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Vitamin D Supreme provides a clinically useful dose of vitamin D3 along with vitamin K as both K1 and the MK-7 form of K2. This formula contains higher therapeutic doses than Vitamin D Synergy for situations where more aggressive repletion is required. Vitamins D and K are essential for optimal bone and arterial health and for maintaining the immune system in proper balance. The amount of vitamin D and K in this formula may be beneficial for those who do not get adequate sun exposure and/or dietary sources of these vitamins. Vitamins D & K work as a team. Thus, increasing doses of vitamin D will increase the need for vitamin K. Made with non-GMO ingredients.

Vitamin D Synergy provides a clinically useful dose of vitamin D3 and vitamin K in the form of K1. This formula can be replaced with Vitamin D Supreme when more aggressive therapeutic levels of vitamin D and K are required clinically. Vitamins D and K are essential for optimal bone and arterial health and for maintaining the immune system in proper balance.Made with non-GMO ingredients. Research is pointing to more and more people suffering the consequences of vitamin D deficiency including susceptibility to serious illnesses like MS (Multiple Sclerosis). Vitamin D Synergy contains 2,000 IU of vitamin D3 as Cholecalciferol and 200 mcg of vitamin K as Phytonadione (included to prevent calcification of the arteries). Why is vitamin D deficiency on the rise? Many people are avoiding sun exposure due to fear of ozone layer problems, or because of skin cancer or concern of skin wrinkling. Twenty minutes of sun exposure daily to 6% exposed skin is necessary for maintaining our body’s own production of vitamin D. Some drugs bind fats, including fat soluble Vitamin D and contribute to low vitamin D levels. These drugs include Cholestyramine, a bile acid sequestering medication, and laxatives. Intake of Olestra and soluble fiber can also potentially reduce vitamin D absorption from food. Statin drugs can cause cholesterol levels to fall lower than ideal which may contribute to vitamin D deficiency. Patients with fat malabsorption, problems with bile production or production of lipase for digesting fats are also susceptible to low vitamin D levels. For these individuals consider LV-GB Complex™ (liver-gallbladder support formula) and/or Clear Digest (digestive support formula containing Lipase enzyme). Patients with dark skin pigmentation or a dark tan may require up to four times longer sun exposure to absorb the same amount of UVB as light or untanned skin, because melanin blocks UVB. African descent individuals have a much higher incidence of vitamin D deficiency, especially in northern states. Obese individuals can have 50% lower plasma levels of vit D than normal weight people, for the same supplementation levels or sun exposure. Women with low hormone levels are more susceptible to vitamin D deficiency. Estrogen or progesterone deficiency (amenorrhea, surgical or age-onset menopause) impairs the formation of the active form of vit D. Aging skin has a reduced capacity of vitamin D synthesis. By age 75, vitamin D levels can be 25% lower than levels in younger individuals.

We suggest you try our NEW, and I think BEST Vitamin D3 - ADK Complete - with all the fat soluble vitamins in their BEST form: See HERE  Ingredients: Vitamin D3 (2,000 IU) Vitamin A Vitamin K2 Tocotrienols   Description: Vitamin D3 Complete is formulated to respect the crucial importance of balancing vitamin D with vitamin A.* It also contains the other oil-soluble vitamins, K2 (menaquinone-7) and DeltaGOLD® tocotrienols (part of the vitamin E family). Vitamin D3 Complete is formulated for safe, long-term daily supplementation for most individuals.*Vitamin D3 Complete is in a natural base of medium chain triglycerides, and is encapsulated in state-of-the-art fish gelatin capsules. Suggested Use: As a dietary supplement, 1 capsule one or two times daily, or as directed by a healthcare practitioner.

Buy our ADK Complete instead HERE NOTE: If this product is "sold out", it is on backorder. Use this product instead:  *This item may take extra time to ship* Ingredients: Vitamin D3 (5,000 IU) Vitamin A Vitamin K2 Tocotrienols Description: Vitamin D3 Complete 5000 is formulated to respect the crucial importance of balancing vitamin D with vitamin A, especially for those who know they require extra vitamin D.* It also contains the other oil- soluble vitamins, K2 (menaquinone-7) and DeltaGOLD® tocotrienols (part of the vitamin E family).* The formulation is based on the understanding that repletion and maintenance of vitamin D levels is best accomplished with modest, regular doses of vitamin D, balanced by vitamin A, and this may better support vitamin D’s interaction with the many kinds of tissues in the human body that have vitamin D receptors.* Vitamin D3 Complete 5000 is in a natural base of sustainably sourced palm oil, and is encapsulated in state-of-the-art fish gelatin capsules. Key Features Pure, oil-soluble Vitamin D in high potency, offset with pre-formed Vitamin A* Further optimized with vitamin K2 in the potent Menaquinone-7 form, and Tocotrienols* In a base of sustainably sourced palm oil, in OceanCapsTM fish-gelatin softgel Vitamins do not work in isolation, and nowhere is this more clearly demonstrated than in the interactions among the oil- soluble vitamins. Their multiple roles in human metabolism are intertwined and interdependent in a complex system of dynamic synergism. For example, excessive vitamin A intake may increase bone fracture risk in older people, but studies show that when vitamin A is taken with vitamin D, together they help prevent bone loss, a clear demonstration that these oil-soluble vitamins work best together.* Excessive vitamin A with low or normal vitamin D can look like vitamin D deficiency. Excessive vitamin D with low or normal vitamin A can look like vitamin A deficiency. And the blood levels of the functionally deficient nutrient can remain within normal ranges. By supplementing vitamin D with vitamin A, both an unbalanced excess and an artificial deficiency of either one is avoided. In fact, taking them together may increase the effectiveness of lower doses, as well as reduce the risk of higher doses.* Vitamin A is also an important nutrient. Up to 50% of individuals do not efficiently convert beta-carotene to vitamin A, and may be at risk for vitamin A deficiency. Few of us eat vitamin A-rich foods, such as liver or kidney, on a regular basis. Vitamin A supports many body functions, including mucosal immunity and vision health.* The Council for Responsible Nutrition considers 10,000 IU of preformed vitamin A per day to be safe for most people. Vitamin K is involved with processes that help retain minerals in the bone matrix, protect soft tissue from calcification, and support nervous system functions.* Vitamin D’s best known role, that of supporting bone health, is supported synergistically by vitamin K2. Vitamin D may both increase the demand for vitamin K and interact beneficially with K-dependent proteins. Some research suggests that some problems with too much vitamin D may actually be due to insufficient vitamin K2. Vitamin A is now thought to help spare vitamin K, further counteracting potential depletion by excess vitamin D. Many studies looking at vitamin K2 for bone and arterial functions have used menaquinone-4 (MK-4), which is a synthesized chemical compound. MK-4 has a half-life of only 1-2 hours, so very high doses are usually needed, which require medical supervision for those on pharmaceutical blood thinners. Menaquinone-7 (MK-7) is a long chain menaquinone, naturally derived from natto fermentation. It has a serum half-life of 3 days, and even doses as low as 45 μg/day have been found to be biologically active and effective, with little potential for negative interactions.* Vitamin E is the fourth oil-soluble vitamin, and may interact beneficially with the other oil-soluble vitamins.* Provided in the form of DeltaGOLD® tocotrienols from annatto bean, it has shown superior antioxidant capacity.* Preliminary clinical observations suggest that when cholecalciferol is precipitated onto a medium, such as cellulose or lactose powder, the resultant dry powder form of vitamin D may be inefficiently absorbed and/or utilized by some individuals. By providing pure oil-form vitamin D in a palm oil base, in a softgel from fish gelatin, we insure that Vitamin D3 Complete 5000 avoids all such absorption concerns. *This statement has not been evaluated by the U.S. Food and Drug administration. The product is not intended to diagnose, treat, cure, or prevent any disease.