Conners Clinic - Dr. Kevin Conners' Trusted Nutrition and Supplements

NEW bottle, NEW look, BETTER formulation Conners Clinic Originals Curcu Clear is a highly bioavailable curcuminoid formulation (BCM-95) containing three bioactive, extensively researched curcuminoids. Curcumin is derived from turmeric (Curcuma longa), which is used both medicinally and as a spice. Curcumin supports healthy metabolism, cellular function, and healthy cardiovascular and neurological functions. It also supports a healthy response to oxidative stress and a normal inflammatory response within the body.* BCM-95® Curcu Clear Complex Provides Antioxidant and Cell-Protective Activity* Supports Joint Health and Helps Relieve Minor Pain Associated With Physical Activity* Supports the Health of Organs and Systems by Modulating the Production of Cytokines and Other Signaling Molecules* Supports The Body’s Efforts to Promote Healthy Cell Growth and Inhibit Unhealthy Cell Growth in Certain Cell Lines* Supports Brain/Neuronal Health and a Healthy Mood* Supports a Healthy Microbial Environment*   Curcu Clear - features BCM-95 - a 100% pure turmeric extract standardized to curcumin, demethoxycurcumin, bisdemethoxycurcumin, and essential oils of turmeric rhizome. This natural composition optimizes bioavailability and reflects true turmeric identity to deliver optimal health benefits. BCM-95 has been extensively studied and shows broad efficacy without the use of phospholipids, excipients, additives, carriers, nanotechnology, or bioenhancers.*   NOTE: All of the above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Curcum-Evail  Designs for Health

Conners Originals Apop-E 300 is a unique tocopherol-free, tocotrienols-only product, featuring tocotrienols sourced from the annatto tree. Annatto is the richest known source of tocotrienols, containing 100% tocotrienols (90% delta and 10% gamma isomers), with no tocopherols.Commercial vitamin E supplements are typically rich in tocopherols and low or absent in tocotrienols; however, tocotrienol fractions have unique beneficial effects across a variety of tissues that make them desirable for supporting many aspects of health. Research indicates that tocopherols—especially alpha-tocopherol—may interfere with key therapeutic effects of tocotrienols, so it may be best to dose tocotrienols alone, without tocopherols. Vitamin E is not a single nutrient, but rather a complex consisting of 4 tocopherols and 4 tocotrienols. Each of these components has a different molecular weight and slightly different chemical structure, which impart distinct properties that influence their biochemical functions. Apop-E 300 features DeltaGold®, a patented annatto tocotrienol formula produced in the US by American River Manufacturing.  Ingredients:  Vitamin E Isomers   Made with non-GMO ingredients.   NOTE: All of the above statements have not been evaluated by the Food and Drug Administration. This and any product(s) discussed are not intended to diagnose, treat, cure, or prevent any disease.

Special - save $5 per bottle! NEW, IMPROVED FORMULA (same low price) - now with Vitamin A - a HUGE synergist in the immune system's fight against invaders!!!! Clear CV  is a balanced blend of flavonoids and crucial vitamins and minerals that provide safe, long-term immune support for all populations without overstimulating the immune system. Clear CV is a targeted blend of nutrients designed to provide a broad-spectrum support to the body’s immune reserves. The formula includes quercetin, a powerful bioflavonoid that aids in supporting the immune system. Vitamin C and N-acetyl cysteine are potent antioxidants that promote respiratory function and support the function of quercetin. Vitamin D and zinc are important micronutrients needed to create a robust immune reserve. This powerful combination works to promote healthy respiratory and immune function. Vitamin D3 It has been shown that low vitamin D levels have immunologic implications with a significant decrease in immune function, affecting respiratory health.11,12,17 This is most likely because the vitamin D receptor is expressed by several immune cells including monocytes, macrophages, dendritic cells, B and T cells.18 Supplementation with vitamin D has been shown to modulate NK cell activity to promote a healthy innate immune response.15,19 Along with these immune-supporting benefits, vitamin D has also been shown to support the respiratory system and epithelial tight junction integrity.15,19,20,21 Zinc Zinc is essential for maintaining immune system integrity and healthy immune development.12,13,14 Supplementation with zinc supports key immune functions such as natural killer cell activity and phagocytosis by macrophages and neutrophils.15 Furthermore, studies show that zinc can directly support the body during immune system challenges and can help support healthy respiratory function.15,16 Vitamin C Vitamin C is a potent antioxidant that has been studied for many years for its immune-supporting effects. Through its antioxidant functions, vitamin C has been shown to protect important immune cells from oxidative damage.5 Data shows vitamin C is heavily concentrated in macrophages, supports lymphocyte activity, modulates cytokine release, improves endothelial function, restores mitochondrial function, and can directly support a challenged immune system.3 Of particular interest, vitamin C has been shown to recycle oxidized quercetin back to its parent compound, which supports a robust immune response while increasing the efficacy of quercetin.3,6 Quercetin Quercetin is best known for its antioxidant activity in scavenging free radicals. Additionally, quercetin helps balance the level of cytokines and improve T-lymphocyte balance. Several mechanism studies highlight quercetin’s ability to provide immune system support while also stimulating the ciliary beat frequency of the nasal epithelium, aiding the excretion of respiratory mucus.1,2,3 Quercetin has been shown to block the mechanisms by which microbes enter the host cells and replicate within the body.3 Additionally, a human clinical trial found quercetin supplementation supported healthy respiratory function following a stressor (i.e., intense bout of exercise), compared to placebo.4 N-Acetyl Cysteine (NAC) NAC is the precursor of the master antioxidant, glutathione. NAC has been shown to support mucus clearance and normal respiratory function, through its ability to cleave disulfide bonds in mucus.7,8 NAC is found to raise glutathione levels, which is important to protect the biologic activity and safe metabolism of quercetin.3,9 Along with protecting the activity of quercetin, NAC supports all detoxification pathways and helps maintain immune balance by supporting glutathione levels.10,11 Vitamin A Vitamin A stimulates the production and activity of white blood cells (antiviral and anti-tumor cells); Maintains and strengthens epithelial tissues and mucous membranes — the body's first line of defense against pathogens. We NOW added Vitamin A to our Clear CV NOTE: All of the above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.  Directions 2 capsules per day or as recommended by your health care professional.  Learn more about Clear CV here >> ConnersClinic.com/blog There are NO: Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives. Studies on COVID-19 and Nutrition** US National Library of Medicine | National Institutes of Health: N-Acetylcysteine to Combat COVID-19: An Evidence Review US National Library of Medicine | National Institutes of Health: The prophylaxis and treatment potential of supplements for COVID-19 US National Library of Medicine | National Institutes of Health: Quercetin, Inflammation and Immunity FLCCC Alliance iMASK+: Preventions & Early Outpatient Treatment Protocol for COVID-19 References  1. Wu W, Li R, Li X, et al. Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry. Viruses. 2015;8(1). 2. Mehrbod P, Hudy D, Shyntum D, Markowski J, Łos MJ, Ghavami S. Quercetin as a Natural Therapeutic Candidate for the Treatment of Influenza Virus. Biomolecules. 2020;11(1). 3. Colunga Biancatelli RML, Berrill M, Catravas JD, Marik PE. Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19). Frontiers in immunology. 2020;11:1451. 4. Nieman DC, Henson DA, Gross SJ, et al. Quercetin reduces illness but not immune perturbations after intensive exercise. Med Sci Sports Exerc. 2007;39(9):1561-1569. 5. Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017;9(11). 6. Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. European journal of pharmacology. 2008;585(2-3):325-337. 7. De Rosa SC, Zaretsky MD, Dubs JG, et al. N-acetylcysteine replenishes glutathione in HIV infection. European journal of clinical investigation. 2000;30(10):915-929. 8. Aldini G, Altomare A, Baron G, et al. N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radic Res. 2018;52(7):751-762. 9. Rushworth GF, Megson IL. Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits. Pharmacology therapeutics. 2014;141(2):150-159. 10. Grandjean EM, Berthet P, Ruffmann R, Leuenberger P. Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebo-controlled clinical trials. Clinical therapeutics. 2000;22(2):209-221. 11. Falluel-Morel A, Lin L, Sokolowski K, McCandlish E, Buckley B, DiCicco-Bloom E. N-acetyl cysteine treatment reduces mercury-induced neurotoxicity in the developing rat hippocampus. J Neurosci Res. 2012;90(4):743-750. 12. Linus Pauling Institute. Zinc. 2019; https://lpi.oregonstate.edu/mic/minerals/zinc#impaired-immune-function. Accessed January 7, 2021. 13. Baum, M. K., Shor-Posner, G., Campa, A. (2000). Zinc status in human immunodeficiency virus infection. The Journal of nutrition, 130(5S Suppl), 1421S–3S. https://doi.org/10.1093/jn/130.5.1421S 14. Maares, M., Haase, H. (2016). Zinc and immunity: An essential interrelation. Archives of biochemistry and biophysics, 611, 58–65. https://doi.org/10.1016/j.abb.2016.03.022 15. Rondanelli M, Miccono A, Lamburghini S, et al. Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and Echinacea in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds-Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds. Evidence-based complementary and alternative medicine : eCAM. 2018;2018:5813095. 16. Hemilä H. Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage. JRSM open. 2017;8(5):2054270417694291. 17. Ginde AA, Sullivan AF, Mansbach JM, Camargo CA, Jr. Vitamin D insufficiency in pregnant and nonpregnant women of childbearing age in the United States. Am J Obstet Gynecol. 2010;202(5):436.e431-438. 18. Sassi F, Tamone C, D’Amelio P. Vitamin D: Nutrient, Hormone, and Immunomodulator. Nutrients. 2018;10(11). 19. Prietl B, Treiber G, Pieber TR, Amrein K. Vitamin D and immune function. Nutrients. 2013;5(7):2502-2521. 20. Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017;356:i6583. 21. Shi, Y. Y., Liu, T. J., Fu, J. H., Xu, W., Wu, L. L., Hou, A. N., Xue, X. D. (2016). Vitamin D/VDR signaling attenuates lipopolysaccharide-induced acute lung injury by maintaining the integrity of the pulmonary epithelial barrier. Molecular medicine reports, 13(2), 1186–1194. https://doi.org/10.3892/mmr.2015.4685 **Disclaimer Regarding Clear CV This information is for educational purposes only. We are not making the claim that Clear CV or its ingredients can prevent or fight COVID-19. It is recommended that you do your own research and consult your physician before making any decisions on what to do for your health.

Conners Clinic Berber Clear supplies berberine combined with alpha lipoic acid to help support optimal blood sugar and insulin metabolism, cardiovascular health, and liver health. Berberine is an alkaloid compound found in the roots, rhizomes, stems, and bark of several plants commonly used in botanical and Chinese medicine, such as goldenseal, Oregon grape, barberry, and Berberis aristata. Lipoic acid is best known for its antioxidant properties and its ability to support healthy insulin metabolism and sensitivity. It is also a key cofactor for mitochondrial enzymes involved in cellular metabolism and energy (ATP) production. Ingredients: Berberine hydrochloride (from Berberis aristata) (root) Alpha Lipoic Acid Berberine Berberine is a compound found in the roots, rhizomes, stems and bark of several plants commonly used in botanical and Chinese medicine, such as goldenseal, Oregon grape, barberry, and Berberis aristata (from which its name is derived). It has become increasingly popular as people seek natural compounds that may aid in maintaining healthy blood glucose and insulin levels, without some of the adverse side-effects of pharmaceutical medications commonly used for this purpose. Berberine helps promote healthy blood glucose levels and sensitivity to insulin through multiple mechanisms.* One way berberine may aid in healthy glucose regulation is by limiting the activity of enzymes that digest carbohydrates in the small intestine, thus resulting in less glucose being absorbed into the bloodstream after meals. Alpha Lipoic Acid Alpha lipoic acid (ALA) is best known as an antioxidant. ALA is both water- and fat-soluble, meaning it exerts its antioxidant effects in different types of tissues and different compartments in the body. In addition to its antioxidant effects, ALA supports healthy insulin secretion and sensitivity, in part by facilitating the way cells take up glucose from the blood. ALA is also a key cofactor for enzymes inside the cells’ mitochondria, which is where fats, carbohydrates, and proteins are converted into energy. Thus, ALA helps support a healthy metabolism. Does Not Contain: Gluten, animal or dairy products, ingredients derived from genetically modified organisms (GMOs). Warning: If you are on insulin treatment or taking hypoglycemic medications, consult with your healthcare practitioner before using this product. Berberine Synergy *NOTE: All of the above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Berberine Synergy 

Conners Originals Clear-DIM is a powerful blend of nine synergistic ingredients designed to help support healthy hormone metabolism in both men and women. Additionally, the select ingredients in this formula have been proven clinically effective in supporting health and energy, promoting healthy cortisol levels and providing dopamine support. DIM is designed to help rid your body of "bad" estrogens. Our "New and Improved" ClearDIM now contains a powerful blend of nine synergistic ingredients designed to help support healthy hormone metabolism.  Ingredients: Ashwagandha Root Extract Ginseng Root Extract Tribulus Extract Diindolylmethane (DIM) Velvet Bean Extract Stinging Nettle Root Extract Longjack Root Extract Grape Extract Betaine Does Not Contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat or soy. Potential Benefits: support healthy cortisol levels provide dopamine support support healthy hormone metabolism (for both men and women) support sexual health improve energy Videos: Directions: Take 2 capsules twice per day or as directed by your healthcare practitioner.

Conners Clinic Originals Clear Multi Min Plus is an advanced multi-mineral formula featuring TRAACS® (The Real Amino Acid Chelate System) by Albion® Laboratories, Inc., the world leader in patented mineral amino acid chelate and organic mineral acid complex research and development. This formula contains highly absorbable minerals in balanced ratios designed to prevent competition between minerals for absorption. We chose Albion® Laboratories, Inc. mineral technology to provide the highest quality minerals for optimal absorption and utilization. Ingredients: Vitamin C Vitamin D3 Calcium Iodine Magnesium Zinc Selenium Manganese Chromium Molybdenum Potassium Malic Acid Betaine hydrochloride Lithium Vanadium Does Not Contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat or soy. Directions: Take 4 capsules per day or as directed by your healthcare practitioner. NOTE: All of the above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. 

NEW ADDITION to this formula - we have added  Tinospora cordifolia - a POWERFUL, natural anti-histamine Conners Clinic Originals Clear Hist is a synergistic blend of nutrients that provides support to help balance the body’s immune response.* It features Tinofend®, a patented and clinically researched extract derived from the plant Tinospora cordifolia, which has been shown to help regulate key immune mediators and support the normal activity of macrophages. Tinofend® supports the immune response by promoting a balance of phagocytic white blood cells and eosinophils.* Clear Hist also contains quercetin, nettle leaf, and vitamin C, which have been historically used to support immune health and function.* Additionally, bicarbonate salts are included for their role in maintaining normal histamine metabolism. Ingredients Vitamin C Tinofend Quercetin  Stinging Nettle Bi-carbonate salts Potassium Sodium NEW FORMULA also contains Tinofend®, a patented and clinically researched extract derived from the plant Tinospora cordifolia, which has been shown to regulate key immune mediators and support the activity of white blood cells. Tinofend® supports the immune response by promoting a balance of immune cells, including eosinophils, which are a type of white blood cells that respond to allergens. Does Not Contain: Gluten, yeast, artificial colors or flavors Potential Benefits supports immune balance in hypersensitive individuals supports lowering histamine levels in cancer patients supports sinus and respiratory health promotes normal viscosity of mucus clears nasal passages Discussion Quercetin has strong antioxidant activity and has been shown to support immune health by mediating the release of inflammatory compounds including leukotrienes and prostaglandins. Quercetin is known for its ability to stabilize mast cells, diminishing the release of histamine, the compound known to cause hypersensitivity reactions during seasonal changes. Stinging nettles leaf is a plant that has been shown to balance immune response, specifically in the airways and nasal passages. Studies have shown that the extract of stinging nettles leaf balances a variety of inflammatory activities that affect respiratory health. Vitamin C cannot be synthesized by humans and is therefore an essential nutrient that must be consumed in the diet. Among its numerous health-promoting properties, vitamin C is an essential vitamin that supports the immune system and is also a potent antioxidant. When the body is under a significant amount of stress, vitamin C is excreted rapidly. Vitamin C has many immune boosting properties, but is distinctively beneficial for individuals with seasonal discomfort because of its ability to deactivate histamine. Directions Recommended Use: Take 4 capsules per day or as directed by your health-care practitioner. (Divided dosing recommended.)  NOTE: All of the above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. 

When you’re choosing to decrease the levels of histamine in your diet, it’s just that: decreasing. It is simply impossible (and actually unnecessary) to try to eliminate histamines. They’re everywhere. However what you can do, and should focus on, is reducing your intake of high histamine foods along with combining foods that are low in histamine with other foods can help break down and clear histamine from the body. Use this list to help lower your histamine load. Using products like our Histamine Scavenger can greatly reduce one's symptoms of excess histamine. This is one of our BEST selling products with the number of people RE-purchasing at the highest - meaning...it WORKS! On SALE this month - $3.00 off per bottle!!!! Ingredients: Larch Tree Fiber Pine Bark Extract Aloe Vera Leaf Quercetin Bromelain Nettle Leaf Marshmallow Root Bitter Orange Licorice Sugar free, salt free, starch free, preservative free, no artificial colors or flavors or additives, wheat free, soy free, yeast free, no milk derivatives Potential Benefits: Supports normal histamine levels Reduce inflammatory responses to non-allergen exposures Can help the body repair leaky gut, or prevent its onset Supports ABP1 & HNMT gene pathways Description: Histamine is a versatile, yet unique, compound that naturally interacts with several physiological pathways. Typically, bodily injury and antigen exposure promotes the release of histamine. A white blood cell variation known as a basophil and similarly constructed mast cells, found in connective tissue, are the main producers of histamine. Despite various origins and locations, histamine compounds found outside of the CNS contribute to a universal goal: initiating an inflammatory response. Histamine, as a result of corresponding neural receptors, has the potential for profound effects on the hypothalamus and other neurotransmitters: specifically effecting appetite and sleep patterns. Therefore, increased histamine can disrupt usual compound levels in the CNS.  Secreted histamine also promotes vasodilation, blood plasma release from adjacent blood vessels, and stimulates gastric acid production. Vasodilation allows for greater capillary permeability; therefore, white blood cells are capable of contacting pathogens found in interstitial fluid, also potentially effecting intestinal permeability.  Excessive histamine can be correlated to genetic mutations, leaky gut, allergies, and an individual’s diet. Studies have suggested gliadin, a protein found in wheat, to be involved with mast cell function and secretion of histamine; similarly, gliadin also stimulates the release of Zonulin. Under further observation, Zonulin has been found, during an ex vivo study, to increase intestinal permeability, serving as another contributor to a leaky gut.  Genetic mutations found in the ABP1 and HNMT genes are potential indicators for elevated histamine. Furthermore, increased histamine levels can result in heart palpitations, low blood pressure, hypertension, fatigue, anxiety, joint pain, irritable bowel syndrome, stomach ulcers, adrenal gland fatigue, and altered sleep patterns. Histamine Scavenger contains the essential ingredients believed to promote the reduction of harmful histamine accumulation. Histamine Scavenger is designed to reduce histamine (an inflammatory chemical) in the tissues. Genetic supplementation is complex and requires a deep understanding of the entire genetic picture.  Our Genetics Membership includes the kit, a full workup, review, report, summary, Dr. Conners’ personalized recommendations - and MORE.  Click HERE for details. Your browser does not support the video tag.

Conners Clinic Originals Estro Clear (formerly Aromat8-PN™ & FlashArrest) delivers a unique, proprietary blend of 8-prenylnaringenin (8-PN) from hops and plant-lignan extract at clinically relevant levels. Research suggests lignans and 8-PN can support the body’s natural process of healthy aromatase activity and exert phytoestrogen (e.g., enterolactone) and antioxidant activity. This all-natural formula may support cardiovascular, bone, breast, and prostate health and help relieve normal menopausal discomforts. Ingredients: Norway spruce lignan extract 8-prenylnaringenin (from hops extract) Does Not Contain: Wheat, gluten, corn, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives. NOTE: All of the above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. 

Are you navigating the challenges of an autoimmune condition, where typical immune-boosting solutions may do more harm than good? AI - Anti-Inflammatory + Autoimmune Formula is here to help. Specially designed to support your immune system without overstimulation, this powerful blend of scientifically-backed ingredients provides targeted relief and holistic care. Why Choose AI Formula? Anti-Inflammatory Powerhouse: Featuring Curcumin C3 Complex®, trans-Resveratrol, and Green Tea Extract (EGCG), this formula delivers potent antioxidant support to reduce inflammation and protect your cells. Immune Modulation, Not Stimulation: Crafted to support a balanced TH-2 immune system, ingredients like Grapeseed Extract and N-Acetyl L-Cysteine (NAC) work to harmonize immune responses, avoiding overstimulation that can worsen autoimmune symptoms. Advanced Biofilm and Detox Support: Our Proprietary Enzyme Blend disrupts biofilms and offers systemic enzymatic benefits, paired with the cleansing power of Terramin clay, one of nature’s most effective detoxifiers. Brain and Oxidative Stress Support: The unique nutrient profile has been studied for its benefits in brain health, helping to calm microglial activation and combat oxidative stress. Boosted Glutathione Levels: With NAC at its core, this formula supports tissue levels of glutathione, the body’s master antioxidant, to enhance natural defense systems. Perfect for Autoimmune Support Unlike traditional immune-boosting supplements that can inadvertently exacerbate autoimmune conditions, AI Formula is specifically crafted to protect your body without overburdening your immune system. It’s your ally in reducing inflammation, supporting brain health, and optimizing your body’s natural defenses—safely and effectively. Take Control of Your Health Experience the difference a thoughtful, targeted approach can make. With AI - Anti-Inflammatory + Autoimmune Formula, you don’t have to compromise on your health. Support your immune system while addressing inflammation and oxidative stress the smart way. Order Now and Take the First Step Toward Relief! NOTE: All of the above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.  Free Download - The 7 Phases of Detox References 1. Shahidi F, de Camargo AC. Tocopherols and Tocotrienols in Common and Emerging Dietary Sources: Occurrence, Applications, and Health Benefits. Int J Mol Sci. 2016;17(10):1745. Published 2016 Oct 20. doi:10.3390/ijms17101745 2. Zainal Z, Rahim AA, Radhakrishnan AK, Chang SK, Khaza'ai H. Investigation of the curative effects of palm vitamin E tocotrienols on autoimmune arthritis disease in vivo. Sci Rep. 2019;9(1):16793. Published 2019 Nov 14. doi:10.1038/s41598-019-53424-7 3. Gomes BAQ, Silva JPB, Romeiro CFR, et al. Neuroprotective Mechanisms of Resveratrol in Alzheimer's Disease: Role of SIRT1. Oxid Med Cell Longev. 2018;2018:8152373. Published 2018 Oct 30. doi:10.1155/2018/8152373 4. Malaguarnera L. Influence of Resveratrol on the Immune Response. Nutrients. 2019;11(5):946. Published 2019 Apr 26. doi:10.3390/nu11050946 5. Hewlings SJ, Kalman DS. Curcumin: A Review of Its' Effects on Human Health. Foods. 2017;6(10):92. Published 2017 Oct 22. doi:10.3390/- foods6100092 6. Al-Mousawi, A.H., Al-kaabi, S.J., Albaghdadi, A.J.H. et al. Effect of Black Grape Seed Extract (Vitis vinifera) on Biofilm Formation of Methicillin-Resis- tant Staphylococcus aureus and Staphylococcus haemolyticus. Curr Microbiol (2019) doi:10.1007/s00284-019-01827-0 7. Horibe S, Tanahashi T, Kawauchi S, Mizuno S, Rikitake Y. Preventative Effects of Sodium Alginate on Indomethacin-induced Small-intestinal Injury in Mice. Int J Med Sci. 2016;13(9):653–663. Published 2016 Aug 1. doi:10.7150/ijms.16232 8. Mackie AR, Macierzanka A, Aarak K, et al. Sodium alginate decreases the permeability of intestinal mucus. Food Hydrocoll. 2016;52:749–755. doi:10.1016/j.foodhyd.2015.08.004 9. Bavarsad Shahripour R, Harrigan MR, Alexandrov AV. N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities. Brain Behav. 2014;4(2):108–122. doi:10.1002/brb3.208 10. Razak MA, Begum PS, Viswanath B, Rajagopal S. Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Oxid Med Cell Longev. 2017;2017:1716701. doi:10.1155/2017/1716701 11. El-Hafidi M, Franco M, Ramírez AR, et al. Glycine Increases Insulin Sensitivity and Glutathione Biosynthesis and Protects against Oxidative Stress in a Model of Sucrose-Induced Insulin Resistance. Oxid Med Cell Longev. 2018;2018:2101562. Published 2018 Feb 21. doi:10.1155/2018/2101562 12. Boyer JL. Bile formation and secretion. Compr Physiol. 2013;3(3):1035–1078. doi:10.1002/cphy.c120027 13. Salem, B et al Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits. Plant Foods Hum Nutr. 2015 Dec;70(4):441-53. doi: 10.1007/s11130-015-0503-8 14. Kirchhoff, R. et al. Increase in choleresis by means of artichoke extract. Results of a randomized placebo-controlled double-blind study. Phytomed- icine 1994; 1: 107. 15. Held C. Artischoke bei Gallenwegsdyskinesien: Workshop “Neue Aspekte zur Therapie mit Chloretika.” Kluvensiek. 1991; 2:9. Cited in Kraft K. Artichoke leaf extract—Recent findings reflecting effects on lipid metabolism, liver and gastrointestinal tracts. Phytomedicine. 1997; 4(4):369-378 16. Rondanelli M. et al Health-promoting properties of artichoke in preventing cardiovascular disease by its lipidic and glycemic-reducing action. Monaldi Arch Chest Dis. 2013 Mar;80(1):17-26. 17. El-Boshy M1et al Studies on the protective effect of the artichoke (Cynara scolymus) leaf extract against cadmium toxicity-induced oxidative stress, hepatorenal damage, and immunosuppressive and hematological disorders in rats. Environ Sci Pollut Res Int. 2017 May;24(13):12372-12383.

Ingredients Quercitin Pomegranite Astaxanthin Soy free, yeast free, dairy free, sugar free, gluten free, no artificial colors or flavors, preservative free. Potential Benefits Supports PON1 gene pathways Assists the liver in its ability to remove toxins from the body Description Phase 2 - PON1 Assist is a combo product created to help support people with defects in the PON1 detoxification genes. These genes are responsible for assisting your body to get rid of large chemicals such as pesticides, insecticides, vaccinations, some medications, as well as free radicals. Mutations of the PON1 gene inhibit enzyme efficiency and are believed to create an increased risk for athero- sclerosis and other coronary implications. Paraoxonase 1, also known as PON1, is a critical enzyme located on high density lipoproteins and is responsible for hydrolyzing organo-phosphates and insecticides; therefore, the PON1 enzyme directly regulates the ability to secrete these chemicals following an environmental exposure. Organophosphates, the active ingredient found in herbicides, is known to disrupt the digestive tract and act as a neurotoxin. Symptoms of toxic levels of organophosphates include, but are not limited to, headaches, diarrhea, restlessness, convulsions, labored breathing, weakness, frequent urination, and nausea. Due to its location, the PON1 enzyme protects HDL’s against peroxidation that is implemented through contact with low density lipoproteins The ability to support the PON1 enzyme, through the supplementation of natural cofactors, has been revolutionized with PON1 Assist. Individuals with the PON1 variant should be advised to supplement with PON1 Assist for long term health support. Also consider using “Addex” Homeopathic formula if there has been exposure to insecticides and pesticides. NOTE: All of the above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.    Genetic supplementation is complex and requires a deep understanding of the entire genetic picture.  Our Genetics Membership includes the kit, a full workup, review, report, summary, Dr. Conners’ personalized recommendations - and MORE.  Click HERE for details.   Free Download - The 7 Phases of Detox Videos Pon1

SBI Protect is the only purified, dairy-free source of immunoglobulin G (IgG) available as a dietary supplement. Pure IgG helps to maintain a healthy intestinal immune system by binding a broad ranges of microbes and toxins within the gut lumen. Clear SBI Protect provides concentrated immunoglobulins to enhance mucosal immunity, help maintain microbial balance, support GI barrier health and integrity and also helps maintain normal inflammatory balance. Ingredients Serum-Derived Bovine (Immunoglobulin Concentrate) Immunoglobulin G (IgG) Does Not Contain Gluten, corn, yeast, artificial colors or flavors. Potential Benefits/Discussion The discovery that the gut barrier plays a key role in immune health fueled the search to strengthen it. In that search, researchers found that the binding capabilities of immunoglobulins have a positive effect on gut barrier function. Immunoglobulins bind microbes and toxins in the GI tract and eliminate them prior to immune system activation. As these unwanted triggers are removed, it resets healthy immune tolerance and builds a stronger barrier to the external environment. SBI and GI Health - SBI has been shown to bind microbes and toxins, further enhancing microbiome balance and facilitating gut barrier strength. Broad-spectrum binding capabilities demonstrate the positive influence of non-allergenic forms of immunoglobulins. As seen in several studies, SBI has the potential to bind many types of microbes and toxins. This binding and elimination decreases microbe and toxin encounters by the immune system and resets immune tolerance. SBI and Immune Health - In studies evaluating the effect of SBI on immune function, subjects showed positive outcomes in several areas, including inflammatory balance, gut barrier function and immune cell counts. In an open-label human clinical study, GI-challenged patients were given 2.5 mg SBI twice daily. They had increased CD4+ counts in the duodenum after eight weeks, indicating a regenerative effect on the tissue and immune function in the intestines. NOTE: All of the above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.  Directions Take 1 scoop (2.5 grams) in 4 ounces of water or the beverage of your choice 2 times daily or as recommended by your health care professional. Free Download - The 7 Phases of Detox

Conners Clinic Originals Clear Hist Jr. is a great-tasting, chewable tablet that includes a targeted blend of flavonoids, antioxidants, proteolytic enzymes and botanicals designed to provide comprehensive support for children with seasonal challenges caused by common environmental allergens. Clear Hist Jr. includes quercetin, a powerful flavonoid to support healthy histamine levels. It supplies bromelain to enhance the absorption of quercetin and to support mucosal tissue health and stinging nettles leaf to balance hyper-immune response. N-acetyl cysteine clears the airways by promoting normal viscosity of mucus. This unique nutritional combination safely promotes healthy nasal and sinus passages for children with elevated histamine and respiratory irritation. Ingredients Vitamin C Quercetin Dihydrate Stinging Nettle Bromelain N-Acetyl-L-Cysteine Does Not Contain: Gluten, yeast, artificial colors or flavors. Potential Benefits supports immune balance in hypersensitive individuals supports sinus and respiratory health promotes normal viscosity of mucus clears nasal passages Discussion Quercetin is a biologically active flavonoid antioxidant that is widely distributed in plants, oak trees, onions and tea leaves. Quercetin has strong antioxidant activity and has also been shown to support immune health by mediating the release of inflammatory compounds, including leukotrienes and prostaglandins. Quercetin is known for its ability to stabilize mast cells, which diminishes the release of histamine, the compound known to cause hypersensitivity reactions during seasonal changes. Stinging Nettles Leaf - Urtica dioica, commonly known as stinging nettles, is a plant that has been shown to balance immune response, specifically in the airways and nasal passages. Studies have shown that the extract of stinging nettles leaf balances several of inflammatory activities that affect respiratory health. In addition to controlling mast-cell degranulation, stinging nettles leaf controls prostaglandin formation and histamine action, thus contributing to a balanced inflammatory response. Bromelain is a plant enzyme naturally found on the stem and fruit of the pineapple plant. Bromelain is a proteolytic enzyme that aids in in the breakdown of large protein complexes, including antigenic compounds. Bromelain has been shown to enhance the absorption of quercetin and to reduce circulating allergenic protein complexes associated with hyper-immune sensitivity and seasonal discomfort. N-Acetyl Cysteine (NAC) is an amino acid precursor to one of the most important antioxidants in the body: glutathione. Both glutathione and NAC help reduce the viscosity of the mucus allowing for clearing of the airways and improved respiratory health. Vitamin C - Because vitamin C cannot be synthesized by the human body, it is an essential nutrient that must be consumed in the diet. Among its numerous health-promoting properties, vitamin C supports the immune system and is also a potent antioxidant. When the body is under a significant amount of stress, vitamin C is excreted rapidly. Vitamin C has many immune boosting properties, but is distinctively beneficial for individuals with seasonal discomfort because of its ability to deactivate histamine. Directions 1 tablet as needed or as recommended by your health care professional. D-Hist Jr  

NEW: Now in NEW packaging Conners Clinic Originals Hista Clear is a patented enzyme formula containing diamine oxidase (DAO) - the main enzyme responsible for the degradation of ingested histamine.  This enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract.   Our bodies are complex, and there is usually more at play than we think. What most don’t take into consideration when addressing histamine-related health issues is genetics. Whether you’re on a low histamine diet due to histamine intolerance, or simply trying to reduce high histamine foods for general health, you will benefit from understanding how your genes are related. Learn more about histamine and genetics here! Our body has two distinct methods of clearing things that could bring it harm: our immune system kills living toxins (bacteria, virus, parasites…) and our detoxification pathways clear non-living toxins (chemicals, heavy metals, drugs…). We have one other system that sits somewhere in the middle between the immune and the detoxification systems that helps with both: the mast cells. Read more about Histamine’s Double-edge Sword in the Formation and Progression of Cancer.   Clinical Applications Supports Healthy Degradation of Food-Derived Histamine* Enhances the Presence of Diamine Oxidase in the Digestive Tract* Description: Hista Clear provides a concentrated source of diamine oxidase (DAO)—the main enzyme responsible for the degradation of ingested histamine. This formula delivers the clinically researched dose of DAO in an easy-to-swallow, gastro-resistant mini-tablet, which is essential for releasing DAO in the small intestine, where it breaks down food-derived histamine. HistDAO does not manage or address antibody-related or IgE-related food allergies.* Discussion: Histamine is a bioactive or “vasoactive” amine produced in the body in response to an injury or foreign substance. It has an array of physiological effects, including increasing blood supply to specific sites in the body. In addition, histamine is involved in the immune response, regulation of gastric acid, permeability of blood vessels, contraction of muscles, and the normal response to inflammation.[1] The highest concentrations of histamine in the body are found in the gastrointestinal tract, lungs, and skin, with lesser amounts in the brain and heart.* Histamine is not only produced in the body but is also present in many fermented foods, such as sauerkraut, sausage, cheese, yogurt, and alcoholic beverages. Tuna, olives, spinach, eggplant, avocados, tomatoes, cherries, and citrus fruits are other histamine-containing foods. Despite their absence of histamine, some foods, such as berries, tea, and a variety of spices, stimulate the endogenous production of the amine due to their benzoate content. In addition, microbial fermentation can convert the histidine in high-protein foods to histamine so that the histamine content of food can increase over time.*[1] Endogenous and exogenous histamine must be broken down in order to maintain homeostasis and histamine balance. The enzyme diamine oxidase (DAO) degrades histamine by converting it from 2-(4-imidazolyl)- ethylamine to the inactive metabolite imidazole acetaldehyde.[2] The active ingredient in HistaClear is porcine-derived diamine oxidase, and research suggests that DAO derived from porcine kidney appears to have identical action to DAO derived from porcine intestine.[3] In humans and other mammals, DAO is found in high concentrations in the gastrointestinal mucosa. Animal studies suggest that circulating DAO may be a marker for mucosal integrity and maturity.[4] Certain drugs may affect histamine balance in the body by promoting histamine release or inhibiting DAO.*[2] Histamine tolerance may not be the same for everyone. Results of a double-blind, placebo-controlled crossover study suggest that tolerance to histamine can vary from individual to individual.[5] Total body histamine load must be considered when evaluating histamine tolerance, and a balance between histamine and DAO appears to be crucial to maintaining skin, rhinoconjunctival, and gastrointestinal health.[2,6] Genetic and environmental factors may interact to influence DAO expression. Ongoing research addresses the role that genetic variations may play in individual differences in DAO metabolism, and serum activity was significantly associated with seven single nucleotide variations within the DAO gene.[7,8] Histamine tolerance may be reflected in detailed questionnaires, food intake logs, trial with low-histamine diet, and measurement of DAO and histamine.*[9,10] Histamine tolerance and its manifestation may vary from organ to organ as well. A study of 39 patients suggested that intake of DAO produced a statistically significant reduction in symptoms associated with exogenous histamine ingestion, although single symptoms were not found to be reproducible.*[11] Ultimately, diminished serum DAO levels appear to be associated with changes in histamine degradation and serum histamine levels.[10] Although the mechanism of histamine degradation is uniform throughout the body, HistaClear only addresses excess exogenous histamine found in the folds, villi, and microvilli of the small intestine. HistaClear is not absorbed and therefore does not have systemic activity. A two-capsule dose of HistaClear contains 20 mg of vitamin C and 20,000 HDU (histamine degrading units) from diamine oxidase. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc.* Read our article: Low Histamine Diet: The High Histamine Foods List Genetic supplementation is complex and requires a deep understanding of the entire genetic picture.  Our Genetics Membership includes the kit, a full workup, review, report, summary, Dr. Conners’ personalized recommendations - and MORE.  Click HERE for details. Video: Directions: Take 1-2 capsules no more than 15 minutes before the consumption of histamine-rich foods, or take as directed by your healthcare practitioner. Cautions: Consult your healthcare practitioner before use, especially if you are pregnant or nursing. Keep out of reach of children. Avoid if allergic to pork or any other ingredient. HistaClear is NOT EFFECTIVE for symptoms of immune- related food allergies, such as peanuts, shellfish, etc. Your browser does not support the video tag.

Now changed to 90 Capsules per bottle with NEW formulation Turmero Clear is a full-spectrum turmeric product that contains an exclusive blend of bioactive nutrients. It is a natural turmeric matrix standardized to contain curcuminoids, turmeric oils and turmerin protein, along with many other active turmeric compounds that deliver comprehensive support. Turmero Clear offers a well-rounded blend of turmeric phytonutrients that help support normal inflammatory balance and strengthen immune reserves. The Complete Turmeric Matrix (CTM) formula provides comprehensive benefits and supports healthy breathing, cognitive function, gut and immune function. The molecular structure of CTM contributes to its bio-efficacy and maximizes its pleiotropic effects, making it an essential support to balance various biochemical pathways in our body. The Complete Turmeric Matrix is unique to Ortho Molecular Products where bio-efficacy is maintained as the ultimate focus in driving patient outcomes. NOTE: All of the above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.