- Vitamin C
- Barberry extract
- Rose Hips
- Pterocarpous marsupium
- Gynostemma pentaphyllum
- Lithium orotate
Soy free, yeast free, dairy free, sugar free, gluten free, no artificial colors or flavors, preservative free
- Supports the autophagy process in the body
- balances energy
- reduces overall oxidative stress
Autophagy, a term derived from the Greek meaning “eating of self,” is a process involved in the degradation of cellular debris. Specifically, autophagy utilizes double-membrane vesicles, known as autophagosomes, to facilitate the degradation of intracellular contents, via lysosomes or proteolytic action.
Moreover, autophagy serves as a critical process for maintaining overall homeostasis: this is achieved by removing misfolded proteins, damaged organelles, and intracellular pathogens or viruses. As a result, autophagy has been reported to be implicated with numerous health concerns.
Autophagy is further imperative for balancing energy sources within periods of development, and in re- sponse to nutrient deprivation; during times of starvation or caloric restriction, autophagy occurs.
Oxidative stress and cellular damage has also been reported to promote autophagy. Several genes, and the respective proteins, are involved in the regulation of autophagy; such as, the ATG and ULK genes.
During nutrient-plentiful conditions, mTOR is stimulated and inhibits autophagy: mTOR, mammalian target of rapamycin, phosphorylates the ATG13 protein, and has been reported to interact with ULK proteins, thus mediating autophagy. The balance between mTOR and autophagy has recently received attention as an essential component to maintaining homeostasis.
Similarly, the enzyme AMP-activated protein kinase, known as AMPK, has been thoroughly researched, and has been reported to be involved with autophagy; AMPK is further involved with numerous physiological events, including cellular growth and proliferation, mitochondrial function and biogenesis, and insulin resistance. Thus, AMPK has been repeatedly reported to be involved with diabetes.
Activation of AMPK increases autophagy: the phosphorylation of ULK1 appears to be one mechanism related to AMPK-in- duced autophagy. Research has also repeatedly suggested sirtuin, 50-52 and FOXO 53-55 gene expression is also involved with regulating autophagy.
Taken together, it is important to recognize autophagy serves as an energy source, and as a method of maintaining and clearing the cell. Mutations and polymorphisms of autophagy-related genes have been extensively reported to potentially effect autophagy, and have been correlated with an array of health conditions. Autophagy Assist provides cutting-edge, dietary supplementation designed to support the body’s natural ability to perform autophagy.
Autophagy Assist, as its name implies, supports the process of autophagy, the removal of misfolded proteins, damaged cell components, and intracellular pathogens and debris. This critical biological process is also important in balancing energy, oxidative stress, and overall homeostasis. This cutting-edge formulation provides nutrients that support the process of autophagy in the body.