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CLINICAL APPLICATONS Convenient, Multi-faceted Bone Building Protocol Increases Skeletal Strength Promotes Healthy Bone Density Improves Bone Remodeling Provides a Comprehensive Blend of Foundational Micronutrients OVERVIEW Bone mineral density is a major determinant of bone mass and is the most commonly measured quality of bone. A number of factors contribute to bone mineral density including lifestyle factors (regular physical activity, not smoking, minimizing stress levels) and maintaining hormonal balance. Consuming a healthy diet and ensuring optimal levels of bone-building vitamins and minerals are a key therapeutic consideration for preserving bone strength. Pro Bono is a targeted bone building protocol specifically designed to increase skeletal strength and help maintain healthy bone density. It provides therapeutic doses of clinically-proven, bone-stimulating nutrients in convenient, easy-to-take packets to enhance bone formation. The foundation of Pro Bono is 1,000 mg of strontium, one of the most well-researched, bone-supporting minerals proven to strengthen the bone matrix and support skeletal density. Each serving provides the most bioavailable sources of strontium, calcium, magnesium, vitamin D3, vitamin K2, boron and other trace minerals to support bone health and maintenance. In addition, Pro Bono includes a full complement of micronutrients, making an additional multivitamin unnecessary. Suggested Use: 2 packets per day, one AM packet in the morning and one PM packet in the evening or as recommended by your health care professional Maintenance: 1 packet per day alternating one AM packet on odd days and one PM packet on even days or as recommended by your health care professional INGREDIENT BENEFITS Strontium Strontium is a mineral that is similar to the physical and chemical properties of calcium. Research has shown strontium to provide all natural bone support through its ability to increase the formation of osteoblasts while decreasing the formation of osteoclasts. Calcium Nearly 99% of the calcium within the adult skeletal system exists as a complex paired with phosphorus, called hydroxyapatite. It is commonly advised that individuals past early adolescence consume 1,000 to 1,500 mg/ day from dietary or supplement sources to support bone formation. Pro Bono is formulated with calcium citrate-malate, as well as calcium hydroxyapatite, to improve absorption and support optimal bone health. Magnesium Magnesium plays a major role in bone formation as approximately 50% of magnesium found in the body is found in the bone. Magnesium plays numerous roles in bone health including increasing calcium absorption, acting as a cofactor for alkaline phosphatase activation, as well as supporting vitamin D3 conversion in the body. Magnesium deficiency is very common–many Americans fail to acquire even the estimated average requirement (EAR). Magnesium deficiency can also be exacerbated due to factors such as excess consumption of alcohol, salt, coffee, phosphoric acid in sodas, and long-term stress. Vitamin D3 (Cholecalciferol) Vitamin D is a steroid vitamin that is known for its role in supporting bone health and aiding in the absorption of calcium and phosphate from the GI tract. Vitamin K1 (Phytonedione) & Vitamin K2 (Menaquinone) Vitamin K is responsible for synthesizing osteocalcin, a protein involved in calcium transport and properly embedding calcium into bone tissue. Vitamin K has also been shown to decrease the activity of osteoclasts, which helps to maintain bone formation and strength. Vitamin K works synergistically with vitamin D3 to improve calcium absorption and helps to bind newly absorbed calcium to the bone matrix. Boron Boron supplementation reduced urinary excretion of calcium and magnesium and increased blood levels of 17 betaestradiol and testosterone in postmenopausal women in one study. Improving boron levels has been shown to support bone health.