagen and other glycosaminoglycans (GAGs) to enhance skin and joint health. Hyaluronic acid also plays a role in the biophysical, biochemical and cell regulation processes in joint synovial tissues. Scientific evidence shows that Mobilee® supports chondrocytes and synovial cells function, and is two to four times more active than fermented sources of HA in nourishing and supporting the health of synovial fluid. The latest clinical research includes HA in proactive and maintenance approaches to joint care that supports normal range-of-motion. Research suggests that Mobilee® supports the quality of synovial fluid by positively influencing synovial HA concentration, and by reducing the expression of degradative factors in synovial fluid. Specific PrecursorsCollagen is comprised of and formed from the amino acids proline and lysine. Lysine is an essential amino acid the body relies on adequate dietary intake for its involvement in the synthesis of connective tissues. Proline is well-known for its involvement in the triple helix of collagen—it is regularly spaced with glycine in the amino acid sequence of collagen fiber, which together comprise about 50% of total collagen sequencing. Proline contributes to not only collagen formation, but muscle, tendons and skin. Lysine helps support the linking and stabilization of collagen, and contributes to the collagen matrix formation of veins, arteries and capillaries. During procollagen synthesis, both proline and lysine are hydroxylated to hydroxyproline and hydroxylysine, a reaction requiring vitamin C as a cofactor. Inadequate levels of vitamin C can impact this reaction, resulting in incomplete formation of the helical structure, in which leads to a delicate and easily destroyed structure. Vitamin C is combined with two amino acids—lysine and proline—to form procollagen. Procollagen is then used to manufacture one of several types of collagen found in different tissues throughout the body. Targeted CofactorsZinc is an essential trace mineral that supports DNA synthesis, cell division, cell membrane structure, immune function, and protein synthesis. Requirements are highest when the body’s repair system is most active. MSM is responsible for the flexible disulfide bonds between cells, including those that make up connective tissue and the skin. It blocks undesirable chemical and physical cross-linking of collagen and preserves connective tissue pliancy, which is crucial for supporting healthy collagen. MSM has been shown to significantly increase plasma glutathione levels, an additional benefit in maintaining collagen’s defensive mechanisms against oxidative stress. Multiple clinical studies also show that MSM, in combination with other joint health ingredients, supports tendon and joint health. Manganese assists the growth and development of normal bone and the synthesis of cartilage. Manganese is also a structural component of antioxidant enzymes, and aids in amino acid production. During the tissue synthesis process, which requires an increased production of collagen, manganese is required for the activation of prolidase, an enzyme that functions to provide the amino acid proline, for collagen formation in human skin cells. Nutritional co-factors required for tissue regeneration include zinc, vitamin C and amino acids. Inadequacy of these nutrients impacts endogenous collagen production and connective tissue synthesis.

CollaGEN is formulated to nutritionally support cartilage, tendons, ligaments, fascia and skin. Clinical Applications Protects and Promotes Connective Tissue Biosynthesis Supports the Body’s Processes of Cartilage, Tendon, Ligament and Fascia Self-Repair Supports Joint Lubrication, Joint Cushioning, and Normal Connective Tissue Inflammatory Response Supports Normal Rejuvenation of Healthy Hair, Skin and Nails Over time lifestyle factors can cause reduced elasticity in cartilage, tendons, ligaments and skin. This not only leads to wrinkles and decreased dermal matrix, but to soft tissue and joint discomfort. FORTIGEL® has been shown in human studies to stimulate collagen regeneration, type II collagen and aggrecan, which all help to maintain healthy connective tissue. Most therapies simply block joint pain and connective tissue discomfort, and in doing so inhibit the regeneration and elongation of specific precursors, such as polysaccharides, and deplete nutrients such as vitamin C and magnesium that maintain joint and connective tissue health. FORTIGEL®, TendoActive® and Mobilee® protect and preserve cartilage, tendons, ligaments, intervertebral discs, and fascia. These patented ingredients support the natural healing process and maintain the structure of connective tissues. Suggested Use: 1 packet (7.6 grams) in 8 oz of water or the beverage of your choice per day or as recommended by your health care professional. Can also be added to food and baking products.