Complete sleep management with neurotransmitter, cytokine, and histamine support*

The importance of healthy sleep for overall health and well-being cannot be overstated. Unfortunately, achieving quality sleep is a challenge for many people. Common biological contributors to poor sleep can include physical discomfort, stress, anxiety, high histamine levels, and low levels of sleep-promoting neurotransmitters, such as gamma-aminobutyric acid (GABA).[1]

A multifaceted approach is needed to support falling asleep faster, staying asleep longer, and achieving higher quality, more restful sleep. Circadian PM™ utilizes a blend of 10 ingredients, promoting multiple mechanisms of action to nurture healthy sleep.

Mechanisms of Action*

• Calms the central nervous system and promotes sleep initiation by:
  • Increasing GABA, the primary inhibitory central nervous system neurotransmitter*
  • Decreasing breakdown of GABA and its binding capacity *
  • Stimulating GABA receptors*
• Promotes undisrupted sleep by supporting healthy serotonin levels, leading to increased REM sleep*
• Reduces wakefulness by supporting healthy histamine levels in the brain*
• Supports a healthy response to anxiety, promoting better sleep*
• Promotes normal cytokine function to soothe physical discomfort and support neural cytokine levels*

Circadian PM™ features PharmaGABA®, the natural form of GABA, made through a natural fermentation process.  This results in a superior form of GABA  vs other synthetic options. Synthetic forms of GABA are less bio-available, as their molecular size is too large to pass the blood-brain barrier. PharmaGABA® is easily absorbed and binds to GABA receptors in the peripheral nervous system, activating the parasympathetic nervous system. This activation of the parasympathetic nervous system by PharmaGABA® is measurable within 5 to 30 minutes after ingestion .*

The unique blend of herbs, nutrients, and amino acids make Circadian PM™ a must-have formulation for patients dealing with sleep challenges and those who want to improve the quality of their sleep utilizing natural methods.