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No Coupons allowed for any labs Please note: you MUST be a course member or full member of ours to order labs! NOW Order directly - shipped to you through our Partners at RUPA HEALTH through our Conners Clinic LAB STORE - HERE Through Rupa Health's Physician referral services, we can now recommend labs for people in nearly every state. They have a licensed professional in every state to sign-off on any/all lab orders. Also, all labs are just 7% over doctor's cost making these a HUGE savings for patient/members!!!!! See Conners Clinic's LAB STORE HERE   Lab kit orders do NOT include the fee to go over your results.  This Array is a very cost effective, easy, and non-invasive method, to measure mucosal immune reactivity to a range of exogenous and endogenous antigens. The categories of antigens include assessments for intestinal dysfunction, food immune reactivity, gut dysbiosis, infection, and possible enteric nervous system autoimmune reactivity. This mucosal immune response is the body’s first immune system reaction. If steps to bring balance back to the mucosal immune response are not taken, the immune reactivity may result in a breach of the intestinal barrier, followed by a systemic immune reaction. The inflammation of systemic autoantibodies contributes to the progression of autoimmune and neuroautoimmune reactivities. Mucosal screening with Array 14 has the following advantages: Non-invasive specimen collection Assesses the unique mucosal reactions to an array of gut-related environmental antigens Identifies an early event in immune reactivity to an array of gut-related environmental antigens Measures immune reactivity at its earliest stage for potential Celiac disease, non-celiac gluten- sensitivity, irritable bowel disease, etc. Identify gut dysbiosis Monitor effectiveness of dietary protocols and other interventions Cost effectively assess multiple antigens at once Since the mucosal immune system is a central component of host defense, as a whole, any dysregulation and inflammatory reaction in the GI tissue may result in intestinal barrier dysfunction and the entry of digested, or undigested, dietary proteins into the circulation. Dietary proteins in the circulation result in systemic immune response and the production of very high levels of IgG and IgA against dietary proteins and peptides. This breach of the intestinal barrier by dietary proteins, and other molecules, due to loss of tolerance not only can lead to IgG and IgA production in blood, but also might lead to an immune response to different target organs and the induction of autoimmune diseases.29 44 45 46 47 48 49 Environmental triggers may have the capacity to affect the tight junctions. Such triggers may include bacterial antigens, viral antigens, mold antigens, xenobiotics, dietary components, and associated tissue antigens. The antibodies can react with their specific antigens and form immune complexes, which further contribute to the entry of antigens, immune complexes, or other inflammatory molecules into the submucosa, and then into circulation. Due to structural similarity between the intestinal barrier and blood- brain barrier (BBB), these IgA + IgM antibodies, immune complexes and inflammatory signals can also affect the integrity of the BBB resulting in autoimmunity against nervous system tissues.

Please note: you MUST be a course member or full member of ours to order labs!! NOW Order directly - shipped to you through our Partners at RUPA HEALTH through our Conners Clinic LAB STORE - HERE Through Rupa Health's Physician referral services, we can now recommend labs for people in nearly every state. They have a licensed professional in every state to sign-off on any/all lab orders. Also, all labs are just 7% over doctor's cost making these a HUGE savings for patient/members!!!!! See Conners Clinic's LAB STORE HERE   This is for patients and/or Course Members ONLY. If you are interested in this test please reach out to us at (651) 739-1248. Intestinal Antigenic Permeability Screen Actomyosin IgA Occludin/Zonulin IgG Occludin/Zonulin IgA Occludin/Zonulin IgM Lipopolysaccharides (LPS) IgG Lipopolysaccharides (LPS) IgA Lipopolysaccharides (LPS) IgM Free Download - The 7 Phases of Detox

No Coupons allowed for any labs Please note: you MUST be a course member or full member of ours to order labs!! NOW Order directly - shipped to you through our Partners at RUPA HEALTH through our Conners Clinic LAB STORE - HERE Through Rupa Health's Physician referral services, we can now recommend labs for people in nearly every state. They have a licensed professional in every state to sign-off on any/all lab orders. Also, all labs are just 7% over doctor's cost making these a HUGE savings for patient/members!!!!! See Conners Clinic's LAB STORE HERE   This is for patients and/or Course Members ONLY. If you are interested in this test please reach out to us at (651) 739-1248. Free Download - The 7 Phases of Detox

Please note: you MUST be a course member or full member of ours to order labs!! This is for patients and/or Course Members ONLY. If you are interested in this test please reach out to us at (651) 739-1248.   The Cyrex Array 20 tests for problems with the blood-brain barrier. Free Download - The 7 Phases of Detox

No Coupons allowed for any labs Please note: you MUST be a course member or full member of ours to order labs!! NOW Order directly - shipped to you through our Partners at RUPA HEALTH through our Conners Clinic LAB STORE - HERE Through Rupa Health's Physician referral services, we can now recommend labs for people in nearly every state. They have a licensed professional in every state to sign-off on any/all lab orders. Also, all labs are just 7% over doctor's cost making these a HUGE savings for patient/members!!!!! See Conners Clinic's LAB STORE HERE This is for patients and/or Course Members ONLY. If you are interested in this test please reach out to us at (651) 739-1248. Free Download - The 7 Phases of Detox

Please note: you MUST be a course member or full member of ours to order labs!! NOW Order directly - shipped to you through our Partners at RUPA HEALTH through our Conners Clinic LAB STORE - HERE Through Rupa Health's Physician referral services, we can now recommend labs for people in nearly every state. They have a licensed professional in every state to sign-off on any/all lab orders. Also, all labs are just 7% over doctor's cost making these a HUGE savings for patient/members!!!!! See Conners Clinic's LAB STORE HERE   This is for patients and Course Members only. If you are interested in this test please reach out to us at (651) 739-1248. To help better understand the Cyrex Array 7x, watch this Video HERE For more information of Cyrex testing in general, watch this Video HERE

Please note: you MUST be a course member or full member of ours to order labs!! NOW you can order directly through our Partners at RUPA HEALTH through our Conners Clinic LAB STORE - HERE Through Rupa Health's Physician referral services, we can now recommend labs for people in nearly every state. They have a licensed professional in every state to sign-off on any/all lab orders. Also, all labs are just 7% over doctor's cost making these a HUGE savings for patient/members!!!!! See Conners Clinic's LAB STORE HERE The DUTCH Complete™ is the most advanced hormone test, offering an extensive profile of sex and adrenal hormones and melatonin, along with their metabolites, to identify symptoms of hormonal imbalances. Easily collected in the comfort of your own home, samples are then sent to the lab to be processed. The DUTCH Complete™ is the most accurate test providing a complete assessment of hormonal health. The kit includes: • Easy directions and filter paper collection strips • Requisition form for patient information, pertinent supplements, medications, hormone replacement and a health questionnaire • Sealable return envelope   The results include: • Analysis of 35 different hormones: estrogen, progesterone, testosterone, DHEA-S, and cortisol along with their metabolites • Daily free cortisol patterns to provide insight into adrenal insufficiency or symptoms of chronic stress • Graphical representation of results and embedded video tutorials to assist in the hormone assessment to share with your medical provider • DUTCH OATs: Oxidative stress marker – 8-Hydroxy-2-deoxyguanosine (8-OHdG), melatonin (6-OHMS), and six organic acid tests (OATs) including markers for vitamin B12 (methylmalonate), vitamin B6 (xanthurenate), kynurenate, glutathione (pyroglutamate), dopamine (homovanillate), norepinephrine/epinephrine (vanilmandelate). Analytical and Clinical Validation Precision Analytical’s testing methods go through a rigorous validation process to verify accuracy, recovery, and linearity. We pride ourselves in relentlessly pursuing the most accurate and precise techniques available for testing. See the data on the next page to support the analytical and clinical validation of this powerful new testing model. The Easiest Patient Collection Patients collect just four or five dried urine samples over a 24-hour period. Dried samples are stable for several weeks making them convenient to ship worldwide. Effective HRT Monitoring DUTCH testing was designed to be optimally effective for most forms of hormone replacement therapy. Unique methods are used for improved monitoring of oral progesterone and vaginal hormones. DUTCH vs. Saliva Testing While the free cortisol pattern in saliva has clinical value, there is a significant missing piece to surveying a patient’s HPA-Axis function with saliva testing – measuring cortisol metabolites. To properly characterize a patient’s cortisol status, free and metabolized cortisol should be measured to avoid misleading results when cortisol clearance is abnormally high or low. Likewise with sex hormones, measuring estrogen and androgen metabolites gives a fuller picture for more precise clinical diagnosis of hormonal imbalances and HRT monitoring. DUTCH vs. Serum Testing While the most universally accepted testing method (due to the availability of FDA-cleared analyzers that are reliable and inexpensive), serum testing is lacking in some areas. Adrenal hormones cannot be effectively tested in serum because free cortisol cannot be tested throughout the day. There is also a lack of extensive metabolite testing (especially for cortisol and estrogens). DUTCH vs. 24-Hour Urine Testing There are two primary drawbacks to 24-hour urine testing of hormones. First, the collection is cumbersome, and as many as 40% of those who collect, do so in error (Tanaka, 2002). Secondly, dysfunction in the diurnal pattern of cortisol cannot be ascertained from a 24-hour collection. Some providers add saliva for daily free cortisol. DUTCH eliminates the need for two tests.

Please note: you MUST be a course member or full member of ours to order labs!! NOW you can order directly through our Partners at RUPA HEALTH through our Conners Clinic LAB STORE - HERE Through Rupa Health's Physician referral services, we can now recommend labs for people in nearly every state. They have a licensed professional in every state to sign-off on any/all lab orders. Also, all labs are just 7% over doctor's cost making these a HUGE savings for patient/members!!!!! See Conners Clinic's LAB STORE HERE The DUTCH Plus is a comprehensive dried urine and saliva test that maximizes the available information from sex and adrenal hormone production and metabolism. With easy, at-home sample collection over the course of one day, providers can gain insights into the overall diurnal pattern of free cortisol and cortisone, along with the total distribution of cortisol metabolites. This test offers further insight by including organic acid testing, which evaluates potential nutritional deficiencies, oxidative stress, gut dysbiosis, melatonin levels, and neuroinflammation. With the DUTCH Plus, providers also get a closer look into adrenal function with details about a patient’s cortisol awakening response (CAR) by showing cortisol's natural rise and fall within the first hour of waking. The results include: • Analysis of 35 different hormones: estrogen, progesterone, testosterone, DHEA-S, and cortisol along with their metabolites, plus the cortisol awakening response (CAR)  • Graphical representation of results and embedded video tutorials • DUTCH OATs: 8-Hydroxy-2-deoxyguanosine (8-OHdG), melatonin (6-OHMS), and nine organic acid tests (VMA, HVA, KYNA, MMA, Xanthurenate, Pyroglutamate, Indican, b-Hydroxyisovalerate, Quinolinate) Analytical and Clinical Validation Precision Analytical’s testing methods go through a rigorous validation process to verify accuracy, recovery, and linearity. We pride ourselves in relentlessly pursuing the most accurate and precise techniques available for testing. See the data on the next page to support the analytical and clinical validation of this powerful new testing model. The Easiest Patient Collection Patients collect just four or five dried urine samples over a 24-hour period. Dried samples are stable for several weeks making them convenient to ship worldwide. Effective HRT Monitoring DUTCH testing was designed to be optimally effective for most forms of hormone replacement therapy. Unique methods are used for improved monitoring of oral progesterone and vaginal hormones. DUTCH vs. Saliva Testing While the free cortisol pattern in saliva has clinical value, there is a significant missing piece to surveying a patient’s HPA-Axis function with saliva testing – measuring cortisol metabolites. To properly characterize a patient’s cortisol status, free and metabolized cortisol should be measured to avoid misleading results when cortisol clearance is abnormally high or low. Likewise with sex hormones, measuring estrogen and androgen metabolites gives a fuller picture for more precise clinical diagnosis of hormonal imbalances and HRT monitoring. DUTCH vs. Serum Testing While the most universally accepted testing method (due to the availability of FDA-cleared analyzers that are reliable and inexpensive), serum testing is lacking in some areas. Adrenal hormones cannot be effectively tested in serum because free cortisol cannot be tested throughout the day. There is also a lack of extensive metabolite testing (especially for cortisol and estrogens). DUTCH vs. 24-Hour Urine Testing There are two primary drawbacks to 24-hour urine testing of hormones. First, the collection is cumbersome, and as many as 40% of those who collect, do so in error (Tanaka, 2002). Secondly, dysfunction in the diurnal pattern of cortisol cannot be ascertained from a 24-hour collection. Some providers add saliva for daily free cortisol. DUTCH eliminates the need for two tests.

The Fat-Soluble Vitamins Profile is a great tool to gain an overall perspective of a patient's health, nutrient processing, and dietary insufficiencies. Serum levels of the fat-soluble vitamins A, D, E, K plus beta-carotene and coenzyme Q10 are measured to evaluate total body status of these antioxidant nutrients. What are the benefits of measuring all fat-soluble vitamins together? Testing these nutrients together in one panel is important because nutrient functionality is dependent on the adequate supply of each nutrient. For bone health, taking vitamin D without adequate levels of vitamins A, E, and K may be detrimental since all are needed for proper bone calcification. Antioxidants, such as vitamin E, CoQ10, and beta-carotene, help ensure proper oxidation-reduction chain reactions. Vitamins measured include: Vitamin A specific maintenance roles have been reported for vision, bone growth, skin and mucosal integrity, spermatogenesis, as well as protection against cataracts, atherosclerosis, macular degeneration and cancer. Vitamin D, "the sunshine vitamin", is necessary for maintaining blood levels of calcium and phosphorus for healthy teeth and bones. Vitamin D also plays a vital role in immune functions and is essential for health maintenance. Vitamin E is an important free radical scavenger and protective antioxidant for membrane tissues, helping to stop damage to healthy cells. Both gamma and alpha tocopherol are reported to better assess oxidative stress and inflammation. Vitamin K1 and K2 is important in the deposition of ionic calcium needed for proper blood coagulation (K1) and bone formation(K2). Research finds vitamin K to be a potential protector against osteoporosis, atherosclerosis, and possibly cancer (K2). Beta-carotene serves as an important antioxidant in keeping cells healthy, and also serving as a pool that is converted to vitamin A when needed. Beta-carotene also helps to identify a healthy diet. Coenzyme Q10 (CoQ10) allows food energy to be converted into cellular energy. Organs with the highest need for energy, such as the heart, lungs, and liver, require high levels of CoQ10. CoQ10 also protects cells from free radicals, helps with proper mitochondrial function, and is associated with cardiovascular health. The Fat-Soluble Vitamins Profile tests for levels of: Vitamin A Vitamin D Vitamin E Vitamin K Beta-Carotene Coenzyme Q10 Assessing fat-soluble vitamin levels is essential in patients with the following conditions: Impaired immune function Reoccuring infections Neurological disease Impaired digestion and absorption Heart disease Osteopenia and Osteoporosis Chronic fatigue Increased oxidative stress Poor dietary intake Test name(s): 0036 - Fat-Soluble Vitamins Profile - Serum Method: UPLC; EIA; Chemiluminescence *Not reported in New York Test Type: Serum Test

The Organix® Comprehensive Profile is a nutritional test providing insights into organic acids and a view into the body's cellular metabolic processes. Additionally, children's reference ranges are designed to provide more accurate pediatric nutritional evaluations. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions that maximize patient responses and lead to improved patient outcomes. Organic Acids and Nutritional Testing Organic acids are metabolic intermediates that are produced in pathways of central energy production, detoxification, neurotransmitter breakdown, or intestinal microbial activity. Marked accumulation of specific organic acids detected in urine often signals a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up or drug effect. Several of the biomarkers are markers of intestinal bacterial or yeast overgrowth. The Organix® Comprehensive nutritional test profile provides vital patient information from a single urine specimen. This organic acids nutritional test is valuable for determining: Functional vitamin and mineral status Amino acid insufficiencies like carnitine and NAC Oxidative damage and antioxidant need Phase I & Phase II detoxification capacity Functional B-complex vitamin need Neurotransmitter metabolites Mitochondrial energy production Methylation sufficiency Lipoic acid and CoQ10 status Markers for bacterial and yeast overgrowth Organic Acid Testing and Clinical Solutions: Full review of the patient's biochemical status and metabolic pathway flow can help identify areas of greatest concern.  Follow-up nutritional testing can monitor the effectiveness of selected treatments. Advantages of the Organix® Comprehensive Profile Extensive Analyte List - The Organix® Comprehensive Profile is a nutritional test which contains one of the most extensive biomarker lists in the industry. Including nutritional markers such as Quinolinate, D-Arabinitol, and 8-Hydroxy-2'deoxyguanosine, the Organix® offers great value. Innovative Method - The LC/MS-MS method, which is also used to screen newborns for metabolic disorders, requires very little sample preparation and processing. This technology provides more stability, accuracy, and sensitivity in measuring organic acids at low levels for optimum test results. Single Urine Specimen - A single overnight urine collection is easy for patients, leading to increased patient compliance. The Organix® Comprehensive nutritional test is ideal for patients who may suffer from: Weight issues Sleep abnormalities Depression Chemical Sensitivities